Soothing Collection No. 3

The mixture of medicinal plants Calming collection No. 3 is a herbal preparation with hypnotic and sedative effects. Trade names: Calming collection No. 3 (sedative), Fitosedan 3.

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Indications of soothing collection number three

The collection has the following indications for use: excessive nervous excitability, neurasthenic conditions (including menopausal), insomnia, initial stages of arterial hypertension, gastrointestinal spasms.

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Release form

The release form of Soothing Collection No. 3 is a dry mixture of crushed medicinal plants or filter bags of 2 g (10-20 bags in each pack). Fitosedan 3 is released in the form of filter bags.

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Pharmacodynamics

100 g of Soothing Collection No. 3 contains: 25 g of motherwort herb (herba Leonuri cardiaca), 25 g of oregano herb (herba Origanum vulgare), 25 g of thyme herb (herba Thymus serpyllum), 17 g of valerian rhizome and root (radix Valerianaе), 8 g of sweet clover herb (herba Melilоtus officinalis). The herbal preparation Fitosedan 3 has an identical composition.

The pharmacodynamics of these sedatives is based on the action of the following medicinal plants:

• motherwort herb contains flavonoids and glycosides (quercetin, quinqueloside, rutin, stachydrine), monoterpene glycosides (iridoids), P-coumaric acid, which have a calming effect on the body, lower blood pressure, reduce heart rate, but at the same time increase it, thereby dilating the coronary vessels;
• the sedative effect of oregano is due to a combination of biochemical processes occurring in the body under the influence of substances in its composition, but the monoterpene alpha-thujone is particularly distinguished, the psychotropic effect of which resembles the effect of tetrahydrocannabinol (contained in hemp), which blocks GABA and serotonergic receptors in the brain;
• in thyme herb, monoterpene alcohols act directly on the central nervous system, in particular, borneol, which reduces blood pressure;
• Valerian roots also contain borneol, the effect of which on the body is enhanced by bornyl isovalerate, valerianic and isovaleric acids, as well as the anxiolytic effect of isovaltrate, which acts as an antagonist of adenosine A1 reuptake receptors;
• Sweet clover grass contains CNS depressant coumarins and triterpene glycosides (melitoside) with antioxidant activity.

Pharmacokinetics

The pharmacokinetics of herbal medicinal preparations are not presented in the instructions.

Dosing and administration

Soothing collection No. 3 and Fitosedan 3 are taken orally, for which a water infusion is prepared from the plant material, and herbal tea is brewed from a filter bag. For a glass of boiling water, take 10 g of loose collection or one filter bag.

The recommended doses (one third of a glass once or twice a day) should be adjusted with the attending physician - in accordance with the diagnosis and the condition of the individual patient.

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Use of soothing collection number three during pregnancy

Contraindicated

Contraindications

In the instructions for Soothing Collection No. 3, the only contraindication for use was hypersensitivity to the ingredients of the collection. The manufacturers of the identical in composition herbal tea Fitosedan 3 also indicated children under 12 years of age and, very importantly, noted that use during pregnancy and breastfeeding is contraindicated.

However, the instructions do not contain any information regarding:

• Motherwort is contraindicated in cases of bradycardia (decreased heart rate) and low blood pressure;
• Herbal preparations containing oregano are not recommended for men, as well as for those who have problems with gastric acidity or have a stomach ulcer;
• Thyme is not recommended for use if there are serious problems with the heart, liver and kidneys;
• Valerian should not be used in the presence of chronic intestinal inflammation (enterocolitis), as well as in cases of increased blood clotting.

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Side effects of soothing collection number three

According to official instructions, the side effects caused by Soothing Collection No. 3 and Phytosedan 3 are expressed in allergic reactions.

However, it should be borne in mind that motherwort slows down psychomotor reactions and can cause an exacerbation of gastritis; oregano activates the digestive system and intestinal peristalsis; thyme increases the production of gastric juice.

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Overdose

Overdose may increase existing side effects (drowsiness and general weakness) and also cause depression. Since the metabolism of biologically active substances of herbal preparations has been little studied, sedative herbal teas should not be taken without the advice of specialists.

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Interactions with other drugs

Soothing collection No. 3 and Fitosedan 3, when used simultaneously with other sedatives or drugs of the cardiac glycoside group, increase their effect on the central nervous system and myocardium. Motherwort also enhances the effect of antiarrhythmic and anticonvulsant drugs.

Taking alcohol at the same time as taking a sedative is not allowed.

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Storage conditions

In a dry place, at a temperature of up to +27-28ºС, the finished infusion should be stored at a temperature of +12-15ºС.

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Shelf life

Dry raw materials are stored for two years, prepared water infusion – no more than two days.

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