Soothing collection №3

Mixture of medicinal plants Soothing collection №3 is a phytopreparation with hypnotic and sedative effects. Trade names: Soothing sediment 3 (sedative), Phytosedan 3.

[1]

Indications of the sedative collection №3

The collection has such indications for use as excessive nervous excitability, neurasthenic conditions (including climacteric conditions), insomnia, the initial stages of arterial hypertension, and gastrointestinal spasms.

[2], [3]

Release form

The form of the release of Soothing Collection No. 3 is a dry mixture of crushed medicinal plants or filter packs of 2 g (in each pack of 10-20 packets). Phytosedan 3 is released as a filter package.

[4]

Pharmacodynamics

100 g of Soothing Collection No. 3 contains: 25 g herb Leonurus cardiaca, 25 g herb herb Origanum vulgare, 25 g herb Thymus serpyllum, 17 g rhizome and root valerian (radix Valerianae), 8 g of herb grass (herba Melilotus officinalis). Phytodean 3 has the same composition.

The pharmacodynamics of these sedatives is based on the action of these medicinal plants:

• the motherwort herb contains flavonoids and glycosides (quercetin, quinqueloside, rutin, stachydrin), monoterpene glycosides (iridoids), P-coumaric acid, which soothingly act on the body, reduce blood pressure, reduce the heart rate, but at the same time strengthens them, while expanding the coronary vessels;
• sedative effect of oregano is due to a combination of biochemical processes taking place in the body under the influence of substances in its composition, but monoterpene alpha-thujone is especially different, its psychotropic effect resembles the effect of tetrahydrocannabinol (contained in hemp) blocking GABA and serotonergic receptors of the brain;
• in the grass of thyme directly on the central nervous system, mogoterpene alcohols act, in particular, borneol, which lowers the level of blood pressure;
• in the roots of valerian, there is also borneol, whose action on the body is enhanced by boronil-valerianate, valeric and isovaleric acids, as well as by the anxiolytic effect of isovalartrate, which acts as an antagonist of the adenosine A1 receptor reuptake;
• in the clover grass contains oppressive central nervous system coumarins and triterpene glycosides (melilotozide) with antioxidant activity.

Pharmacokinetics

Pharmacokinetics of medicinal plant charges are not provided in the instructions.

Dosing and administration

The sedative collection No. 3 and Phytosedan 3 are taken internally, for which a water extract is prepared from the vegetable raw material, and herbal tea is made from the filter package. For a glass of boiling water should be taken 10 g of loose bulk or one filter bag.

Recommended doses (one third of a glass once or twice a day) should be adjusted with the attending physician in accordance with the diagnosis and condition of the individual patient.

[9], [10]

Use of the sedative collection №3 during pregnancy

Contraindicated

Contraindications

In the instructions to the Soothing Collection No. 3, only the increased sensitivity to the ingredients of the collection was contraindicated. Producers of the same phyto-tea PhytoSedan 3 have also indicated the children's age to 12 years and, very importantly, noted that use during pregnancy and lactation is contraindicated.

However, there is no information in the instructions regarding the fact that:

• Leonurus is contraindicated in bradycardia (lower heart rate) and low blood pressure;
• collections containing herb oregano, is not recommended for men, as well as those who have problems with the acidity of gastric juice or have peptic ulcer;
• thyme is not recommended if there are serious problems with the heart, liver and kidneys;
• Valerian should not be used in the presence of a chronic form of inflammation of the intestine (enterocolitis), as well as with increased coagulability of the blood.

[5], [6],

Side effects of the sedative collection №3

According to official instructions, the side effects that cause Calming Collection No. 3 and Phytosedan 3 are expressed in allergic reactions.

However, it should be borne in mind that the motherwort slows the psychomotor reaction and can cause an exacerbation of gastritis; oregano activates the digestive system and intestinal peristalsis; thyme increases the production of gastric juice.

[7], [8]

Overdose

Overdose can exacerbate already existing side effects (drowsiness and general weakness), as well as cause a depressive state. Since the metabolism of biologically active substances of phytopreparations has been studied little, one should not take sedative dues without the recommendation of specialists.

[11], [12]

Interactions with other drugs

Soothing collection No. 3 and Phytosedan 3, while using other sedatives or drugs of the group of cardiac glycosides, increase their effect on the central nervous system and myocardium. Motherwort also enhances the effect of antiarrhythmic and anticonvulsants.

The intake of alcohol at the same time with soothing collection is unacceptable.

[13], [14]

Storage conditions

In a dry place, at temperatures up to + 27-28 ° C, the ready-made infusion should be stored at a temperature of + 12-15 ° C.

[15], [16]

Shelf life

Dry raw materials - stored for two years, cooked water infusion - no more than two days.

[17], [18], [19], [20]