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Sebivo
Sebivo is an antiviral drug. Consider the main indications for its use, pharmacotherapeutic properties, dosage, side effects.
The drug is active against hepatitis B virus. This viral disease is characterized by damage to the liver tissue and a pronounced inflammatory process. The disease is transmitted by harmful microorganisms from person to person. Hepatitis B has an acute course that, when properly treated, ends in recovery. Otherwise, the pathology passes into a chronic form and can lead to a lethal outcome.
Release form
Sebivo has a tablet form of release. The tablets are covered with an enteric coating, have a white color and an oval shape. Each capsule contains 600 mg of the active ingredient - telbivudine. Excipients are: microcrystalline cellulose, povidone, sodium carboxymethyl starch, magnesium stearate, silicon dioxide colloidal anhydrous. The drug is available in cardboard packages of 14 pieces in one blister.
Pharmacodynamics
The active substance of the drug Sebivo is telbivudine. Pharmacodynamics of the drug is based on the activity of this component in relation to the infectious agent. Telbivudine is a synthetic analogue of thymidine nucleoside. It acts on the DNA polymerase of hepatitis B virus. It is actively phosphorylated by cellular kinases, reaching an active triphosphate form with an intracellular half-life of about 14 hours.
Pharmacokinetics
The process of absorption, distribution, metabolism and excretion is a pharmacokinetics. After receiving a single dose of telbivudine in 600 mg, complete absorption is observed. The maximum concentration in the blood plasma is achieved two hours after admission. The constant concentration in serum develops during 5-7 days of regular use of tablets. Absorption and systemic action do not depend on food intake. Binding to blood plasma proteins is low. Distribution of tissues and organs is equal.
After reaching the maximum concentration, the half-life begins, which takes 40-49 hours. Telbivudine is excreted unchanged in the urine. About 42% of a single dose is excreted within 7 days.
Contraindications
Sebivo has such contraindications to the application:
- The age of patients younger than 18 years.
- Pregnancy and lactation.
- Individual intolerance of the components of the drug.
With special care, the drug is prescribed for patients with impaired renal and hepatic function, after liver transplantation, for people over 65 years of age.
Side effects of the sebivo
If the application of Sebivo is violated, it is possible to develop various adverse reactions. Side effects are most often manifested by such symptoms:
- Headaches and dizziness.
- Paresthesia.
- Cough and respiratory failure.
- Nausea, abdominal pain, stool disorders.
- Skin allergic reactions.
- Muscle spasms and pain in the side.
- Increased fatigue.
In some patients after the end of the drug, there were severe cases of exacerbation of hepatitis B.
Dosing and administration
For the treatment and prevention of chronic hepatitis B, 600 mg Sebivo is recommended. The method of application and dose depend on the severity of the course of the pathological process, therefore they are appointed by the attending physician, for each patient individually. If the medicine is prescribed to patients who are on hemodialysis, then the tablets are taken after the procedure. The course of treatment depends on the results of therapy in the early days of it.
Interactions with other drugs
Very often in the treatment of chronic hepatitis B use a set of different medications. Interactions with other drugs should be strictly controlled. Sebivo is excreted mainly by the kidneys, so when it is concurrently taken with drugs that affect kidney function, an increase in the concentration of telbivudine is possible.
Pharmacokinetic properties of the drug do not change when used with Lamivudine, Dipivoxil, Peginterferon-alpha 2a or Cyclosporin. Sebivo is not recommended to be used simultaneously with interferon alpha. When monotherapy with nucleoside / nucleotide analogues of the drug or when combined with antiretroviral agents, it is possible to develop severe hepatomegaly with steatosis or lactic acidosis.
Medical expert editor
Portnov Alexey Alexandrovich
Education: Kiev National Medical University. A.A. Bogomolets, Specialty - "General Medicine"
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Attention!
To simplify the perception of information, this instruction for use of the drug "Sebivo" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.