Tamsol

Tamsol is a medicinal product that is used in the treatment of disorders in the functioning of the bladder that occur against the background of benign prostatic hyperplasia.

Indications Tamsol

The medicine is indicated for the elimination of dysuria symptoms.

[1], [2]

Release form

Produced in the form of capsules with a volume of 0.4 mg of 10 pcs. On the blister. One package contains 1 or 3 blisters.

[3]

Pharmacodynamics

It is competitively selectively synthesized with postsynaptic receptors α1 (subtypes α1A, as well as α1D), and besides it prevents the increase in the tone of the smooth muscles of the prostate gland. Due to this influence, the outflow of urine increases, which as a result helps to get rid of obstruction.

The drug reduces the manifestations of obstruction along with irritation, which develop due to weakening of the tone of the urethra, as well as strengthening the tone of the muscles in the lower parts of the urinary canal.

[4], [5]

Pharmacokinetics

Tamsulosin is almost completely absorbed through the intestine, but in the case of admission, along with food, this indicator decreases. Drug use at the same time of day after meals will provide the same conditions for absorption. Bioavailability is ≈100%. The peak concentration in the blood plasma after the use of a single dose reaches about 6 hours. In the case of repeated capsules, the concentration falls on the 5th day, and the peak value will be ⅔ higher than the level of the single dose.

Plasma proteins are bound to 99%, and the volume of distribution is 0.2 l / kg.

The process of tamsulosin metabolism occurs in the liver, rather slowly, its primary phase is insignificant. The bulk of the active substance remains unchanged in the plasma. The decay products are less active.

The active ingredient and its metabolites are excreted from the body together with urine, 9% of them being unchanged. After using a single dose, the elimination half-life is 10-13 hours.

[6], [7], [8]

Dosing and administration

You need to take the medicine for 1 caps. / Day. After eating at the same time of day. The capsule does not need to be chewed or broken so as not to interfere with the prolonged release of the active ingredient. The duration of the treatment course is determined by the doctor.

[12]

Contraindications

Tamsol is contraindicated in such cases:

• Postural hypotension, available in history; 
• Intolerance to any component of the drug;
• Hepatic insufficiency, taking place in severe form.

[9]

Side effects Tamsol

Among the manifestations of adverse reactions to the drug:

• Headaches and dizziness;
• Increased heart rate;
• Postural hypotension;
• Constipation or diarrhea;
• Coryza;
• Vomiting with nausea;
• Itching, as well as rashes on the skin, hives;
• Retrograde ejaculation;
• Asthenic disorders;
• Syncopal states;
• Quincke's edema;
• Priapism.

[10], [11]

Overdose

Acute overdose can trigger the development of hypotension. In such a situation, the treatment will consist in maintaining the cardiovascular system. To stabilize blood pressure and the rhythm of the heartbeat, the patient needs to assume the lying position. If necessary, drugs are introduced that restore the volume of circulating blood, and in addition, vasoconstrictive drugs. Kidney monitoring is being performed. Dialysis will not be effective, because tamsulosin has a high affinity with plasma proteins.

To prevent absorption of the substance, it is necessary to induce vomiting. If a high dose is used, a procedure for washing the stomach and taking activated charcoal is required. Also, the patient is given an osmotic laxative (for example, sodium sulfate).

Interactions with other drugs

The drug does not interact with substances such as enalapril and theophylline, as well as atenolol and nifedipine.

Cimetidine increases, and furosemide, on the contrary, reduces the concentration in the blood plasma of the active component of the drug. Other indicators of these drugs do not exceed the allowable limits, so you do not need to adjust the dosage.

During the in vitro testing, the free tamsulosin fraction did not change when combined with propranolol, chloromadinone, diazepam, and in addition trichloromethiazide, diclofenac, warfarin and glibenclamide; without changes, the drug was also combined with simvastatin and amitriptyline.

When tested in vitro liver microsomes (an enzyme system of drug metabolism that is connected to cytochrome type P450), tamsulosin did not show interactions with substances such as salbutamol, finasteride, and amitriptyline and glibenclamide.

Warfarin, as well as diclofenac, accelerate the process of removing tamsulosin.

Tamsulosin is able to increase the hypotensive properties of other drugs (alpha-blockers and anesthetics).

[13], [14], [15]

Storage conditions

Store the medicine required in the temperature range of 15-30 ° C, in a place that is inaccessible to children and is closed from the sun. 

[16], [17]

Shelf life

Tamsol is allowed to be used for 3 years after the manufacture of the medicine.

[18], [19], [20], [21], [22]