Sodium fluoride

Sodium fluoride is used to prevent the development of caries.

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Indications Sodium fluoride

It is used as a preventive drug against caries, and in addition, it can be prescribed for the treatment of osteomalacia, osteoporosis, myeloma, diffuse metastasis in the area of bone tissue, and also for severe congenital bone fragility.

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Release form

The product is produced in tablet form, 250 pieces per bottle (1 such bottle per package).

Sodium Fluoride Orange Flavor

Sodium fluoride with orange flavor is prescribed to children. It is released in 10 tablets inside a blister plate. There are 3 such blisters in the package.

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Pharmacodynamics

Sodium Fluoride promotes the process of mineralization of teeth, and at the same time helps to form tooth enamel. The medicine has bactericidal properties and prevents the development of caries.

The use of the drug helps to reduce the resorption processes inside bone tissues. And when combined with calcium, as well as cholecalciferol, it promotes bone calcification.

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Pharmacokinetics

The active ingredient is well absorbed from the gastrointestinal tract. But it should be taken into account that calcium/magnesium salts, as well as aluminum, weaken the absorption of the drug. Peak plasma values are noted after 4 hours after oral administration of the drug.

Fluorides accumulate inside the body, mainly inside bones and teeth, as well as nails and hair.

Excretion occurs primarily in urine. In addition, the drug is excreted in saliva and feces.

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Dosing and administration

For children aged 2-6 years, the medicine in tablets of 1.1 mg is prescribed 1 per day. Older children are allowed to prescribe a single daily dose of 1 tablet of 2.2 mg or 2 tablets of 1.1 mg.

It is recommended to take the medicine before bed, after brushing your teeth. It is taken orally - you should hold the tablet in your mouth until it completely dissolves. This intake should last at least 250 days/year. It is advisable to take the medicine every year until the teenager reaches the age of 15.

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Use Sodium fluoride during pregnancy

The drug should not be prescribed to pregnant women.

Contraindications

Main contraindications:

• the presence of hypersensitivity to the components of the drug;
• aggravated ulcer inside the gastrointestinal tract;
• infants up to 2 years of age;
• lactation period;
• myxedema;
• kidney/liver failure;
• consumption of drinking water containing high levels of fluoride (more than 0.7 mg/ml).

The orange-flavored tablets contain aspartame, so they are prohibited for use in people with phenylketonuria. The resorbable tablets contain lactose, which is why they cannot be taken in cases of congenital galactose intolerance, as well as malabsorption syndrome or lactase deficiency.

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Side effects Sodium fluoride

The drug is generally tolerated by patients without complications. Occasionally, some side effects are observed: vomiting, fluorosis, diarrhea, and nausea. However, allergy symptoms may be observed - rashes, eosinophilia, and runny nose.

As a result of long-term use of the drug, osteosclerosis, visual impairment, headaches, arthritis, increased fatigue, and also ossification in the area of attachment of ligaments to tendons develop.

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Overdose

The lethal dose of the drug for an adult is a single dose of 5-10 g. However, quite severe consequences can be expected in the case of taking a dose of up to 1 g at a time.

Due to sodium fluoride poisoning, a high level of hydrofluoric acid is observed inside the body, which has an irritating effect on the gastrointestinal mucosa. Along with this, metabolic processes and electrolyte balance are disrupted. Hypocalcemia also develops.

The following adverse reactions may occur as a result of taking excessively high doses of the drug: dizziness, abdominal pain, and diarrhea with nausea. In addition, severe fatigue or excitability, increased temperature, tremor, respiratory failure, and respiratory arrest develop. A feeling of weakness or drowsiness, vomiting (normal and with blood), hypersalivation, tremors, stomach cramps, leg pain, loss of appetite, lacrimation, visual disturbances, and arthralgia may occur.

To eliminate intoxication, the patient's stomach should be washed using calcium chloride (1-5% solution) or calcium hydroxide (0.15% solution). In addition, the patient should be prescribed diuretics and saline laxatives. Aluminum hydroxide is used to reduce the degree of fluoride absorption. It is necessary to slowly administer a 10-20% solution of calcium gluconate intravenously. Along with this, the patient is prescribed hemodialysis and vitamins. Procedures aimed at eliminating the symptoms of disorders are also carried out.

In chronic poisoning, fluorosis is observed in the area of teeth and bones. There is an increase in the density of bone tissue, as well as calcification of ligaments with tendons. Such people experience darkening of the color of tooth enamel, limited mobility, and also deformation with pain in the area of joints.

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Interactions with other drugs

The drug is prohibited to be combined with any drugs, the components of which are calcium or aluminum hydroxide. If these drugs need to be taken, it should be done several hours before using Sodium fluoride.

The use of retinol or calciferol in combination with the drug may cause the development of ectopic calcification.

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Storage conditions

Sodium fluoride must be stored in a dark place, protected from moisture and access of small children. Temperature values should not exceed 25°C.

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Special instructions

Reviews

Sodium fluoride is often prescribed as a means of helping to form enamel on teeth, as well as promoting their mineralization. Reviews show that the drug has a very effective preventive effect against the development of caries, and also eliminates metastases of the diffuse type developing in bone tissue, as well as osteoporosis, plasmacytoma and osteomalacia. Among the advantages of the drug is also the fact that in most cases it is well tolerated by patients.

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Shelf life

Sodium fluoride can be used for 5 years from the date of manufacture of the drug.