Sodium thiosulfate

Sodium thiosulfate is a salt mixture of sodium with thiosulfuric acid, used to provide detoxification as well as antihistamine exposure.

[1], [2],

Indications of the sodium thiosulfate

It is used as an antidote in the case of salt poisoning of elements such as As with I, Hg and Br, and also Pb, and in addition, with intoxication with hydrocyanic acid or cyanides.

In addition, the drug is used to remove scabies, SLE, arthritis with neuralgia, as well as allergic pathologies.

[3], [4], [5],

Release form

The release is carried out in the form of a 30% solution for intravenous injection, 60% solution to remove scabies, and as a medicinal powder.

[6], [7], [8]

Pharmacodynamics

The drug forms harmless to humans compounds that have a weak toxicity, with elements such as halogens, cyanides, and in addition salts of heavy metals. For medicinal purposes, a solution of this substance is used as an antidote for phenols, I, aniline, Hg, mercury, Cr, cyanide, and benzene.

As a result of intoxication with compounds of elements Pb or Hg or As, non-toxic type sulfites are formed. If there is intoxication with hydrocyanic acid, as well as its salts, the detoxification process is carried out by removing cyanide. This element, with the participation of the rhodonase enzyme (which has the maximum effect inside the liver), is converted into a relatively non-toxic component of the thiocyanate ion.

The organism can also independently eliminate the dangerous effects of cyanide, but purification by the natural method is an extremely slow process, therefore the rodonase system does not have enough activity to perform detoxification in case of cyanide intoxication.

In order to activate the pediatric response, external sulfur donators (among them also sodium thiosulfate) are required to enter the body.

Anti-scratch effect of the drug is due to the fact that sodium thiosulfate, while inside the acidic medium, can disintegrate, forming sulfur with sulfur dioxide. Both these components have a disastrous effect on both adult itch and their eggs.

[9], [10], [11]

Pharmacokinetics

With intravenous injection of drugs, the substance is distributed within the extracellular environment. Excretion occurs with the involvement of the kidneys, the substance is excreted unchanged. The biological half-life is 0.65 hours.

[12], [13], [14], [15], [16]

Dosing and administration

The drug is administered intravenously, and can also be administered orally and externally.

External treatment is used in the treatment of scabies. To do this, use a 60% solution, which treats the skin on the trunk and extremities. After it has dried, the treated areas should be moistened using a 6% solution of hydrochloric acid.

Oral and intravenous drug use is prescribed for the detoxification procedure in case of poisoning.

Intravenously, the drug is administered in the form of a 30% solution. The portion size varies between 5-50 ml. The dose depends on the type of substance that caused the intoxication, as well as the severity of the poisoning.

Orally it is required to take the solution by 10%. A single serving is 2-3 g of substance.

Application of drugs for gynecological diseases.

To eliminate gynecological disorders, the drug is often used as an auxiliary element, supplementing the basic therapy.

Intravenous injection of the solution is used as an integral part of curative programs for endocrine infertility. In this case, the patient is injected with m / m Actovegin, and in addition, plasmapheresis is used, as well as transorbital type electrophoresis with the use of niacin.

To remove the cyst inside the ovary, the drug is used in combination with the Vishnevsky liniment, and in addition dimexidom or diclofenac.

During the treatment of the genital form of tuberculosis, the drug becomes an integral component of non-specific treatment: a woman must use enzyme drugs (lidazu or ronidazu), sodium thiosulfate, and antioxidants (tocopherol). The drug is administered intravenously in the amount of 10 ml with a multiplicity of days. For the entire therapeutic course should be made 40-50 infusion solution.

Sometimes the medicine is also used in the form of special microclysters. There are doctors who recommend using this method to eliminate adhesive processes in the pelvic area, as well as inflammation of the reproductive organs.

The procedure is carried out using a 10% solution. A single serving is 30-50 ml. Before you enter the medicine into the anus, you should warm up the solution in a water bath - you need to reach 37-40ºC. It should be borne in mind that this is not an enema cleansing type, so it is required that the substance is completely absorbed inside through the intestinal mucosa.

The use of a solution for the treatment of psoriasis.

This drug course continues for 5-12 days. The size of the daily portion is 10-20 ml (the more accurate figure depends on the weight of the patient, as well as the tolerability of drugs).

Before use, dilute the solution in plain water (100 ml). To remove the unpleasant aftertaste of the medicine, it is allowed to add a little lemon juice to the solution. The drug is best to drink at night, before going to bed. If a laxative effect is observed, the dosage should be reduced to 10 ml / day.

Oral sodium thiosulfate.

Oral reception is intended for the purification of lymph with blood flow. Thanks to this procedure, general health, nails with skin and hair are improved. In addition, the drug helps to eliminate depression and many allergic symptoms.

To clean the body, you should drink the solution in a dose of 0.5 ampoules for 10 days. The medicine must be dissolved in plain water (100 ml).

The first dose should be taken before breakfast (for 0.5-1 hour), and the second - before dinner (also for 0.5-1 hour or after 2 hours after it).

[22], [23], [24]

Use of the sodium thiosulfate during pregnancy

Prescribe the drug to pregnant women is allowed only if there are life indications. Animal tests regarding the effect of drugs on reproductive activity have not been carried out.

Now there is no information about whether sodium thiosulfate can cause a negative effect on the embryo if it is used during pregnancy. There is no information as to whether it has a negative effect on a person's reproductive capacity.

Contraindications

The main contraindication to the use of this medication is intolerance with regard to its active ingredient.

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Side effects of the sodium thiosulfate

The side effect of the drug is the symptoms of hypersensitivity. When IV injection of the solution, pain can occur on the site of the procedure of administration.

[18], [19], [20], [21]

Interactions with other drugs

Combination of the drug with drugs, with the metabolism of which the process of rationing is carried out, can cause a decrease in the effects of the latter.

Medicines that are part of the group of iodides or bromides, when combined with sodium thiosulfate, are not able to exert their medication.

It is forbidden to mix sodium thiosulfate inside the same syringe, as well as solutions of nitrites with nitrates.

[25]

Storage conditions

Sodium thiosulfate should be kept in a dark place inaccessible to children. The temperature conditions are within 18-20 ° C.

[26], [27], [28]

Special instructions

Reviews

Sodium thiosulfate, used for IV injections, receives positive feedback - it is considered extremely effective in intoxication, as well as when eliminating alcohol dependence.

The people who use the solution with psoriasis therapy respond positively about the medicine, for the elimination of gynecological diseases and allergic pathologies.

Also on the forums there are often reports of the effectiveness of using drugs as a good method for losing weight, as well as complete body cleaning. But at the same time, the testimonies of people who used the medicine for these purposes show that this method does not bring any particular result. The greatest thing they managed to achieve is cleaning the intestines from toxins and toxins.

[29]

Shelf life

Sodium thiosulfate is allowed to be used for 5 years from the date of release of the drug.

[30], [31]