Sumamed with angina

The drug has a wide range of effects. Is azalide - an antibiotic from the macrolide category. Doctors recommend taking Sumamed in angina, as it can effectively fight any types of this disease. Antibiotic has a bactericidal effect on highly concentrated inflammation.

[1]

Indications of the sumamed with angina

Among the indications for the use of drugs: inflammations having an infectious nature, provoked by bacterial strains sensitive to Sumamed. These are diseases of the upper respiratory tract - such as angina, etc.

When does Sumamed start to help with sore throat?

Sumamed's action in the treatment of sore throat starts rather quickly - symptom relief occurs after 1-2 medications, i.e. Already on the 1st / 2nd day.

[2], [3], [4], [5]

Release form

The drug is given in capsules or tablets (adults) and suspensions for syrup (for children). One package contains 3 or 6 tablets, and in the form of capsules - 6 pcs. The syrup is sold in a 100 ml vial.

Pharmacodynamics

Active component of Sumamed is azithromycin. The following Gram-positive cocci are sensitive to this substance: pneumococcus, Streptococcus pyogenes, and Streptococcus agalactiae, in addition to streptococci in the CF groups, as well as G, Staphylococcus aureus and Streptococcus viridans. Gram-negative microorganisms are also sensitive: gram-negative influenza, Moraxella catarrhalis, pertussis and Bordetella parapertussis along with Haemophilus ducrei, Legionella pneumophila, Campylobacter vernalis, Gonococcus and Gardnerella vaginalis. Among anaerobes sensitive are: Clostridium perfringens and Bacteroides bivius with peptostreptococcus spp. Azithromycin also acts on Chlamydia, Mycoplasma pneumoniae, Ureaplasma urealiticum, pale treponemia and Borrelia burgdoferi. In this case, azithromycin has no effect on gram-positive microorganisms, which are resistant to the substance erythromycin.

[6], [7], [8]

Pharmacokinetics

Absorption of azithromycin is carried out from the gastrointestinal tract and is quite fast. This is due to the fact that the substance is lipophilic and resistant to acidic medium. When 500 mg of azithromycin is used, the peak in the blood plasma reaches 2.5-2.96 hours (the rate is 0.4 mg / l). The bioavailability index is 37%.

Azithromycin effectively affects the respiratory system, as well as the urogenital system (including the prostate), soft tissue and skin. The indicators of the increased concentration of the substance in the tissues (10-50 times higher than those in the blood plasma), as well as the long half-life of it, are due to the fact that azithromycin does not bind well to plasma proteins. In addition, it is affected by the fact that it is able to pass into nuclear cells, accumulating in the surrounding lysosome with a low-acid medium. As a result, the volume of distribution reaches 31.1 l / kg and the clearance in the plasma rises.

The fact that azithromycin can largely accumulate in lysosomes is very important when destroying intracellular stimuli. Through phagocytes, azithromycin enters the location of the bacterial infection and is released there by phagocytosis. The substance accumulates mainly in the foci of inflammation (exceeds the concentration in healthy cells by 24-34% on average) in relation to the degree of puffiness at the site of the lesion. Although azithromycin has a high accumulation rate in phagocytes, it does not significantly affect their functioning.

Bactericidal accumulation of matter on the inflamed area is maintained for 5-7 days. After the use of the last dose, as a result of which it became possible to develop short-term (3-5 days) medical courses.

Azithromycin is excreted from the blood plasma in 2 stages: the half-life is 14-20 hours with an interval of 8-24 hours after the use of drugs and 41 hours with an interval of 24-72 hours, so that Sumamed can be consumed 1 rub. / Day.

[9], [10]

Dosing and administration

Adults Sumamed with angina are prescribed courses in 5 or 3 days. At the first variant it is necessary to use 500 mg of the drug on the first day, after that to reduce a dosage to 250 mg and to accept in such amount the remained 4 days. At the second variant it is necessary to drink all 3 days on 500 mg (thus, the general or common dose for a course will make 1,5 g).

Sumamed with herpes, follicular and purulent angina

The drug successfully copes with these forms of angina, it can be prescribed to both adults and children.

[17], [18]

Sumamed with angina in children

Infants up to 6 months. A drug suspension should be given. To make a syrup out of it, you need to dissolve 17 g of powder in 12 ml of water - the volume of the liquid should be 23 ml. The bottle must be shaken well before use.

Children over 3 years are allowed to give tab. For 125 mg. The tablet dose of the drug is calculated in a ratio of 10 mg / 1 kg of the weight of the baby.

In case of angina caused by the virus Streptococcus pyogenes, it is necessary to increase the dosage of Sumamed - 20 mg / kg with a 3-day treatment course or 12 mg / kg with a 5-day treatment course. In general, the child should drink 60 mg / kg of medication per course.

Use of the sumamed with angina during pregnancy

Use of medicines during pregnancy or during breastfeeding is allowed only in exceptional cases, if the benefit of using the medicine exceeds the risk existing for the baby.

Contraindications

Among the contraindications:

• Intolerance to azithromycin, macrolides and other components of drugs;
• Severe impairment in the function of the kidneys or liver failure in severe form;
• Capsules and tablets in a dosage of 500 mg - for children under 12 years (weighing less than 45 kg), tablets in a dosage of 125 mg for children under 3 years, suspension for a child younger than 6 months;
• Lactation period;
• Reception in combination with ergotamine or dihydroergotamine.

With caution, it is necessary to appoint in the case of arrhythmias, the presence of abnormalities in the work of the kidneys and liver, as well as with myasthenia gravis.

[11], [12], [13]

Side effects of the sumamed with angina

Adverse reactions to the medicine develop very rarely. Basically, they appear in this form: vomiting with nausea and diarrhea, as well as flatulence or constipation. Appetite may also worsen, allergies may occur (rashes on the skin, hives, angioedema, edema), sleep problems, feelings of anxiety, headaches, etc.

[14], [15], [16]

Overdose

In case of an overdose, the patient may experience nausea with vomiting, diarrhea, abdominal pain, liver problems, and temporary loss of hearing.

[19], [20]

Interactions with other drugs

Antacids (including those containing magnesium and aluminum), and in addition, food and alcoholic beverages significantly weaken Sumamed's absorption, as a result of which the drug should be consumed separately with these substances and food (drink Sumamed at least 1 hour before meal or 2 hours after).

In addition, you should carefully combine drugs with antiaggregants and anticoagulants. If you use warfarin, you should monitor prothrombin time. It is forbidden to drink Sumamed in combination with heparin.

[21], [22], [23]

Storage conditions

To keep medicine is required in a place inaccessible to children, closed from light and dry. Temperature conditions are within 15-25 ° С.

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Shelf life

Tablets with capsules are allowed to use for 3 years, the powder for the preparation of oral syrup - for 2 years. Ready suspension can be stored for no more than 5 days.

Reviews

Sumamed in angina is a fairly popular and effective drug, which is often prescribed for the treatment of this disease. Reviews about it leave both patients and doctors.

Tatyana: "As a medical worker, I would like to recommend not to abuse antibiotics, including Sumamed, although in most cases it is very effective. I advise you to use it only when other medicines do not work. As with all antibiotics, the use of Sumamed is fraught with adverse reactions, so you should consult with a doctor before taking any medication. The advantages of this medication are its price, as well as the speed of exposure. A positive factor can be called and that the medicine is required to drink only once a day, so it is difficult to forget about it or get confused about the number of receptions. "

Masha: "The medicine is really good, it is checked on own experience. I got sick with angina, I was treated for 2 weeks without results, after which my doctor wrote to me Sumamed. Since the illness I had in a neglected form, prescribed a dose twice a day, although under the instruction it is taken only once, and before meals (for 1 hour) or after it (after 2 hours). The diet was not normal, so I drank the medicine 2 hours after eating. The doctor warned that if side effects occur, you need to go to the standard procedure. But I had no problems, so I drank the medicine twice a day. I recovered pretty quickly. "

Nastya: "It was not once once convinced that Sumamed is very effective in cases of angina. Since I myself am sick with this disease quite often, I tried many medications. When pus appeared, it was Sumamed that was most effective. Given that the duration of treatment with this drug is only 3 days, it can be considered the most suitable for the rapid elimination of angina. "