Tahistine

Tahistin solution based on dihydrotachysterol belongs to medications that regulate calcium-phosphorus metabolism.

Indications Tahistine

The appointment of Takhistin is practiced:

• in hypocalcemia caused by hypoparathyroidism (spontaneous, post-traumatic or post-operative - for example, after therapy with radioactive iodine, in tumor processes, tuberculosis or sarcoidosis);
• with hypocalcemia caused by pseudohypoparathyroidism (Albright's syndrome);
• in hereditary hypophosphatemia accompanied by D-resistant rickets;
• in osteodystrophic processes, tetany.

Release form

Takhistin is produced in the form of drops, which are a transparent oily liquid with a yellowish tint.

One milliliter of solution contains 1 mg of the active ingredient dihydrotachysterol.

The liquid is packaged in 20 ml bottles equipped with a dosing dropper.

Pharmacodynamics

The active ingredient of Tahistin is dihydrotachysterol, which is a 5-6-trans analogue of vitamin D, which normalizes the metabolism of calcium and phosphorus.

Tahistin improves the absorption of calcium in the intestinal cavity, increases the transport of calcium from the skeletal system, which leads to an increase in the concentration of calcium in the blood.

Since dihydrotachysterol has a stereochemical configuration, it does not require the presence of parathyroid hormone for activation in the renal system.

Pharmacokinetics

The active ingredient Tahistin has a structural structure similar to vitamin D ₃. After oral administration, the drug is absorbed in the small intestine and undergoes hydroxylation in the liver.

After a single dose of a standard oral dose of Tahistin, the maximum plasma concentration is detected after seven days. The effect of Tahistin lasts up to one month.

Dosing and administration

The amount of Tahistin required for treatment is determined individually. The dosage mainly depends on the calcium content in the circulatory system. The recommended serum concentration is 2.25-2.5 mmol/liter.

Adults are usually prescribed Takhistin in a daily dose of 0.5-1.5 mg daily, which corresponds to 12-36 drops.

Approximately one week after the start of treatment, the dosage of Tahistin can be revised towards a maintenance dose of the drug (for example, 0.5-1.5 mg 1-3 times a week).

The maximum daily dose should be 0.0417 mg per kg of body weight.

Tahistin is taken immediately before or after meals. It is not recommended to dilute the medicine in water or other liquid.

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Use Tahistine during pregnancy

Tahistin solution does not have a toxic effect on the fetus, provided that a therapeutically adequate amount of the drug is consumed.

However, excessive use of Tahistin by pregnant patients may cause persistent mental and physical developmental delay, supravalvular aortic stenosis and retinopathy in the newborn child.

It is not known whether the active ingredient Tahistin passes into breast milk. However, women are advised to regularly monitor the amount of calcium in the blood during the entire period of therapy.

Taking Takhistin without a doctor's recommendation is prohibited.

Contraindications

The doctor cannot prescribe Tahistin:

• with excess calcium in the blood;
• in case of hypersensitivity of the patient's body to vitamin D, peanuts and other components of the medicinal solution;
• in convulsions that occur as a result of so-called hyperventilation tetany.

The presence of kidney stones is considered a relative contraindication.

Side effects Tahistine

During treatment with Tahistin solution, there is a risk of hypercalcemia, the signs of which are:

• loss of appetite;
• feeling of nausea, vomiting;
• diarrhea;
• paleness of the skin;
• headaches;
• sensation of heartbeat;
• dry mouth.

A prolonged increase in calcium levels in the bloodstream can lead to impaired renal function and calcification of coronary and pulmonary tissue.

Further bone decalcification may lead to the development of osteoporosis.

Some patients may develop an allergy to Tahistin.

Overdose

Increased calcium levels in the bloodstream due to an overdose of Tahistin can cause an acute dangerous condition that persists for several weeks even if the medication is discontinued. Signs of such a condition include:

• diarrhea;
• vomiting and loss of appetite;
• difficulty breathing;
• muscular paralysis;
• renal dysfunction with stone formation.

There is also such a concept as chronic overdose, which develops in a long-term state of hypercalcemia. This condition leads to erythrocyturia, the appearance of protein in the urine, crystalluria, and also to the formation of calcifications in the heart muscle, in the lung tissue, in the vascular walls. The removal of calcium from the skeletal system can cause bone demineralization and the development of osteoporosis.

There is no special medication to stop the signs of overdose. As a rule, diuretics are used for forced diuresis, and certain changes in nutrition are introduced: food should not contain calcium. Calcitonin and corticosteroids may be used.

Interactions with other drugs

Tahistin should not be combined with drugs containing vitamin D, since the mechanism of action of such medications is the same.

The combination of Tahistin with other medications containing calcium increases the risk of developing hypercalcemia.

The combination of thiazides also poses a risk of hypercalcemia and increased toxicity of digitalis preparations.

Tahistin and Thyroxine should not be combined.

The combination of Tahistin with cardiac glycosides may lead to an increase in their toxic effect and the development of arrhythmia. Therefore, if such a combination cannot be avoided, the patient should regularly monitor cardiac activity on the ECG, as well as check the blood composition and calcium levels.

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Storage conditions

Store Takhistin under normal temperature conditions (up to +25°C), in a dark place, out of reach of children. It is recommended to keep the package in a vertical position during storage.

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Shelf life

The original unopened packaging of Takhistin solution can be stored for up to 3 years, and if the packaging is opened, the storage period is reduced to one and a half months.