Tahisteen

Tahistin solution based on dihydrotachysterol refers to drugs that regulate calcium-phosphorus metabolism.

Indications of the tahisteen

Purpose Tahistin is practiced:

• hypocalcemia caused by hypoparathyroidism (spontaneous, posttraumatic or postoperative - for example, after therapy with radioactive iodine, in tumors, tuberculosis or sarcoidosis);
• hypocalcemia caused by pseudohypoparathyroidism (with Albright);
• with hereditary hypophosphatemia, accompanied by a D-resistant form of rickets;
• in osteodystrophic processes, tetany.

Release form

Tachystin is produced in the form of droplets, which are a transparent, oily liquid with a yellowish tinge.

One milliliter of the solution contains 1 mg of the active ingredient dihydrotachysterol.

The liquid is packaged in flasks of 20 ml each, equipped with a dispensing drip device.

Pharmacodynamics

The active ingredient of Tachystin is dihydrotachysterol, which is a 5-6 transanalog of vitamin D, normalizing the metabolism of calcium and phosphorus.

Tachystin improves the absorption of calcium in the intestinal cavity, increases the transport of calcium from the bone system, which leads to an increase in the concentration of calcium in the blood.

Since dihydrotachysterol has a stereochemical configuration, it does not need the presence of parathyroid hormone for activation in the kidney system.

Pharmacokinetics

The active ingredient Tahystin has a structural structure close to vitamin D ₃. After ingestion, the drug is absorbed into the small intestine and subjected to hydroxylation in the liver.

After a single intake of the standard oral volume of Tachystin, the limiting concentration in plasma is detected after seven days. The action of Tahistin lasts up to one month.

Dosing and administration

The amount of Tachystin that is required for treatment is determined on an individual basis. Basically, the dosage depends on the calcium content in the circulatory system. Concentration content in the serum is recommended in the range of 2.25-2.5 mmol / liter.

Adults are prescribed Tahystin in a daily amount of 0.5-1.5 mg daily, which corresponds to 12-36 drops.

Approximately one week after the start of treatment, the dosage of Tachystin can be revised towards the supporting amount of the drug (for example, 0.5-1.5 mg 1-3 times a week).

The maximum allowable daily dosage should correspond to 0.0417 mg per kg of body weight.

Tahystin is taken immediately before or after a meal. It is not recommended to dilute the drug in water or another liquid.

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Use of the tahisteen during pregnancy

A solution of Tachystin does not have a toxic effect on the fetus, provided that a therapeutically adequate amount of the drug is consumed.

However, excessive intake of Tachystin by pregnant patients can provoke a persistent delay in mental and physical development, supravalvular aortic stenosis and retinopathy in a newborn child.

It is not known whether the active ingredient Tahistin enters the mother's milk. Nevertheless, during the entire period of therapy, women are advised to regularly monitor the amount of calcium in the blood.

Take Tahistin without doctor's recommendation is prohibited.

Contraindications

The doctor can not appoint Tahistin:

• with excess amount of calcium in the blood;
• at a hypersensitivity of an organism of the patient to vitamin D, a peanut and other components of a medicinal solution;
• with convulsions resulting from the so-called hyperventilation tetany.

Relative contraindication is the presence of kidney stones.

Side effects of the tahisteen

During treatment with Tachystin solution, there is a risk of hypercalcemia, the signs of which are:

• loss of appetite;
• a feeling of nausea, vomiting;
• diarrhea;
• blanching of the skin;
• pain in the head;
• a feeling of palpitations;
• dry mouth.

A prolonged increase in the level of calcium in the bloodstream can lead to impaired renal function, calcification of the coronary and pulmonary tissues.

Further bone decalcification can lead to the development of osteoporosis.

Individual patients may develop an allergy to Tachystin.

Overdose

Increased calcium content in the bloodstream due to an overdose of tachystin can trigger an acute dangerous condition that persists for several weeks even if the drug is discontinued. The signs of this state are:

• diarrhea;
• vomiting and loss of appetite;
• difficulty breathing;
• muscle paralysis;
• a disorder of kidney function with the formation of stones.

There is also such a thing as chronic overdose, which develops with prolonged state of hypercalcemia. This condition leads to erythrocyturia, the appearance of protein in the urine, crystalluria, and also the formation of calcifications in the heart muscle, in the lung tissues, in the vascular walls. Excretion of calcium from the bone system can cause demineralization of bones and the development of osteoporosis.

There is no special medication for overdose symptoms. As a rule, diuretics are used for forced diuresis, and certain changes in nutrition are introduced: the food should not contain calcium. It is possible to use calcitonin, corticosteroids.

Interactions with other drugs

Do not combine tachystin with drugs containing vitamin D, since the mechanism of action of such medications is the same.

The combination of Tachysteen with other medicines containing calcium increases the risk of hypercalcemia.

The combination of thiazides also threatens the state of hypercalcemia, as well as the increased toxic effect of digitalis preparations.

Do not combine Tachystin and thyroxine.

The combination of tachystin with cardiac glycosides can lead to an increase in their toxic effect and the development of arrhythmia. Therefore, if this combination is not avoided, the patient should regularly monitor cardiac activity on the ECG, and also check the blood composition and calcium level.

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Storage conditions

Preserve Tahystin in normal temperature conditions (up to + 25 ° C), in a dark place, hard to reach for children. It is recommended to place the package in a vertical position during storage.

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Shelf life

Factory unopened packaging with Tachystin solution can last up to 3 years, and if the packaging is opened, the storage term is reduced to one and a half months.