Senorm

Senorm is a medical product that belongs to a group of neuroleptics, which has an antipsychotic effect.

Indications of the senorma

The Senorm can be used in the following cases:

• Schizophrenia;
• Psychoses;
• Alcoholic delirium;
• Manic-depressive syndrome;
• Hypomania;
• The Syndrome of Gilles de la Tourette;
• Disorders of behavioral reactions in children (aggression, excitability, hyperactivity);
• Indomitable vomiting.

Release form

On the pharmaceutical market, the Senorm exists in the form of:

• Tablets of one and a half or five grams, ten pieces per plate, one hundred pieces in a box;
•  R-ra for injections of five or fifty grams, one milliliter in an ampoule. The package contains five ampoules.

Pharmacodynamics

Senorm is a derivative of butyrofen. It refers to neuroleptics, exhibiting antipsychotic efficacy, and also by isolating postsynaptic pre-pharmacodynamic receptors in brain structures such as mesolimbic and mesocortical. In addition, the medication also exhibits calming and feigned efficacy. May contribute to the emergence of extrapyramidal disorders, but almost does not show cholinoblocking effectiveness.

The soothing effect is predetermined by the isolation of the alpha-adrenergic receptors of the brain, the contralateral effect is the isolation of the dopamine D2 receptors of the vomiting center, galactorrhea is the isolation of the dopamine nerve endings of the hypothalamus.

With prolonged use, there is a modification of the endocrine status: in the anterior part of the pituitary "grows" prolactin production and decreases - gonadotropic hormones.

Haloperidol decanoate with respect to Galloperidol has a longer lasting effect. Due to this, stable personality modifications are reduced, nonsense, visions, a reduction in the number of obsessions, and an increased interest in the outside world. It is highly effective in patients who are immune to neuroleptic medicines. Has a small activating effect.

In children with hyperactivity removes increased motor activity, behavioral disorders.

The therapeutic effect of the prolonged form of the drug lasts up to six weeks.

Pharmacokinetics

Bioaddism of the drug leaves 60-70%. If the Senorm is used inside, then its maximum density in the blood will reach its values within three to six hours. The Senorm is almost completely (90%) bound to serum proteins.

Density in erythrocytes relative to serum is one to twelve. In tissues, the density is higher than in the blood.

Metabolism occurs in the liver, the product of metabolism is not active in the pharmacological plan. Isolation occurs mainly with feces (60%) or kidney (40%). There is evidence of his penetration into the mother's milk. The half-life is about 24 hours (usually from 12 to 37 hours).

Dosing and administration

When ingested:

Take a pill for half an hour before eating. Treatment begins with 1.5 - 5 mg, which should be taken two to three times a day. Further, you can gradually increase the dosage to 15 mg per day until the greatest effectiveness is achieved. The daily maintenance dose is about 5 to 10 mg per day. Duration of treatment - two to three months.

Children from three to twelve years:

• with psychotic disorders from 0.05 to 0.15 mg per kilogram of body weight per day;
• with nonpsychotic behavior disorders and Tourette's syndrome: from 0.05 to 0.75 mg per kilogram of body weight per day.

The daily dose should be divided into two or three doses.

Injection (in / m or in / in):

The contents of the ampoule should be diluted with 10 - 15 ml of water.

The recommended dose is two to five milligrams two to three times a day. After achieving a stable effect, you can go to oral intake, increasing the daily dose by one and a half to two grams.

[1]

Use of the senorma during pregnancy

Use the medication during the gestational period is only possible if, if the likely effectiveness for a woman is much more dangerous for the child.

During breastfeeding, the medicine can not be used. If Senorma is needed in this period, breastfeeding should be stopped.

Contraindications

You can not use a medicine in such cases:

• Excessive sensitivity to any component of the drug;
• Oppression of the functionality of the central nervous system;
• Coma;
• Depressive state;
• Hysteria;
• Parkinsonism;
• Three years of age (in / m introduction).

Side effects of the senorma

When Senorm is appointed to the patient, it is worthwhile to warn him about such possible undesirable reactions:

• Extrapyramidal disorders;
• Headache;
• Increased drowsiness;
• Increase the number of heartbeats;
• Decrease in blood pressure;
• Anorexia;
• Stool disorders;
• Nausea and vomiting;
• Insufficiency of hepatic function;
• Anemia;
• Agranulocytosis;
• Gynecomastia;
• Inhibition of respiration (in / m use).

Overdose

If there is an overdose of the drug, it is likely to lead to the appearance of neuroleptic reactions. The main sign, which should pay close attention in this case will be - "growth" of body temperature. After all, it can talk about a substandard neuroleptic syndrome. If a severe overdose is likely to occur, various types of impairment of consciousness, including coma and the onset of seizures.

Therapy: the removal of neuroleptics, the use of correctors, intravenous diazepam, glucose, drugs that belong to the nootropic group, vit. Gr. B and C. And, in addition, the provision of therapy aimed at reducing the symptoms of overdose.

Interactions with other drugs

When used together with ethanol, medicines that refer to opioid analgesics, barbiturates - increase the inhibitory effect on the central nervous system;

Increases the effectiveness of pressure-lowering medications and m-cholinoblockers;

Senorm in a joint use with tricyclic drugs against depression and MAO inhibitors, inhibits their metabolism. At the same time, there is a simultaneous simultaneous increase in their calming effect and toxicity.

Joint use with Bupropion - there is a decrease in the epileptic threshold and the probability of epileptic seizures increases;

With anticonvulsant medications - Ctor reduces the effectiveness of these drugs;

With a single use of the Centor with Dopamine, Phenyefrin, Ephedrine and Epinephrine - there is a decrease in the vasoconstrictive effect of the latter;

Reduces the effect of medications that are directed at fighting against Parkinsonism.

Reduces or increases the effect of anticoagulants;

If you use Sentor with Bromocriptine at a time, you may need to adjust the dosage of the latter. This is due to the fact that its effect with this use is reduced.

Psychiatric disorders may develop if you simultaneously use Senorm and Methyldopa (for example, disorientation in space may occur, a decrease in the function of thinking);

Haloperidol reduces the stimulating effect on the psyche of amphetamines, and they reduce its antipsychotic effect;

Antihistamines and anticholinergic medicines increase the m-anticholinergic action of Senorm and reduce its antipsychotic effect;

If, together with Galperidol, a long period of time to use carbamazapine - there will be a decrease in its density in the plasma;

The likelihood of encephalopathy increases and etrapiramid symptoms will increase, with the interaction of haloperidol with Li + medicines.

Extrapyramidal reactions may also occur in the interaction of the Senorm and Fluoxetine;

Strong tea or coffee - will reduce the action of the Senorm.

[2], [3]

Storage conditions

The Senorm should be stored in an impenetrable spot for sun rays, observing the temperature regime at 25 ° C. The place must be closed to children.

[4]

Shelf life

Shelf life depends on the type of release. So:

• rr for the / m input to be stored - two years;
• rp for I / O and / m input - three years;
• pills - five years

Reviews

The drug can be used only for the purpose of the attending physician, who, having carefully studied the patient's medical history and having weighed all possible risks, will be able to prescribe the most effective treatment regimen. About occurrence of all possible undesirable reactions, it is necessary also to inform the doctor, it will help him to correct treatment and as soon as possible to reduce their manifestation.