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Secnidox
Last reviewed: 03.07.2025
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Secnidox is a new generation antiprotozoal drug that successfully combats various intestinal infections and many types of amebiasis.
Indications Secnidoxa
Diseases for the treatment of which Secnidox is used:
- hepatic amebiasis (caused by the dysenteric amoeba);
- intestinal amebiasis (caused by dysenteric amoeba);
- trichomonas urethritis (caused by vaginal trichomonas);
- trichomonas vaginitis (caused by Trichomonas vaginalis);
- bacterial vaginitis;
- giardiasis (caused by intestinal lamblia)
Pharmacodynamics
The drug belongs to the category of nitroimidazoles with a pronounced antibacterial effect. Secnidox has a bactericidal effect (most active against unicellular microorganisms such as: Trichomonas vaginalis, dysenteric amoeba and intestinal lamblia) and amoeboid (in the entire intestine) effect. The pharmacodynamic effect occurs as a result of the penetration of the active substance into the middle of the microorganism. There, thanks to the 5-nitro group, secnidazole is restored and cellular DNA begins to work. The microorganism cell dies due to damage to the structure of the spiral form, destruction of threads and suppression of the integrity of nucleotides. The drug helps to increase the resistance of the tumor to the effects on it, and the patient becomes especially sensitive to alcohol intake.
Pharmacokinetics
Once inside the body, the active substance penetrates the semi-permeable barrier between the blood and nervous tissue, and is then excreted into breast milk. Bioavailability is 80%, which makes the drug easy to take for patients and significantly simplifies the treatment regimen. Secnidazole is adsorbed in the gastrointestinal tract quite quickly without losing its properties.
Dosing and administration
Secnidox is taken immediately before meals, always drinking plenty of water. The dosage regimen for children and adults is different.
Adults:
For the treatment of trichomonas urethritis and vaginitis, as well as bacterial vaginitis, take 2 tablets of Secnidox once.
Two tablets of the drug should be taken once in the same way for acute amebiasis. If amebiasis is asymptomatic, has a cystic or focal form, the patient needs to take two tablets a day for at least three days.
To treat hepatic amebiasis, take 1.5 g of Secnidox every day for five days, dividing the dose into several doses.
If there is lamblia in the body, the dosage will be two pills once a day. The medicine should be taken for three days.
Children:
The drug is not intended for use by children under twelve years of age.
For the treatment of giardiasis, the drug is prescribed by subtracting the dose of 30 mg multiplied by one kg of body weight.
Secnidox is also used to treat acute intestinal amebiasis. In focal, cystic or asymptomatic forms of the disease, the drug is taken every day for three days, at a rate of 30 mg / kg of weight.
For the treatment of hepatic amebiasis in a child, Secnidox should be taken daily at a rate of 30 mg/kg of body weight for five days.
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Use Secnidoxa during pregnancy
There is no data on oral administration of the drug during pregnancy. Taking Secnidox during this period may have a teratogenic effect on the fetus.
The drug gets into the mother's milk and can harm the child. If it is necessary to use Secnidox during breastfeeding, lactation should be stopped immediately.
Contraindications
It is strictly forbidden to drink alcohol if you have been prescribed this medicine. If the patient's card contains a mention of blood dyscrasia, Secnidox should be discontinued, as reversible neutropenia is likely to occur. As a result, leukocytosis will increase, which will decrease as a result of discontinuing treatment.
Secnidox is not taken by lactating women and women during the entire gestation period, as well as by children under the age of twelve. The drug has no effect on the ability to drive a car or the speed of reflexes. If the patient has a history of hypersensitivity to any component of the drug, the drug should be replaced with another similar in effectiveness.
Side effects Secnidoxa
If the dosage of the drug is not observed or there is sensitivity to the components, an undesirable effect may occur:
- common: weakness;
- gastrointestinal system: metallic taste, inflammation of the oral cavity, disorders;
- circulatory system: decreased number of leukocytes, neutrophils;
- allergy: rash, redness.
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Overdose
It is possible that some side effects will increase if the dose prescribed by the attending physician is exceeded. For therapy, symptomatic treatment is carried out, since there is no specific antidote to Secnidox.
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Interactions with other drugs
Caution should be exercised when taking secnidazole simultaneously with indirect anticoagulants, as their combined use significantly increases the risk of bleeding.
The combination of secnidazole and disulfiram will cause paranoid reactions and psychosis. In addition, alcohol intake will cause a disulfiram-monopod reaction - abdominal cramps, nausea and vomiting, as well as dizziness.
The level of lithium in the body will increase when Secnidox is taken together with lithium preparations.
It is not recommended to take secnidazole with non-depolarizing muscle relaxants, such as vecuronium bromide.
If the drug is used to treat peptic ulcer disease, then in combination with amoxicillin, its activity against bacteria will increase.
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Special instructions
Reviews
1. The whole family took the drug, as we were diagnosed with giardiasis, which, unfortunately, was confirmed after tests. We strictly followed the dosage prescribed by the attending physician. Since we did not self-medicate, the drug did not cause any side effects.
2. Secnidox was prescribed to my husband. We spent a long time deciding whether to take it or not. Our doctor convinced us of its effectiveness. We were very afraid of side effects, but my husband did not have any. My husband tolerated the drug well. Its effectiveness was proven by tests after taking it.
3. After going to camp, a child (14 years old) was diagnosed with giardiasis. We treated ourselves for a long time, but then decided to see a doctor. He recommended Secnidox to us. The drug helped immediately.
Shelf life
The medicine should not be stored for more than three years.
Attention!
To simplify the perception of information, this instruction for use of the drug "Secnidox" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.