Sehydrin

Sehydrin is a drug used to treat malignant neoplasms. Consider the main properties of the drug, its dosage and therapeutic effect.

Apply antitumor agent can only be under the supervision of a doctor who has experience in using such drugs. With special care, the drug is prescribed to patients with severe impairment of liver and kidney function. In this case, Segidrin is allowed for patients with jaundice with metastases in tagging.

During therapy, it is necessary to exclude the use of drugs and beverages, which include ethanol. Under the ban fall products with tyramine. Because the drug is low in toxicity, it can be used for patients with cytopenia that occurs with chemotherapy or radiotherapy.

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Indications of the sehydrina

Sehydrin has an antitumor therapeutic effect. The main indications for its use:

• Progressive inoperable forms of malignant neoplasms.
• Relapses and metastasis of malignant tumors.
• Lungs' cancer.
• Neuroblastoma.
• Cancer of the stomach, pancreas and other organs of the digestive system.
• Oncology of mammary glands.
• Astrocytoma, glioblastoma and other primary brain tumors.
• Fibrosarcoma and soft tissue sarcoma.
• Lymphosarcoma.
• Cancer of the larynx.
• Lymphogranulomatosis.
• Cancer of the endometrium and cervix.
• Desmoid cancer.

The drug can be used for the symptomatic treatment of disseminated and locally advanced forms of malignant tumors. Sehydrin reduces the severity of the pain syndrome, eliminates respiratory failure, increased weakness, fever. Improves appetite and improves motor activity.

Release form

Sehydrin has a tablet form of release. The tablets are covered with an enteric-coated shell, a red-brown color. One capsule contains the active ingredient - hydrazine sulfate 60 mg. Auxiliary substances are: polymethacrylate, magnesium stearate, titanium dioxide, dimethicone and polyethylene glycol, disubstituted calcium phosphate and others. Produced in blisters of 10 pieces and 50 pieces in polymer jars.

Pharmacodynamics

The active substance of the drug suppresses the growth of tumors. Pharmacodynamics indicates the effect of hydrazine sulfate on certain biochemical indices. The drug reduces the permeability of cell membranes and biomembranes of subcellular structures, inhibits monoamine oxidase activity and acts as an inhibitor of the metabolism of xenobiotics. Antitumor effect is particularly active in severe stages of cancer. The medication does not have mielodepressive and other side effects. 

Pharmacokinetics

After oral administration, the maximum concentration of the drug in the blood plasma comes after 2 hours. Pharmacokinetics indicates the accumulation and increase of 3-5 times the active substance in the liver, kidneys and lungs. This happens when using tablets for a long period of time.

Removal of the components of the drug from intact organs affected by the tumor process and healthy occurs on the 4th day of treatment. Excretion is carried out with urine and is about 50% of the dose taken, partly in the acetylated form. The medicine is not oxidized in the body.

Dosing and administration

From the stage and severity of the course of malignant disease depends on the method of application and dose of Sehydrin. The drug is administered orally 1-2 hours before meals or 1-2 hours after it or taking other medications. Recommended dosage - 1 tablet 3 times a day. The course dose of 100 tablets. If necessary, the dosage can be increased to 2 tablets per day. Repeat the course of therapy can be done after 14 days. The number of courses is not limited, subject to a time interval of 1-3 weeks.

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Use of the sehydrina during pregnancy

Segidrin is contraindicated in pregnancy and lactation. This is associated with a high risk of developing pathologies in the fetus and disturbing the course of gestation. Medication is not prescribed for the treatment of children. Use with extreme caution for patients with severe renal and hepatic impairment.

Contraindications

Sehydrin has such contraindications for use:

• Individual intolerance of the active ingredient and other constituents of the drug.
• Pregnancy and breastfeeding.
• Children's age of patients.

Tablets are forbidden to be taken simultaneously with barbiturates and all kinds of alcohol.

Side effects of the sehydrina

During treatment with Sehydrin, development of undesirable reactions is possible. Side effects are most often manifested dyspeptic symptoms (nausea, vomiting, heartburn, belching), which go away after dosage reduction. General excitement and various sleep disorders are also possible.

To eliminate pronounced dyspeptic phenomena, the use of anti-inflammatory drugs, antiemetics and antispasmodics is shown. With neurotoxic effects, it is necessary to take pyridoxine hydrochloride, thiamine chloride or multivitamin preparations intravenously / orally.

Overdose

If the dose prescribed by the doctor is not observed, various pathological symptoms may appear. Overdose manifests dyspeptic disorders (nausea, vomiting, stool disorders), which themselves disappear after lowering the dosage or temporarily stopping treatment for 2-3 days.

Interactions with other drugs

Since Sehydrin refers to antitumour agents, all its interactions with other drugs should be controlled by the attending physician. The drug is contraindicated to be taken simultaneously with tranquilizers, barbiturates, ethanol or antipsychotic drugs, as this leads to a sharp increase in the toxicity of Sehydrin. The use of the drug in front of other antitumour agents significantly increases their effectiveness, except for cyclophosphamide.

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Storage conditions

Tablets should be stored in their original packaging, closed from sunlight, moisture and out of reach of children. According to the storage conditions, the temperature should be within 15-25 ° C. Failure to comply with these recommendations leads to premature loss of medicinal properties of the medicament.

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Shelf life

Sehydrin is allowed to be used within 36 months from the date of its production. The expiration date of this antitumor agent is indicated on the package. At its expiration, the drug must be disposed of.