Stenotrol solutub

Ceforal Solyutab has bactericidal and antibacterial activity.

Indications Stenotrola solutub

It is used for therapy in diseases that are infectious and inflammatory in nature and are provoked by the activity of bacteria that are susceptible to drugs:

• lesions in the respiratory tract or upper respiratory tract;
• acute form of gonorrhea, without complications;
• acute or chronic stages of infections in the area of the urethra.

Release form

The release of the substance is in the form of dispersible tablets. Inside the box contains 1, 5, as well as 7 or 10 tablets.

Pharmacodynamics

The active element of the drug is an antibiotic from the 3rd generation of cephalosporins.

The principle of therapeutic effect is based on the ability of the destruction of the peptidoglycan binding processes, which is the main structural part of the cell membrane of pathogenic bacteria. The drug is resistant to the influence of β-lactamase, and in addition it demonstrates a bactericidal effect against a large number of gram-negative and positive microbes.

During clinical tests, Ceforal Soluteb showed activity in relation to bacillus influenzae, pyogenic streptococcus, Proteus mirabilis, and in addition pneumococcus, gonococcus, Escherichia coli, and moraxella catarallis.

Microorganisms that die under the influence of drugs:

• gram-positive - streptococcal agalactia and pneumococcus;
• Gram-negative - gonococcus, ordinary protei, moraxella cataralys, and besides inflorescences, celbecaras, salmonella, shigella with providence, citrobacter amalonaticus, klebsiella, octopus, salmonella, shigella with providence, citrobacter amalonaticus, klebsiella

At the same time, the drug does not affect enterobacteria, pseudomonads, serration, listeria monocytogenes, clostridia with staphylococci, fragilis bacteroids and enterococci.

Pharmacokinetics

After oral administration, approximately half of the active element is absorbed inside the gastrointestinal tract. When used with food, the suction time increases by about 0.8 hours. After 2-6 hours, antibiotic serum levels are around 65%.

Almost half of the drug component is excreted through the kidneys during the day. The half-life of blood plasma is within 3.5-9 hours.

It is necessary to take into account that in elderly people the equilibrium values of AUC are higher than those of other categories of patients, by 40%.

In persons with renal diseases (the level of QC is 30 ml / minute) the half-life of drugs is extended to 6 hours. With KK values within 6-20 ml / minute - it is prolonged up to 11.5 hours.

Dosing and administration

The duration of therapy and the size of servings are selected by the attending medical specialist. After the appearance of improvements, it is required to continue the use of tablets for another 2-3 days.

The pill is drunk either by swallowing it whole and drinking it with plain water, or after it is dissolved in water. Dissolved medication is required immediately. Taking medication is allowed without reference to the use of food.

The use of drugs for adults or adolescents over 12 years of age (weight more than 50 kg).

The size of the daily portion is usually 400 mg (corresponds to the 1st tablet of the drug). A pill is taken at one time or divided into 2 uses.

The therapeutic cycle lasts 7-10 days.

In the treatment of uncomplicated gonorrhea, use 1-fold 1-well pill of the drug (0.4 g).

Children under the age of 12 years.

The size of the daily dose is calculated by the ratio of 8 mg / kg. It is necessary to drink the medicine 1 times a day. There is also a scheme with the use of drugs in a dose of 4 mg / kg 2-fold per day - with a 12-hour interval.

For diseases provoked by the activity of pyogenic streptococcus, the duration of Ceforal solutab should be at least 10 days.

In case of renal pathologies, when the level of CC is equal within 21-60 ml / minute, or when the patient is undergoing hemodialysis, the daily portion is reduced to 75% of the standard. With CC values below 20 ml / minute, or for patients undergoing peritoneal dialysis, the daily dosage is halved.

Use Stenotrola solutub during pregnancy

Currently, there is not enough information regarding the use of Ceforal Soljutab during pregnancy. Because of this, it is allowed to appoint him only with vital indications and after discussing this issue with the treating physician.

At the time of taking the drug should abandon breastfeeding.

Contraindications

Main contraindications:

• porphyria;
• the presence of intolerance towards cefixime (cephalosporins or penicillins) or the rest of the drug;
• history of hypersensitivity, epidermal rash or urticaria;
• AND.

Side effects Stenotrola solutub

Taking the pills may cause such side effects as:

• thrombocytopenia, agranulocytosis, such as eosinophilia or leucopenia;
• anemia, which has a hemolytic nature, epidermal necrolysis, fever, Stephen-Johnson syndrome and erythema;
• blood coagulation disorders;
• an increase in liver enzymes;
• itching, urticaria, allergic manifestations or PETN (you must immediately cancel the use of the drug);
• nausea, feeling of weakness, dystrophy, and besides this loss of consciousness and headaches;
• pain in the area of epigastrium, vomiting, disorders of the digestive processes, indigestion, bloating and diarrhea;
• jaundice or hepatitis;
• candidiasis, vaginitis, or itching in the genital area.

Overdose

In case of overdose, an increase in the multiplicity of development of negative manifestations may be observed.

Gastric lavage, as well as symptomatic and supportive measures, are required to correct the impairment. The medication does not have an antidote, and the procedures for peritoneal dialysis or hemodialysis will be ineffective.

Interactions with other drugs

Probenecid, as well as other substances that block the secretion of tubules, increases the blood values of the antibiotic and inhibits its excretion, which can cause intoxication.

Under the influence of the drug may increase the blood rate of carbamazepine. When using Ceforal Solyutab along with carbamazepine, it is necessary to monitor the blood values of the latter.

Furosemide, as well as aminoglycosides when combined with the drug increases the load on the kidneys.

Caution should be used with nifedipine or salicylic acid.

During the passage of the Coombs test during the use of cephalosporins, a false-positive response may occur.

The process of cefixime absorption inside the gastrointestinal tract can be inhibited by magnesium- or aluminum-containing antacids.

The combination of medication and warfarin or anticoagulants may increase the values of PTH, but there are usually no clinical symptoms (bleeding).

Tests regarding the indicators of sugar inside the urine (this refers to the test tablets of copper sulfate, as well as to the solutions of Benedict or Fehling) do not show reliable data if at the time of their performance the patient used Ceforal Soluteb.

Under the influence of drugs, there may be a decrease in the drug efficacy of estrogens, as well as combined oral contraception.

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Storage conditions

Ceforal Solyutab must be kept out of the reach of small children. Temperatures maximum 25 ° C.

Shelf life

Ceforal Solyutab can be used within 36 months from the date of manufacture of the pharmaceutical agent.

Analogs

Analogues of the medication are the medicines Suprax Solutab, Cefix with Lopraks, Sorcef with Vinex, and in addition Flamyfix, with Ikzym and Cefixime.

Reviews

Ceforal Solyutab gets mostly good reviews. Many patients say that it has a very large range of therapeutic activity, which makes it extremely popular. It is noted that the drug for only 1 application allows you to eliminate gonorrhea.

There are also positive comments regarding the use of drugs for cystitis.

Among the disadvantages is the frequent appearance of negative symptoms; These are usually signs of intolerance and indigestion.