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Tamsonik
Last reviewed: 23.04.2024
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Tamsonik is an α-blocker, which is used in the treatment of benign prostatic hyperplasia.
Indications Tamsonik
The drug is indicated for symptomatic treatment of functional disorders in BPH.
Release form
Produced in the form of capsules. One blister contains 10 capsules. One package contains 3 blister plates.
Pharmacodynamics
Selectively blocks postsynaptic adrenergic receptors (type α1A) in the smooth muscles of the prostate, the prostate area of the urethra, and besides this neck of the urethra, and also lowers the muscle tone of these organs. The ability to interfere with the activity of adrenoreceptors of the α1A type is 20 times greater than the similar effect on adrenoreceptors of the α1B type in smooth vascular musculature. In this case, there is no significant effect on systemic blood pressure. In addition, the drug reduces the strength of the manifestations of irritation with obstruction in the urinary tract in BPH, and improves the function of urine outflow. The effect of taking drugs appears after 2 weeks.
Pharmacokinetics
After oral administration, Tamsonik absorbs almost everything in the digestive tract (more than 90% of the substance). In the case of reception, along with food, bioavailability increases, as well as the peak concentration in the blood plasma, while the time to reach this peak increases (when administered on an empty stomach it occurs after 4-5 hours, and when taken with food - after 6-7 hours). The indicator of equilibrium concentration reaches by the 6th day of course use, and the peak values in this case will be 60-70% higher than Cmax after single use.
With plasma proteins (mainly α1-glycoproteins) binds to 94-99%, and the distribution volume is 0.2 l / kg of weight. Metabolism occurs in the liver with the participation of cytochrome P450, rather slowly, in the process of forming active degradation products, which retain high selectivity for α1-adrenergic receptors. In the blood plasma is in unchanged form.
The half-life is 9-13 hours in a healthy person, and the treatment time is 14-15 hours. Most of the substance is excreted through the kidneys under the guise of conjugates of the decomposition products together with H2SO4 and glucuronic acid (10% remain unchanged), and the remaining small part excreted with feces.
Dosing and administration
Contraindications
The drug is contraindicated to use with: intolerance of the components of drugs, available in the history of postural hypotension, and in addition with renal or hepatic insufficiency. Also it can not be used by children and women.
Side effects Tamsonik
Adverse reactions after taking medication:
- Organs of the cardiovascular system: in very rare cases, postural hypotension;
- Sense organs and NS: rarely headache and dizziness, as well as asthenia, very rarely - insomnia or vice versa feeling drowsy;
- Organs of the genitourinary system: rarely (8.4%), reverse ejaculation, extremely rarely - a decrease in libido;
- Other: in some cases, a runny nose, back pain, diarrhea, extremely rarely - nausea or pain in the sternum.
[1]
Overdose
Among the symptoms of overdose: a strong drop in blood pressure. In this case, the patient should lie down, after which he is administered vasoconstrictive drugs or plasma replacing solutions. To prevent absorption of the drug, you should rinse the stomach, drink activated charcoal, and then apply an osmotic laxative. Since tamsulosin hydrochloride binds to plasma proteins by 94-99%, hemodialysis will be effective.
Interactions with other drugs
In the case of combination with other adrenoblockers such as α1A, hypotensive properties may increase.
When tamsulosin is combined with cimetidine, the first cleansing factor is reduced by 26%, and the AUC is increased by 44%.
In conjunction with furosemide, the concentration of the drug in the blood plasma decreases.
Simultaneous reception with warfarin or diclofenac accelerates the process of removing tamsulosin from the body.
[4]
Storage conditions
Keep the medicine in a temperature condition of not more than 25 ° C.
Shelf life
Tamsonik is allowed to be used for 2 years from the date of manufacture of the medicine.
Attention!
To simplify the perception of information, this instruction for use of the drug "Tamsonik" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.