Uregit

Uregit tablets based on ethacrynic acid are a potent diuretic that is often prescribed for certain kidney or cardiovascular problems.

Indications Uregita

The prescription of the drug Uregit is appropriate for edema of various origins: in patients with chronic cardiac insufficiency, with liver cirrhosis, with diseases of the urinary organs.

In addition, Uregit can be used for fluid accumulation in the abdominal cavity, as well as for the treatment of lymphatic or idiopathic edema.

Uregit can be prescribed in case of decreased sensitivity to other diuretics.

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Release form

Uregit has the appearance of round, flattened, light-colored tablets with a dosing notch and the inscription UREGYT.

The cardboard pack contains two blister plates, 10 tablets in each plate.

One tablet contains 50 mg of ethacrynic acid.

Pharmacodynamics

The main ingredient of the drug Uregit is ethacrynic acid, which is a powerful fast-acting diuretic. The drug blocks active chlorides and, accordingly, sodium transport in the ascending part of the loop of Henle.

The diuretic effect of Uregit significantly exceeds the effect of some thiazide drugs. In addition, the drug Uregit has virtually no diabetogenic effect.

Pharmacokinetics

Uregit shows its effect half an hour or an hour after taking the tablets.

The peak effect is observed within two hours, with the diuretic effect lasting from six to eight hours.

The connection with whey proteins reaches 90%.

A certain amount of the active ingredient is conjugated in the liver. Up to 67% of the consumed amount of the drug is excreted from the body through the kidneys, and up to 33% through the intestines, partially - up to 20% - in unchanged form or in the form of a conjugated metabolic product.

The half-life can range from one to four hours.

Dosing and administration

The regimen for taking Uregit is developed individually, since the degree of need to increase diuresis depends on the severity of edema and the general health of the patient.

At the beginning of therapy, it is recommended to use the minimum amount of Uregit - from 25 to 50 mg (half or a whole tablet). Uregit is taken with the morning meal, or immediately after it. The initial amount of the drug can be gradually increased by 25 mg. It is best to do this once every 2-3 days.

Standard maintenance treatment is carried out using 25-200 mg of Uregit per day. In rare cases, the dose can be increased to the maximum permissible dose, which is 400 mg.

Any daily dose of the drug exceeding 50 mg should be taken in two doses – during breakfast and during dinner.

It should be taken into account that elderly patients may only need to take a minimal amount of Uregit.

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Use Uregita during pregnancy

It is prohibited for women to take Uregit at any stage of pregnancy, as well as while breastfeeding.

Uregit can provoke the development of hypovolemia, increase blood viscosity, which will generally negatively affect the quality of placental circulation.

Contraindications

The doctor will not prescribe Uregit for the following diseases and conditions:

• if you are prone to allergic reactions to any of the ingredients of Uregit;
• in case of difficulty in passing urine;
• in case of significant disturbances of water and electrolyte metabolism, as well as in case of disturbance of acid-base balance;
• in hepatic coma;
• during pregnancy and lactation.

Side effects Uregita

Treatment of Uregit is often accompanied by the following side effects:

- decrease in blood pressure due to increased diuresis;

- decreased sodium levels in the blood, cramps, thirst, difficulty swallowing, abnormal heart rhythms, nausea, feeling of fatigue, weakness;

- indigestion (acute profuse diarrhea), loss of appetite, abdominal pain, pancreatitis;

- anxiety, headaches, dizziness, numbness of the limbs;

- ringing in the ears, hearing loss.

If severe side effects occur, in some cases it may be necessary to immediately discontinue Uregit.

Less common side effects include:

• allergy, exacerbation of gout;
• hyperglycemia;
• feverish conditions, the appearance of blood in the urine, gastric bleeding, weight loss;
• liver failure;
• pancreatitis.

Overdose

Taking excessive amounts of Uregit can provoke an increase in urine output, up to and including electrolytic imbalance, dehydration, and hepatic coma. Dehydration is manifested by symptoms such as a drop in blood pressure, aggravation of facial features, and abnormal heart rhythms.

There is no antidote as such.

If overdose is suspected, the patient should be induced to vomit and the stomach should be emptied as soon as possible. Further treatment is prescribed depending on the symptoms.

In severe cases, with respiratory failure, oxygen therapy and artificial ventilation are performed.

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Interactions with other drugs

Uregit and ethyl alcohol: possible excessive decrease in blood pressure and increased diuresis.

Uregit and ACE inhibitors: a sharp drop in blood pressure is possible.

Uregit and anticoagulant drugs: possible enhancement of the anticoagulant effect.

Uregit and nonsteroidal anti-inflammatory drugs: may counteract the diuretic effect.

Uregit and antibiotics: the ototoxic properties of aminoglycoside and certain cephalosporin drugs increase.

Uregit and lithium preparations: possible increase in the toxic effect of lithium.

Uregit and corticosteroids: the risk of developing gastrointestinal bleeding increases.

Uregit and foxglove preparations: the toxic effect of digitalis increases.

Uregit and oral medications for the treatment of diabetes: the effect of the latter is reduced.

Uregit and Indomethacin: the diuretic effect is worsened.

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Storage conditions

It is necessary to store Uregit in the original packaging, at a temperature not exceeding +25°C. It is necessary to protect the medicines from direct sunlight, from dampness, and also from free access of children.

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Shelf life

The packaged drug Uregit can be stored for up to 5 years.