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A combined chondroprotector consisting of equal parts (500 mg each) of chondroitin sodium sulfate and glucosamine hydrochloride, which interact productively with each other. The first component gives joints flexibility, promotes the preservation of water in the cartilaginous tissue and deactivates the enzymes that destroy the cartilage. The second is the building substance for the formation of cartilaginous tissue. Promotes the formation of chondroblasts, i.e. Restoration of the cartilage tissue destroyed by the disease, restores the mobility of the joints, and has analgesic effect. Chondroitin accelerates chondrohystogenesis, i.e. The creation of cartilaginous tissue, begins to outstrip its destruction. Glucosamine stabilizes this process. The active substances of the preparation stimulate the synthesis of the basis of connective tissue (proteoglycans), which serves as a lubricant in the joints, due to this, the perichondrium of the bones in the joint begin to wear out less, and the tenderness of the joints passes.
The use of Arthra tablets helps to reduce the dose of NSAIDs and hormonal drugs, which are used for inflammation with severe pain.
When the drug is taken, the bioavailability of the active substances is 25% of glucosamine and 13% of chondroitin. The liver, kidneys and articular cartilage accumulate a high concentration of active elements of the tablets. About a third of the glucosamine taken remains for a long time in the tissues of bones and muscles. It is excreted mainly by the kidneys, and also by the intestines.
This is a dosage form for oral administration. To avoid contact with the oral mucosa, the tablets are released in the shell. Accept, without violating integrity, autonomously from eating, squeezed with enough drinking water.
It is addressed only to adult patients. In the absence of other recommendations, take one tablet in the morning and in the evening for three weeks, then reduce the dose to one tablet per day.
Duration of treatment is approximately 4-6 months. If necessary, you can repeat the course of taking Arthra tablets in a few months.
The duration of the course and the dosage of the drug, corresponding to the severity of the disease, is established by the attending physician.
The use of these tablets rarely causes side effects. There are single episodes of epigastric pain, stool, flatulence and dizziness during treatment with this drug. In rare cases, an allergic reaction may occur.
Usually, severe idiosyncrasies, requiring the withdrawal of treatment with this drug, were not observed. The appearance of unwanted effects should be reported to the doctor in charge.
Care should be exercised when managing permissible dangerous devices, for example, when driving a car, during treatment with this drug (dizziness caused by glucosamine).
Contraindications to the use of Artra tablets are the established hypersensitivity to their components, renal dysfunction, children and adolescence, pregnancy and the period of breastfeeding. With caution apply to patients with bronchial asthma, diabetes, bleeding or its risk of occurrence
Arthra in the interaction with NSAIDs and glucocorticosteroids, fibrinolytic drugs, as well as drugs that prevent the formation of thrombi or inhibit platelet aggregation, enhances their effectiveness.
Interacting with tetracyclines, their absorption in the intestine increases.
When combined, reduces the effectiveness of antibiotics penicillin group.
Cases of an overdose of the drug Arthra are not known.
Shelf life: 5 years, if the temperature is 10-30 ° C.
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The closest synonym of the preparation Arthra has the same active substances. The difference between these drugs is the dosage of chondroitin - one capsule of Teraflex includes 500 mg of glucosamine and 400 mg of chondroitin.
Pharmacology, contraindications, interaction with other drugs and side effects are similar.
Two types of tablet forms of this drug are produced: Teraflex and Teraflex Advance.
Their main difference is that in Teraflex Advance there is still a non-steroidal anti-inflammatory agent ibuprofen. Classic Teraflex, as a rule, is used for the treatment of a chronic form of the disease, and Teraflex Advance - with considerable soreness of the joints (form of exacerbation). Chondroitin and glucosamine increase the effectiveness of ibuprofen, so Teraflex Advance has a more pronounced anti-inflammatory and pain-relieving effect. Since ibuprofen has many contraindications to use, Teraflex Advance can not be assigned to every patient.
Overdose can occur: vomiting, pain in the abdomen, dizziness, fainting, insomnia, hypertensive syndrome, hepatic (renal) insufficiency, necrosis of the liver.
To eliminate the consequences of taking a dose of the drug, which significantly exceeds what was shown, it is necessary to rinse the stomach.
Shelf life: 3 years if the temperature is 17-25 ° C.
The active substance of this drug is glucosamine sulfate.
This remedy compensates for the lack of glucosamine, a raw material for the repair of cartilaginous tissue, which activates the activity of chondrocytes. Glucosamine stimulates the production of the main components of the cartilage and subsequently protects it from destruction, causing a natural regeneration of the joint tissues.
Produced in 750 mg tablets and 250 mg capsules for oral administration. Tablets are taken in the morning and evening during a meal, with a glass of water. Capsules should be taken at 4-6 per day.
Improvement of the condition becomes noticeable 2-3 weeks after the start of application. The minimum duration of admission is 4 weeks. Repeated course - if necessary with interruptions in two months.
Shelf life: 2 years if temperature conditions are observed up to 25 ° C.
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Contains the active substance - chondroitin sulfate, which promotes the regeneration of cartilage tissues, saturating them with water by increasing the ability of proteoglycans to absorb water.
The effect of the drug is to delay the excretion of calcium, accelerate the repair of cartilaginous tissue and support the natural structure of its matrix.
The recommended daily therapeutic dose is 1000 mg, with maintenance therapy the dose is prescribed personally. The intake of the drug is independent of eating. Capsules must be taken as a whole, with enough water. The duration of the course of treatment with Structum is 3-6 months. After 2-5 months, you can appoint a second course if necessary.
Shelf life: 3 years if temperature conditions are observed up to 25 ° C.
In complex therapy in the treatment of arthrosis, you can use the "Biolika" health products made from ecologically pure plant raw materials that do not have synthetic ingredients.
Arthro-Biol is a tonic and restorative. Has an active anti-inflammatory, bactericidal and antipyretic effect. Helps normalize blood pressure and reduce serum cholesterol concentration. Helps cleanse the blood, weaken the pain syndrome, splice bones, increase the elasticity, elasticity and strength of the walls of blood vessels.
It is saturated with vitamins (C, P, B1, B2, E, K, B6), provitamin A, minerals - iron, copper, boron, manganese, molybdenum, fluorine, potassium, phosphorus, calcium, pectin and tannins.
It is used in the complex treatment of diseases: osteochondrosis, arthritis, arthrosis, gout, urolithiasis, cholelithiasis, water-electrolyte imbalance.
The drug consists of the fruits of black chokeberry and rosehip, cowberry leaves, the herb of the mountaineer and the horsetail of the field, the roots of elecampane and burdock.
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Silicono-Biol has astringent, hemostatic effect, contributes to the rapid healing of wounds. It is a strong diuretic, antispasmodic, bactericidal. Oppresses the inflammatory process, dilates the blood vessels, normalizes the heart rate. Positively affects the metabolic processes, promotes the assimilation of the vitamin-mineral complex, increases immunity.
It contains salts of silicic acid and potassium, flavonoids, bitterness, saponins, carotene, resins, tannins, vitamins B, C and provitamin A.
It is used in the complex treatment of osteochondrosis, arthrosis, atherosclerosis, urolithiasis, as well as metabolic disorders, intoxications, skin, teeth, hair, nails, and bones.
The preparation consists of kaolin, horsetail grass, sporach and wheatgrass, chicory root, bean leaves, nettle leaves, silicon oxide.
Calcio-Biol has antipyretic, choleretic and sedative ability. It shows an anti-carcinogenic and anti-sclerotic effect on the body. It dilates blood vessels, renews blood composition, strengthens immunity and protects the body from free radicals.
Calcio-Biol contains calcium citrate - a source of organic calcium, vitamins (C, A B2, E, PP), taraxanthin, flavoxanthin, choline, saponins, resins, plant protein, salts of iron, manganese, calcium, phosphorus.
Used in the complex treatment of dysfunctions of the musculoskeletal system, incl. Rickets; osteochondrosis, cokearthrosis, bone fractures, paradontosis, atherosclerosis, allergies, convulsive syndrome, and also for the healing of hair, teeth, bones.
The preparation consists of an extract of dandelion, ascorbic acid, vitamins of group D, calcium citrate, sodium polyphosphate, selenium and magnesium oxides.
To use as follows:
All listed biological preparations should be taken orally. Adults take two tablets three times a day for half an hour before meals, washed down with a small amount of water. The health course should last from 8 to 12 weeks. The repeated course of taking the drug can be done after 2 or 3 weeks.
- hypersensitivity to the components of the drug;
- age up to 14 years;
- pregnancy and lactation.
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The active substance of this drug is escin. It is a mixture of triterpene saponins from horse chestnut seeds, slightly toxic and highly soluble in water.
Aescin's ability to relieve inflammation is to maintain the integrity of the lysosome membranes, limiting the release of lysosomal enzymes that contribute to lethal cell damage and destroy proteoglycan. Reduces the permeability of the walls of arterioles, capillaries, venules.
Applied in complex therapy for arthrosis as a highly effective angioprotector.
Absorbed tissues by about 11%. It is excreted with bile and urine.
Contraindicated in hypersensitivity, renal failure, in the first trimester of pregnancy and lactation. According to the indications, Aescin is not excluded in the second and third trimester of pregnancy.
Occasionally, there may be nausea, fever, tachycardia, skin rash.
Aescin increases the effect of anticoagulants, with antibiotics (aminoglycoside series, cephalosporins), toxic effects are possible.
Tablets should be taken after eating, drinking a glass of water - 40 mg / 3 times a day, maintaining a dose of 20 mg / 2-3 times a day. Tablets of prolonged action are taken 2 times a day. The maximum dosage is 120 mg / day.
Shelf life: 3 years if the temperature is 15-25 ° C.
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Anesthetics for arthrosis
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The active ingredient is acetylsalicylic acid.
Has anti-inflammatory, antipyretic, analgesic activity, prevents the formation of blood clots.
It is used in case of pain and febrile syndrome; with pathologies of connective tissue; for the prevention of thrombosis, embolism, myocardial infarction.
To achieve the analgesic effect, tablets are used that contain 0.5 g of acetylsalicylic acid.
Daily intake for adults up to 3 grams, divided into three doses. Duration of treatment - no more than two weeks.
Possible side effects: a feeling of nausea, lack of appetite, tenderness in the upper abdomen, tinnitus, various manifestations of allergies up to asthmatic.
Long-term use can cause gastritis and duodenitis.
Contraindicated in the use of ulcer in the gastroduodenal region; thrombocytopenia; renal and hepatic dysfunction; bronchial asthma; under the age of 15, pregnant. It is not used concomitantly with drugs that prevent thrombosis.
When lactation is acceptable, the appointment of aspirin in medium doses.
Not compatible with alcohol.
Keep in a place protected from moisture for no more than 4 years.
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Non-steroidal anti-inflammatory drug. In diseases of joints reduces their soreness both in a stationary state and in movement, partially eliminates the stiffness and swelling of the joints after sleep, promotes an increase in motor activity. It inhibits the activity of cyclooxygenase, as a result of which inflammatory and pain symptoms are eliminated.
Ketoprofen provides anesthesia by slowing the synthesis of prostaglandins in the central and peripheral nervous system, as well as reducing the conductivity of the spinal tracts, providing perception of pain signals and the formation of pain sensitivity. This drug is a powerful bradykinin blocker that lowers the pain threshold, stabilizer of lysosomal membranes, which prevents the entry of lysosomal enzymes into the joint fluid. Prevents thrombosis.
Oral reception provides ketoprofen good absorption from the gastrointestinal tract, the greatest accumulation of it in the blood plasma is observed after 1-2 hours.
Excretion, mainly with urine, less than 1% is excreted with feces.
Indications for use:
- inflammatory-degenerative pathologies of joints;
- soreness in the spine;
- post-traumatic pain;
- trauma without complications;
- inflammatory diseases of veins and lymph nodes (in complex therapy).
- exacerbation of erosive and ulcerative diseases of the gastroduodenal zone;
- allergy to NSAIDs,
- dysfunction of the liver, kidneys;
- for women: the last three months of pregnancy and lactation;
- adolescence up to 15 years.
The dosage of the drug is chosen by the attending physician, taking into account the severity of the disease. Adults take 0.3 g per day, divided into 2 or 3 doses.
Joint use of ketoprofen with other NSAIDs increases the likelihood of erosive and ulcerative complications of the gastrointestinal tract and hemorrhages; with hypotensive drugs - weakening their effectiveness; with thrombolytics - the probability of hemorrhages.
Joint reception with aspirin inhibits ketoprofen's connection with blood plasma proteins, increasing the rate of blood purification from this drug; with heparin, ticlopidine - the probability of hemorrhages; with lithium preparations - can be intoxication with lithium due to its delay in the tissues of the body.
Joint reception with diuretics increases the risk of kidney dysfunction.
Joint reception with probenecid slows the removal of ketoprofen from the body; with methotrexate - enhances the undesirable effects of this drug.
A joint reception with warfarin provokes severe hemorrhages, sometimes with a fatal outcome.
For vital indications in the first 6 months of pregnancy, ketoprofen can be used taking into account the possibility of potential complications for the fetus.
Side effects of ketoprofen:
- pain in the epigastric region;
- dyspeptic phenomena;
- dysfunction of the digestive organs (occasionally erosive and ulcerative pathologies of the gastroduodenal zone with hemorrhagic manifestations and perforations);
- allergy (rashes, occasionally - spasm of the bronchi);
- headache, dizziness, drowsiness.
Store for 5 years, observing the temperature regime up to 25 ° C. Keep away from children.
The active substance is diclofenac sodium. It belongs to non-salicylate non-steroidal anti-inflammatory drugs.
It is able to relieve inflammation, febrile and painful syndrome, inhibiting the biosynthesis of prostaglandins causing morbidity and swelling in the epicenter of inflammation.
With collagenosis reduces inflammation, soreness, enslavement and swelling of the joint, especially in the morning, improving its functioning.
With traumatic lesions and after operations, diclofenac helps to reduce soreness and removes puffiness.
Absorbed by the tissues of the body quickly, the highest concentration after ingestion is observed after 2-3 hours and is proportional to the dose taken. The presence of food in the stomach inhibits absorption for 1-4 hours and accumulation by 40%.
50% of the taken agent is absorbed, which almost completely penetrates into the blood plasma, connecting with the albumins, and into the synovial fluid, where the highest concentration is formed later, and accumulates longer than in the plasma.
Metabolic products are excreted 65% in urine, up to 1% with feces, residual - with bile.
Diclofenac is used for:
- pathologies of the locomotor system of different etiology;
- inflammatory-degenerative pathologies of joints;
- moderate pain sensations of different etiology;
Diclofenac is contraindicated in:
- exacerbations of erosions and ulcers of the gastroduodenal zone (including hemorrhages);
- allergies to NSAIDs,
- violation of the process of hematopoiesis;
- violation of the process of blood clotting;
It is not prescribed for pregnant women and nursing mothers, as well as for preschool children (up to 6 years of age).
Caution should be exercised when prescribing diclofenac to patients over 65 years of age, persons with a history of anemia, bronchial asthma, ischemic heart disease, high blood pressure, edema, hepatic and renal dysfunctions, alcoholism, gastroduodenitis, erosion and gastroduodenal ulcer in remission; diabetics and postoperative patients.
Use, without shredding, with food or after eating, with a glass of water. Dosage for adults and adolescents older than 14 years - from 25 to 50 mg two or three times a day. The maximum permissible dose is 150 mg per day.
At the onset of a satisfactory state of health, the dosage of the drug is gradually reduced to switch to the use of 50 mg per day.
Children over 6 years of age are expected to receive up to 2 mg of the drug per 1 kg of the body weight of the child for use in 2 or 3 doses.
An overdose of diclofenac can cause vomiting, dizziness, headache, shortness of breath, dizziness; in childhood - high convulsive readiness, nausea, abdominal pain, hemorrhage, hepatic and renal dysfunction.
Emergency help when exceeding the dosage consists in washing the stomach and taking adsorbents.
Joint use with digoxin, methotrexate, lithium preparations and cyclosporins increases their absorption by blood plasma, increasing toxicity; with diuretics - reduces their effectiveness, with potassium-sparing diuretics - the possibility of hyperkalemia.
Reduces the degree of hypoglycemic, hypotensive and hypnotic drugs.
Co-administration with cephalosporins, valproic acid can cause a deficiency of prothrombin, with cyclosporins and drugs containing gold, can cause kidney intoxication.
Joint use with aspirin reduces the absorption of diclofenac, with paracetamol stimulates a possible manifestation of toxic effects on the kidneys of diclofenac.
The possibility of hemorrhages (often gastroduodenal) is increased when used in conjunction with:
- other NSAIDs;
- adrenocorticotropic hormone;
- preparations containing St. John's wort.
Diclofenac activates the properties of drugs that stimulate photosensitization
Co-administration with tubular secretion blockers contributes to increased toxicity of diclofenac.
The use of this medication can cause the following side effects listed below.
Most often they occur in the area of the digestive system: abdominal tenderness, the accumulation of gases in the intestine, stool disorders, nausea, flatulence, increased AST and ALT in the blood, peptic ulcer complicated by hemorrhagic manifestations or perforations, gastroduodenal bleeding, yellowing of the skin, tarry stools and etc.
Less common disorders of the nervous system, sensory organs, there may be rashes on the skin, partial or complete hair loss, an abnormal reaction to sunlight, pinpoint bruises.
There may be acute renal failure, nephrotic syndrome, the appearance of protein and / or blood in the urine, inhibition of urine formation, interstitial nephritis, necrotic papillitis.
Sometimes the use of diclofenac react hemopoietic organs by lowering the level of hemoglobin, leukocytes, platelets, granulocytes, increasing the number of eosinophils or the immune system - exacerbation of infectious processes.
Side effects can be manifested by coughing, bronchial spasm, laryngeal edema, atypical inflammatory processes in the lungs, hypertension, myocardial weakness, extrasystole, chest pains.
As manifestations of hypersensitivity to diclofenac, anaphylactic and anaphylactoid reactions are observed.
Patients taking diclofenac should not engage in activities that require concentration and quick response. Not compatible with alcohol.
Keep no more than three years, observing the temperature regime up to 25 ° C, in a dark dry place. Keep away from children.
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It is an active non-steroidal anti-inflammatory drug. Has the ability to relieve inflammation, febrile syndrome and pain, inhibiting the biosynthesis of prostaglandins, causing pain and swelling in the epicenter of inflammation.
Pharmacological properties, indications and contraindications for use are generally similar to diclofenac tablets.
Indomethacin tablets are not given to women during pregnancy and lactation, as well as to children under 14 years of age.
- dyspeptic disorders;
- pain in the abdominal region;
- erosion, ulcers, hemorrhages and perforations of the gastroduodenal zone;
- catarrhal, allergic stomatitis;
- inflammatory-dystrophic changes in the gastric mucosa;
- toxic-allergic liver damage;
- dizziness, depression, drowsiness;
- mental disorders;
- violation of heart rate and heart rate;
- arterial hypertension or hypotension;
- thrombohemorrhagic syndrome, decreased blood clotting;
- dysfunction of hearing and sight;
- renal dysfunction;
- occasionally - intestinal obstruction.
Use, not crushing, with or after a meal. It is better to wash down with milk. Begin with 25 mg two or three appointments per day. In the absence of a satisfactory therapeutic effect, the dosage is increased by 50 mg three or four doses per day. The maximum permissible daily intake is 200 mg. Duration of treatment is at least 4 weeks.
With prolonged use, the maximum permissible daily intake is 75 mg.
Overdose can manifest as dyspepsia, severe headache, forgetfulness, dysfunction of the vestibular apparatus, numbness of limbs, convulsions.
Co-administration of indomethacin with other drugs:
- reduces the effectiveness of diuretics, beta-blockers;
- improves the effectiveness of anticoagulants of indirect action;
- with diflunizalom possible hemorrhagic syndrome in the gastroduodenal zone;
- with probenecid, the accumulation of indomethacin in the blood plasma increases;
- with methotrexate and cyclosporine, the toxicity of these drugs increases;
- with digoxin, the accumulation of digoxin in the blood plasma is likely to increase and the half-life of the digoxin is increased;
- at a dosage of indomethacin 150 mg, lithium accumulation in the blood plasma increases and its excretion is inhibited.
Store 3 years, observing the temperature regime up to 25 ° C, in a dark place. Keep away from children.