Tamsol

Tamsol is a drug that is used to treat bladder disorders that occur due to benign prostatic hyperplasia.

Indications Tamsol

The drug is indicated for the relief of symptoms of dysuria.

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Release form

Available in capsules of 0.4 mg, 10 per blister. One package contains 1 or 3 blisters.

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Pharmacodynamics

Competitively selectively synthesized with postsynaptic receptors α1 (subtypes α1A, as well as α1D), and in addition prevents an increase in the tone of the smooth muscles of the prostate gland. Due to this effect, the outflow of urine is increased, which ultimately helps to get rid of obstruction.

The drug reduces the manifestations of obstruction along with irritation, which develop due to weakening of the tone of the urethra, as well as strengthening of the tone of the muscles in the lower parts of the urethra.

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Pharmacokinetics

Tamsulosin is almost completely absorbed through the intestine, but this indicator decreases when taken with food. Taking the drug at the same time of day after meals will provide the same conditions for absorption. Bioavailability is ≈100%. The peak concentration in the blood plasma after taking a single dose is reached after about 6 hours. In case of repeated use of capsules, the concentration occurs on the 5th day, and the peak indicator will be ⅔ higher than the level of a single dose.

It binds to plasma proteins by 99%, and the volume of distribution is 0.2 l/kg.

The process of tamsulosin metabolism occurs in the liver, rather slowly, its primary phase is insignificant. The main part of the active substance remains unchanged in the plasma. The decay products are less active.

The active ingredient and its metabolites are excreted from the body with urine, 9% of which are excreted unchanged. After a single dose, the half-life is 10-13 hours.

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Dosing and administration

The medicine should be taken 1 capsule/day after meals at the same time of day. The capsule should not be chewed or broken, so as not to disrupt the prolonged release of the active component. The duration of the treatment course is determined by the doctor.

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Contraindications

Tamsol is contraindicated in the following cases:

• History of postural hypotension;
• Intolerance to any component of the drug;
• Severe liver failure.

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Side effects Tamsol

Among the manifestations of adverse reactions to the drug:

• Headaches and dizziness;
• Increased heart rate;
• Postural hypotension;
• Constipation or diarrhea;
• Runny nose;
• Vomiting with nausea;
• Itching, as well as skin rashes, hives;
• Retrograde ejaculation;
• Asthenic disorders;
• Syncopal states;
• Quincke's edema;
• Priapism.

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Overdose

Acute overdose may provoke the development of hypotension. In such a situation, treatment will consist of maintaining the cardiovascular system. To stabilize blood pressure and heart rate, the patient should take a lying position. If necessary, drugs are administered that restore the volume of circulating blood, and in addition, vasoconstrictor drugs. Kidney function is monitored. Dialysis will be ineffective, because tamsulosin has a high affinity for plasma proteins.

To prevent absorption of the substance, vomiting should be induced. If a high dose is consumed, gastric lavage and activated carbon should be administered. The patient should also be given an osmotic laxative (such as sodium sulfate).

Interactions with other drugs

The drug does not interact with substances such as enalapril and theophylline, as well as atenolol and nifedipine.

Cimetidine increases, and furosemide, on the contrary, decreases the concentration of the active component of the drug in the blood plasma. Other indicators of these drugs do not exceed the permissible limits, so there is no need to adjust the dosage.

In vitro testing showed no change in the free fraction of tamsulosin when combined with propranolol, chlormadinone, diazepam, and also trichlormethiazide, diclofenac, warfarin, and glibenclamide; the drug was also combined with simvastatin and amitriptyline without changes.

In vitro testing with liver microsomes (a drug metabolism enzyme system that is linked to cytochrome P450), tamsulosin showed no interaction with substances such as salbutamol, finasteride, as well as amitriptyline and glibenclamide.

Warfarin, as well as diclofenac, accelerate the process of eliminating tamsulosin.

Tamsulosin can increase the hypotensive properties of other drugs (alpha-blockers and anesthetics).

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Storage conditions

The medicine must be stored at a temperature of 15-30°C, in a place inaccessible to children and protected from the sun.

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Shelf life

Tamsol is permitted to be used for 3 years from the date of manufacture of the drug.

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