, medical expert
Last reviewed: 11.04.2020

All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.

We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.

If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.

Naproff is a medicine from the NSAID group.


Indications of the naproff

It is shown in such cases:

  • dental or headaches;
  • migraine attacks;
  • pain during menstruation;
  • pain in the joints, muscles, and spine (problems with the functioning of the OA);
  • pains that appear after injury (due to overexertion, various bruises or sprain);
  • pain after surgical operations (orthopedic, traumatological, dental, and gynecological procedures);
  • rheumatic pathologies (rheumatoid arthritis, osteoarthritis, as well as gout and Bekhterev's disease).

Release form

Produced in tablets, 10 pieces per 1 blister. Inside a single pack contains 1-2 blister plates.


Naproxen is an NSAID, a methylacetic acid derivative. The substance has strong analgesic, anti-inflammatory and antipyretic properties.

The active component acts by slowing down the process of moving leukocytes, as well as weakening of lysosomal activity and conductors of inflammation. The drug is a potent inhibitor of lipoxygenase, and in addition, a blockade of the binding processes of arachidonic acid. Together with this, it slows down the action of COX-1 elements, as well as COX-2 entering arachidonic acid, as a result of which the process of binding of intermediate products of PG is inhibited. The substance slows down and glues the platelets.

Naproxen sodium is not an opioid analgesic, so it has no effect on the CNS.


When taken orally, the medicine is quickly and almost completely absorbed from the digestive tract. The bioavailability level reaches 95%. The half-life of the active ingredient is 12-17 hours.

Eating does not affect the performance of the substance in the blood. The peak value is noted after 1-2 hours.

The distribution volume is 0.16 l / kg. After consumption in medicinal concentrations, naproxen is synthesized with the protein by 99%.

Metabolism of the active substance is carried out in the liver, with the formation of the element 6-O-desmethyl-naproxen. Further, both these components participate in the conjugation processes.

The purification index of naproxen is 0.13 ml / minute / kg. About 95% of the substance is excreted unchanged together with the urine (and in addition in the form of 6-O-desmethyl-naproxen and conjugates of both constituent elements).

Use of the naproff during pregnancy

The medicine can not be taken by pregnant women, as well as during breastfeeding.


Among the contraindications:

  • intolerance of naproxen or other constituent elements of the drug;
  • presence of urticaria or bronchial asthma and other allergic manifestations that arise from the use of salicylates and other NSAIDs;
  • exacerbation of an ulcer of duodenum a gut or a gastric ulcer (or their relapse), and also bleedings in GASTROINTESTINAL TRACT;
  • children's age is less than 16 years;
  • disorders in the work of the kidneys (level of QC <30 ml / minute) or liver in severe form, and in addition, heart failure.

Side effects of the naproff

Due to the use of the drug (often in excess doses), side effects may develop:

  • organs of the digestive system: most often develop constipation, nausea, abdominal pain, diarrhea, dyspepsia and stomatitis. In rare cases, bleeding occurs in the gastrointestinal tract or gastric perforation, and in addition, melena, hematemesis and vomiting;
  • liver: the liver enzymes sometimes increase or jaundice develops;
  • organs of the National Assembly: often develop dizziness, vertigo, drowsiness and headaches. Occasionally, insomnia, pain or weakness in the muscles, sleep disorder, depression, nausea and concentration problems occur;
  • subcutaneous layers and skin: mostly there are rashes, itching, bruises, developing hyperhidrosis or purpura. More rarely, alopecia starts or dermatitis of a photosensitive type develops;
  • auditory organs: mostly there are noises in the ears, and occasionally hearing disorders can develop;
  • visual organs: often develop disorders of visual function;
  • organs of the cardiovascular system: mainly dyspnea, palpitations and swelling occur. Occasionally a congestive form of heart failure is observed;
  • systemic frustration: there is often a feeling of thirst. In some cases, the state of fever develops, allergy symptoms appear, the menstrual cycle is disrupted;
  • organs of the system of urination: occasionally develops hematuria, kidney deficiency, glomerulonephritis, tubulointerstitial nephritis, and besides nephrotic syndrome and necrotic papillitis;
  • lymph and hematopoietic system: occasionally there is thrombocyto-, granulocyto- or leukopenia and eosinophilia;
  • organs of the respiratory system: in some cases eosinophilic pneumonia is noted.

Side effects, the relationship of which with the medicine could not be clarified:

  • lymph and hematopoietic system: development of anemia (hemolytic or aplastic form);
  • organs of the National Assembly: cognitive impairment or aseptic form of meningitis;
  • cutaneous and subcutaneous layers: erythema multiforme, Lyell or Stevens-Johnson syndromes, photophobia (similar to hematoporphyria in chronic form), urticaria, and hereditary pemphigus;
  • organs of the digestive tract: development of the ulcerative form of stomatitis;
  • organs of the CCC: the appearance of vasculitis;
  • systemic disorders: hypo- or hyperglycemia, Quincke edema.

In case of severe adverse reactions, it is necessary to cancel the use of the medicine.

trusted-source[2], [3]

Dosing and administration

Tablets should be swallowed completely, washed down with water.

The course of treatment begins with the most effective dosages of drugs for the period of the shortest possible duration of a period of time. Doses can be adjusted in accordance with the occurrence of negative manifestations and drug effects.

The size of the standard dosage to get rid of pain is 550-1100 mg. At the initial stage, it is required to drink 1 tablet (550 mg), and then the portion is allowed to be increased by parts of 275 mg (with a limit of 1100 mg per day). Further, in the period of therapy, it is required to drink 275 mg of medication 3-4 times per day. The intervals between receptions are usually approximately 6-8 hours.

Persons who tolerate small doses of drugs and who do not have a history of gastrointestinal pathology are allowed to increase the daily dose to 1375 mg during too severe pain (severe forms of ODA disorders, pain due to migraine, acute gouty attacks, and dysmenorrhea).

When the first symptoms of a migraine attack occur, you need to drink 825 mg of medication (this is equal to 3 tablets of size 275 mg or first tablet of 550 mg and 1st tablet with a volume of 275 mg). Then, if necessary, it is allowed to drink an additional 275-550 mg, but this should be done at least 30 minutes after the use of the initial portion. For a day, you can use no more than 5 tablets (or 1375 mg).

To remove spasms from pains that occur during menstruation, and in addition to pain after the procedure of installing a spiral inside the uterus, you need to drink 550 mg of the drug. If necessary, you can drink another 275 mg. The initial day of the course can take up to 1375 mg of the drug, and in the future - no more than 1100 mg.

During the period of acute gout, you must first drink 825 mg of LS, and then take it in parts at a rate of 275 mg at intervals of 8 hours until the attack ceases. Thus it is impossible to exceed the maximum daily dose, which is equal to 1375 mg.

When eliminating rheumatic pathologies (osteoarthritis, Bechterew's disease or rheumatoid arthritis), the size of the first daily dose taken is 550-1100 mg (two methods are morning and evening). Persons with severe night pain or mild morning mobility, as well as those who switch from other NSAIDs (in large doses) to the medicine Naproff, and people with arthrosis (in which the main symptom is pain), the initial daily dose will be 825-1375 mg. Continue the therapeutic course of daily proportions of 550-1100 mg, which are often divided into 2 uses. Morning and evening doses can not be the same size - you need to adjust them in relation to the prevailing manifestations of the disease (nocturnal pains / weak morning mobility). Individuals may miss a one-time daily dose (in the morning or in the evening).

The therapeutic course needs to be reviewed after the same time intervals. In the absence of a positive effect, it is necessary to cancel the medicine.

trusted-source[4], [5]


As a result of intentional or unintentional overdose, it is possible to develop vomiting, abdominal pain, nausea, ear ringing, and in addition dizziness, drowsiness, or irritability. When heavy intoxication occurs melena, vomiting of blood, but in addition, a disorder of respiratory function or consciousness, kidney failure and convulsions.

To get rid of the symptoms, requires gastric lavage, the use of activated carbon (at a rate of 0.5 g / kg), and in addition misoprostol with antacid drugs and inhibitors of conductors-H2 and proton pump. Symptomatic therapy is also performed.

Interactions with other drugs

The component naproxen is able to weaken the adhesion of platelets, which is why the bleeding period is prolonged. This feature should be taken into account during the definition of bleeding time, as well as in the case of combination with anticoagulants.

Since the drug is synthesized in large quantities with the plasma protein, it is required to combine it with caution with the derivatives of sulfonylurea, as well as hydantoin.

With simultaneous application with furosemide, its natriuretic effect decreases. When combined with antihypertensive drugs, their effectiveness is weakened. Also, the drug can increase the plasma level of lithium.

Naproff reduces the tubular excretion of methotrexate, so that the toxic properties of the latter with a combination of these drugs can increase.

The combination with probenecid extends biological half-life and increases the plasma parameters of naproxen.

When combined with cyclosporine, it is possible to increase the likelihood of developing functional renal disorders.

Like other NSAIDs, this drug can increase the likelihood of developing kidney disorders when combined with ACE inhibitors.

In vitro tests have demonstrated that the combination of a drug with zidovudine increases the plasma values of the latter.

When combined with antacid drugs that contain aluminum and magnesium, as well as sodium bicarbonate, the absorption index of the active substance of the drug decreases.

Combination of Naproff with prednisolone can greatly increase the plasma level of the latter.

trusted-source[6], [7], [8]

Storage conditions

Contain tablets are required in a place where moisture does not penetrate, and also inaccessible to small children. The temperature level is 25 ° C.

Shelf life

Naproff can be used during the 3 years since the release of the medicine.

trusted-source[9], [10]


To simplify the perception of information, this instruction for use of the drug "Naproff" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

You are reporting a typo in the following text:
Simply click the "Send typo report" button to complete the report. You can also include a comment.