Fexofast

The fexofast is a medical remedy for allergic reactions, which can be used in the treatment of people engaged in activities that require increased attention. Because of this drug they do not have drowsiness, as well as addiction.

Indications of the fexofast

The fexophastus can be used in such cases as:

• Coryza of an allergic origin, which manifests itself in a certain season
• Hives of a chronic nature.

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Release form

The fexofast is available in tablets, ten pieces per plate. Each pill contains 180 or 120 mg of the active substance. In the packaging of cardboard can be ten or thirty such tablets.

Pharmacodynamics

The drug exhibits anti-allergic, antihistamine activity. Relate to non-calming insulators of H1-histamine nerve endings. It is a product of the metabolism of Terdenafin.

Antihistamine action is manifested as early as an hour after ingestion, reaching its highest values after six hours and remaining active throughout the day.

There is no evidence of the occurrence of tolerance during repeated use.

Also, it does not reveal cholinolytic, adrenolytic and soothing activity. In addition, if it does not exceed the recommended dosage, it does not contribute to the appearance of any changes in the calcium or potassium passages and the QT interval.

Pharmacokinetics

After the Fexofast tablet is taken, adsorption is quickly carried out from the digestive tract. At the same maximum values, the density of the drug reaches even after 1 to 3 hours. So, in a dose of 180 mg, the highest density is 494 ng / ml, 120 mg - 427 ng / ml.

The drug establishes a link with plasma proteins by 60 to 70 percent (mainly with albumin and alpha1-glycoprotein).

There is no data on the penetration of fexophastus through the blood-brain septum.

After repeated use, the elimination half-life is 14.4 hours. In this case, it should be borne in mind that in patients with moderate and severe form of kidney failure, as well as those undergoing hemodialysis, this temporary interval will increase by 59, 72 and 31%, respectively.

For five percent of the dose, the metabolism passes beyond the liver.

Excretion occurs: bile (eighty percent) and kidneys (eleven percent).

Dosing and administration

The fexofast should be taken orally. The adult population and children over the age of twelve with allergic rhinitis - 120 mg of medication once a day.

In the case of a pathology such as chronic hives, 180 mg of fexofast is also administered once a day.

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Use of the fexofast during pregnancy

Gestation period

Sufficient information about the use of fexofast in this period there. Tests conducted on animals show that this medication, directly or indirectly, does not affect the bearing of the child, fetal or postnatal development and labor activity. Therefore, in the gestational period, you can use Faxovast, but only if the effect for the mother exceeds the risk for the child.

Lactation period

Since there are data on the penetration of fexofast into breast milk, it can not be taken while the baby is breastfed.

Contraindications

Hypersensitivity, pregnancy, lactation, children's age (up to twelve years).

Side effects of the fexofast

Undesirable effects of the drug:

• The patient who takes fexofast should know that he or she may experience the following unwanted reactions:
• Headache;
• Fatigue;
• Nausea;
• Dizziness;
• Sleep disorders;
• Rashes on the skin;
• Hives;
• Cutaneous overgrazing;
• Dyspnea;
• Edema of the Quincke.

Overdose

With excessive use of fexofast, the patient may experience dizziness and dryness in the oral cavity.

In this case, it is necessary to carry out a set of standard measures for removal from the gastrointestinal tract of a nonabsorbed medical device. In addition, symptomatic and supportive treatment will also be required. The procedure of hemodialysis in this case will not be effective.

Interactions with other drugs

With the simultaneous use of fexofast with certain medications, it is worth bearing in mind that:

1. With erythromycin or ketoconazole, the density of fexofenadine in serum increases significantly (two to three times).
2. If you use an antacid that contains Mg or Al, fifteen minutes before the fexofast, there will be a decrease in the bioavailability of the drug against allergies. Therefore, between using these drugs should take at least two hours.
3. With omeprazole and drugs, the metabolism that passes in the liver - fexofast does not come into interaction.

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Storage conditions

The fexofast must be stored in the original packaging, observing the temperature regime at 25 ° C, outside of the children's access.

Shelf life

With all the necessary measures for the proper storage of the medicine, it can be used for three years.

Reviews

There are a lot of comments about the fexophastus of people who take it in connection with an allergic rhinitis or urticaria. And almost all of them are about how effective this drug is. It was thanks to this that the fexophastus took his niche among a great many different means from allergies.

But, of course, it should be borne in mind that this drug is a medicinal product, so before starting to use it, always consult your doctor.