Limit content of Taws in the blood is observed for 3 hours after oral administration of the capsules. Absorption may be about 30%. When you use Taksi in conjunction with food, the maximum content of the drug in the blood rises. With the use of Tasign in half an hour or 2 hours after meals, the bioavailability of the medication is increased by 29 or 15%, respectively. Absorption of Tacos may be disturbed in patients undergoing gastrectomy surgery or partial gastrectomy.
The binding to plasma proteins may be about 98%.
The basic ways of metabolism of Tasign are the processes of oxidation and hydrooxidation. The main ingredient in the blood serum is nilotinib.
After a single-dose dose, more than 90% of the drug is excreted throughout the week, with mostly caloric masses.
The expected half-life, calculated to determine the kinetic properties of the multiple Tasigne techniques, was 17 hours.
Exposure of the active ingredient of Tasigne in a state of equilibrium is considered dose-dependent. The equilibrium is reached most often on the eighth day. The increase in serum exposure of nilotinib between the intake of the initial dose and the onset of equilibria was twice taken once a day, or 3.8-fold when taking Tasox twice a day.