Sedal-M

Sedal-m is a painkiller with anti-inflammatory properties. Let's consider the indications for use of the drug, dosage, side effects.

Sedal-m is a complex drug with analgesic, antipyretic and sedative properties. It belongs to the pharmacotherapeutic category of non-narcotic analgesic, antipyretic NSAIDs. The analgesic-antipyretic contains five components (metamizole sodium, paracetamol, codeine, phenobarbital and caffeine), which provide its therapeutic effect.

Indications Sedala-M

Sedal-m is indicated for use to relieve pain in patients with severe headaches and muscle pain, migraines, neuritis, neuralgia. It helps with algomenorrhea with painful sensations that developed due to injuries, burns and surgeries. It is used as an analgesic and antipyretic agent for patients with inflammatory lesions of the upper respiratory tract of various etiologies.

Release form

Sedal-m is available in tablet form. Tablets in blister packs of 10 pieces each, one pack of 1 or 2 blister packs. Each tablet contains the following active ingredients: paracetamol 300 mg, metamizole sodium 150 mg, caffeine 50 mg, phenobarbital 15 mg, codeine phosphate 10 mg and auxiliary components.

Pharmacodynamics

Since the drug has a combined composition, the pharmacodynamics is represented by the interaction of all active components. The drug has an antipyretic, analgesic, anti-inflammatory and sedative effect. These properties are provided by paracetamol and metamizole (analgin), which are non-narcotic analgesics. By inhibiting cyclooxygenase in the central nervous system, they destroy the synthesis of prostaglandins.

Low doses of phenobarbital provide a sedative effect. Codeine is an opioid analgesic, has pain-relieving, analgesic and antitussive properties. Caffeine stimulates the central nervous system, helps to increase efficiency, improves cerebral circulation and cerebral vascular tone, and helps to concentrate. This substance enhances the properties of non-steroidal anti-inflammatory drugs. Caffeine dilates blood vessels in the brain, reduces headaches. Low doses of phenobarbital have a sedative effect and potentiate the effect of the analgesic components of the drug.

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Pharmacokinetics

After oral administration, individual combinations of Sedal-m are rapidly and completely absorbed from the gastrointestinal tract. Pharmacokinetics of the drug indicate its rapid metabolization. It is excreted by the kidneys with urine. The half-life of all components of the drug is different: paracetamol 1.5-3 hours, metamizole 1-4 hours, caffeine 3-6 hours, codeine 3-4 hours.

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Dosing and administration

Since Sedal-m is a prescription drug, the method of administration and dosage depend on the doctor's prescription. The drug is taken orally. To minimize the risk of developing side effects from the digestive tract, the tablets should be taken after meals with water.

As a rule, patients are prescribed 1 tablet 3 times a day. If necessary, the dosage can be increased to 2 tablets 2-3 times a day. The maximum permissible daily dosage is 7 tablets per day. If the drug is used for a long period of time, it is necessary to monitor the blood picture, liver and kidney function.

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Use Sedala-M during pregnancy

Sedal-m is not recommended for use during pregnancy and breastfeeding. This is due to potential risks to the fetus. The drug is prescribed when the expected benefit to the mother is much higher than the possible consequences for the unborn child.

Contraindications

Sedal-m is contraindicated for use in case of individual intolerance to its active components and drugs from the NSAID group. The drug is not prescribed for patients with severe renal and hepatic dysfunction, hemorrhagic diathesis, anemia, glucose-6-phosphate dehydrogenase deficiency and bronchial asthma.

The tablets are contraindicated for pain relief in patients under 14 years of age. They are not prescribed for pregnant women and women who are breastfeeding. They are used with special caution to treat patients with gastric ulcer and duodenal ulcer.

Side effects Sedala-M

As a rule, Sedal-m is well tolerated by patients. Side effects develop rarely, and, as a rule, in patients with hypersensitivity to the components of the drug or during long-term therapy.

Side effects are manifested by the following symptoms:

• Impaired coordination of movements and orientation in space.
• Dizziness and headaches.
• Sleep and wakefulness disturbances.
• Tremor of the limbs.
• Increased fatigue and anxiety.
• Tachycardia.
• Lowering blood pressure.
• Hemolytic anemia.
• Discomfort and pain in the epigastric region.
• Increased dryness of the oral mucosa.
• Nausea, vomiting, diarrhea.
• Skin allergic reactions.

To eliminate the above symptoms, you must stop taking the drug, undergo symptomatic therapy and consult a doctor.

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Overdose

The use of increased doses of Sedal-m leads to overdose. It is manifested by the development of increased drowsiness, headaches and dizziness, nausea, asthenia, dryness of the oral mucosa, respiratory depression, and the development of bradycardia.

There is no specific antidote, so gastric lavage and enterosorbent intake are indicated. Forced diuresis is indicated to normalize the level of active blood components. Symptomatic therapy is performed to eliminate other signs of intoxication.

Interactions with other drugs

When interacting with other drugs, Sedal-m may increase the risk of developing adverse reactions. It is also possible to change the pharmacokinetic properties of oral anticoagulants, cortisone derivatives, ethyl alcohol, non-narcotic analgesics, neuroleptics. When using Sedal-m in combination with other medications, it is necessary to take into account the interaction of each individual active substance of the drug with a particular drug.

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Storage conditions

The tablets should be kept in the original packaging, protected from sunlight, moisture and out of the reach of children. Storage conditions imply maintaining a temperature regime of no more than 25 °C.

Shelf life

Sedal-m is available from pharmacies only with a doctor's prescription. The expiration date of the drug is 36 months from the date of its production (indicated on the packaging and blister with tablets). Expired medication is prohibited.