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Senadix
Last reviewed: 23.04.2024
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Senadex is a laxative drug of contact type. Included in the category of hay glycosides.
Indications of the senadex
It is used for constipation, which occurs due to intestinal atony, which has a different origin. In addition, it is in the process of preparing for the X-ray procedures.
Release form
The release is made in tablets, in quantities of 6 or 12 pieces inside a blister pack. The package contains 1 or 2, as well as 5 or 10 blister plates.
Also, tablets can be contained in containers - 30 or 50 pieces each. In the box there is 1 such container.
Pharmacodynamics
A medicine with a laxative effect, which has a vegetative nature. Senna is included in the category of drugs that stimulate the laxative effect (in mild form). It contains anthrinoids.
The laxative effect is exerted by 1,8-dihydroxyanthracene derivatives. This effect of sennosides (more precisely, their active metabolite product - reynanthron) within the large intestine is determined mainly by the effect on its functional mobility: stationary slows down, and propulsive contractions are simultaneously stimulated. This leads to faster passage of food inside the gastrointestinal tract, which reduces the duration of contact between the chyme and the walls of the intestine, and also reduces the resorption of the fluid.
Along with this, stimulation of the activity of hydrochloric acid release also leads to the secretion of water with electrolytes.
Pharmacokinetics
Glycoside-synthesized cenozides (the so-called caciotides) is a prodrug. They do not lend themselves to splitting and absorption inside the upper part of the digestive tract. These elements are split by the bacterial enzymes inside the large intestine, transforming into a reynanthron.
Reynanthron is a metabolic product that exerts a laxative effect. He has extremely low systemic bioavailability. In animal tests, less than 5% of sennoside and rhein derivatives (in the form of substances subjected to oxidation, and in addition partial conjugation) were excreted together with urine.
A significant part of reynanthron (more than 90%) falls into the feces, and there it is firmly synthesized with intestinal contents. Excretion takes place in the form of compounds of the polymer type.
A small part of the active metabolic products (eg, rhein) passes into the mother's milk. Passage of rhein through the placental barrier during the tests on animals occurred in minimal quantities.
Dosing and administration
Dose sizes are determined individually. For adolescents from 12 years and adults, doses are 2 tablets, with a dose of 1-2 times / day. For a day you can take no more than 4 tablets of medicine.
Elderly people need to start therapy with a dosage of 1 tablet.
It is required to use the minimum size on the size, rendering restoring effect on job of a stomach.
The medication is taken only by short-term courses.
It is forbidden to use laxatives during more than 7 days if you do not have a doctor's appointment.
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Use of the senadex during pregnancy
It is forbidden to appoint Senadix to pregnant women, as well as to nursing women.
Contraindications
The main contraindications:
- the presence of hypersensitivity relative to the elements of the drug;
- inflammations affecting the GIT area in acute form (colitis (and its ulcerative form), as well as regional enteritis);
- presence of vomiting or nausea;
- diseases in the digestive system that were not previously diagnosed and can develop due to intestinal pathologies in acute form or surgical operations (such as appendicitis and diverticulitis, and in addition peritonitis and frequent diarrhea);
- blockage of the intestine (sometimes in paralytic form);
- constipation of a spastic nature;
- strangulated hernia;
- bleeding inside the gastrointestinal tract or uterus;
- cystitis;
- pain sensations in the epigastrium, having an indeterminate etiology;
- painful sensations of a spastic nature;
- hepatic lesions of an organic nature;
- disorders of water-electrolyte balance in severe degree (eg, hypokalemia);
- bleeding in the rectal area;
- children under 12 years of age.
Side effects of the senadex
The main contraindications:
- the presence of hypersensitivity relative to the elements of the drug;
- inflammations affecting the GIT area in acute form (colitis (and its ulcerative form), as well as regional enteritis);
- presence of vomiting or nausea;
- diseases in the digestive system that were not previously diagnosed and can develop due to intestinal pathologies in acute form or surgical operations (such as appendicitis and diverticulitis, and in addition peritonitis and frequent diarrhea);
- blockage of the intestine (sometimes in paralytic form);
- constipation of a spastic nature;
- strangulated hernia;
- bleeding inside the gastrointestinal tract or uterus;
- cystitis;
- pain sensations in the epigastrium, having an indeterminate etiology;
- painful sensations of a spastic nature;
- hepatic lesions of an organic nature;
- disorders of water-electrolyte balance in severe degree (eg, hypokalemia);
- bleeding in the rectal area;
- children under 12 years of age.
Overdose
Due to intoxication, diarrhea, intestinal colic, and irritation in the gastrointestinal tract can occur. In addition, the balance of water and electrolytes may be disturbed, epigastric pain, nausea, convulsions, intestinal disorders, metabolic acidosis, and collapse of the vascular nature may develop.
To eliminate the disorders, it is necessary to perform gastric lavage and symptomatic therapy. If there is a risk of diarrhea with complications, the patient should be prescribed to drink as much fluids as possible.
Interactions with other drugs
Long-term use or use of Senadex at high dosages potentiates the effects of antiarrhythmic drugs and SG - due to a reduction in potassium levels within the body. The drug also disrupts the absorption of tetracyclines.
Combined use with diuretics of the thiazide type, and in addition with liquorice and glucocorticosteroids increases the likelihood of hypokalemia.
It is forbidden to use drugs in the period of 2 hours before or after using other drugs, because this can lead to a decrease in absorption and therapeutic effects of the latter.
Weaken the effectiveness of drugs that are slowly absorbed through the digestive tract.
Storage conditions
The Senadex should be kept in a place inaccessible to children. The temperature conditions are not higher than 25 ° C.
Shelf life
Senadec is allowed to be used for 3 years from the date of release of the medicinal product.
Attention!
To simplify the perception of information, this instruction for use of the drug "Senadix" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.