Salmodil

Salmodyl is a drug from the category of medicines with anti-asthmatic properties. This syrup, due to the combination of two main active ingredients in an optimal ratio - bromhexine with salbutamol, combines both the best characteristics of its expectorant action and produces a pronounced bronchodilator effect.

The first of its main pharmacologically active components is bromhexine, a mucolytic agent that has demonstrated its effectiveness in the treatment of respiratory disorders caused by the release of a significant amount of mucus and its excessively viscous consistency.

Salbutamol, which is a sympathomimetic synthetic amine, produces a stimulating effect on beta-adrenergic receptors, and promotes better expectoration, activates mucus production processes and acts in the bronchi as a stimulator of the functioning of their ciliated epithelium. Salbutamol tends to produce a stimulating effect to a greater extent on the muscle tissue of the bronchi, uterine and smooth vascular muscles, rather than on cardiac beta-receptors.

Due to the fact that Salmodyl is presented in the medicinal form of syrup, it is very convenient and easy to use.

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Indications Salmodil

Indications for the use of Salmodyl are to prevent bronchospasm in patients with bronchial asthma. And in cases of its occurrence, the use of the drug is justified as one of the entire complex of medical interventions aimed at relieving this condition.

In addition to helping to eliminate such a critical condition of the patient and its subsequent normalization, Salmodyl can play an important role in terms of preventing, to the extent possible, the development of prerequisites for the emergence of provoking factors or so-called triggers of bronchospasm. Taking the drug is indicated not only in connection with achieving favorable conditions under which remission of the disease occurs and its symptoms disappear, but also suggests minimizing the possibility of the appearance of such symptoms in the future.

Respiratory dysfunctions associated with bronchial asthma are caused by reversible airway obstruction. This pathological phenomenon is characterized by the occurrence of difficulties in the process of forced inhalation, and as a result, forced exhalation slows down. Reversible airway obstruction, in addition to being inherent in bronchial asthma, is also a common occurrence in the chronic stage of bronchitis. This is where Salmodyl finds another application.

Indications for the use of Salmodyl, therefore, come down to the expediency of its use mainly for the prevention of asthmatic attacks and bronchospasm, both in bronchial asthma and in chronic bronchitis, as well as for their relief in case of occurrence. Actually, these features determine the definition of the drug to the category of anti-asthmatic drugs.

Release form

Salmodyl is available in the form of a pleasantly smelling syrup for oral use, pink in colour and with a transparent consistency.

5 milliliters of the drug contain salbutamol (as salbutamol sulfate) - 2 mg, which is equal to 5 milliliters, and in the amount of 4 mg or, accordingly, also 5 ml - bromhexine in the form of its hydrochloride.

In addition to these two main active ingredients, there are other components: sodium citrate, citric acid monohydrate, aspartame, sodium benzoate, propylene glycol, cherry flavor, carmosine E122, menthol, hydroxypropyl methylcellulose E 4 M, purified water.

The syrup is contained in a bottle with a volume of 100 ml. The bottle is closed with a screw-on metal cap, on top of which is placed a special removable cap made of polyvinyl chloride with a graduation scale applied. The purpose of this cap is to act as a measuring container in order to ensure convenient, accurate dosing of the drug. 1 graduation line on the cap corresponds to a volume of syrup equal to 2.5 milliliters.

The bottle is placed in a cardboard box, where the manufacturer also includes a folded sheet of paper with instructions for use.

The syrup form of Salmodyl facilitates the absorption of this medicine in the human body and the beginning of its positive effect in a short time after taking it.

Pharmacodynamics

The pharmacodynamics of Salmodyl is manifested by the combined pharmacological action of the two main active components included in its composition.

The first of these is salbutamol, which is a synthetic sympathomimetic amine with beta-adrenergic properties and a tocolytic effect. Salbutamol acts primarily by stimulating beta-adrenergic receptors, with little or no effect on alpha-adrenergic receptors. Salmodyl is similar to beta-adrenergic receptors and, by increasing the enzymatic activity of adenyl cyclase, stimulates cyclic adenosine-3', 5'-monophosphates - AMP. One of the key features of AMP is that they act as a link in many reactions occurring inside cells. If we compare the effect produced on cardiac beta1 receptors with the measure of impact on beta-2 receptors of smooth muscle tissue of blood vessels, in the bronchi and in the uterus, it should be noted that the stimulating effect of salbutamol has a greater degree of expression mainly in the latter case.

Bromhexine, the second of the main ingredients of the drug, is a mucolytic agent that is used to help normalize respiratory functions that may be impaired due to the large amount of mucus secreted or its consistency being too viscous.

The pharmacodynamics of Salmodyl, based on this, allows us to characterize this medicinal product as a combination drug with bronchodilatory properties, which are demonstrated by salbutamol, as well as an expectorant effect produced by bromhexine.

Pharmacokinetics

The pharmacokinetics of Salmodyl at the current stage of development of medical science has not been sufficiently studied.

Dosing and administration

The method of administration and dosage of Salmodyl vary depending on the age of the patient to whom the drug is prescribed.

The age of the child at which the use of this medicinal product is permitted must be at least 7 years. Children aged 7 and older are prescribed to take the syrup orally three to four times a day in a dose of 2.5 to 5 milliliters.

Adults should take 3-4 doses of the drug during the day in an amount equal to 5-10 ml.

For greater convenience and accuracy in determining doses, the cap of the bottle with Salmodyl syrup has a graduated measurement. One mark is 2.5 ml, respectively.

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Use Salmodil during pregnancy

The use of Salmodyl during pregnancy is one of the list of existing contraindications to the use of the drug. In addition, it is recommended to refrain from Salmodyl during lactation and breastfeeding.

Contraindications

Contraindications to the use of Salmodyl may be individual in nature and, first of all, are associated with the presence of hypersensitivity or poor tolerance to any of the components of the drug in a particular patient.

Furthermore, factors that classify Salmodyl as a drug that is not allowed to be used include severe cardiovascular diseases and gastric ulcers. The drug should not be used during pregnancy and during the period of time during which the baby is breastfed.

In addition, Salmodyl is not prescribed to children under 7 years of age.

In addition, there are a number of clinical cases that do not require a categorical ban, but require careful weighing of all the pros and cons, and increased caution when prescribing and using the drug. These include, in particular, glaucoma, peptic ulcer, diabetes.

Be that as it may, and no matter how many positive reviews about the results of use you have come across, nevertheless, you should not forget that thoughtless self-prescription of the drug instead of the expected beneficial effect is quite capable of being harmful. One of the reasons for this is often insufficient attention or ignoring what contraindications there are to the use of Salmodyl.

Side effects Salmodil

Side effects of Salmodyl are manifested in the occurrence of all sorts of negative phenomena under unfavorable circumstances that can develop in connection with the use of the drug.

Often, side effects from Salmodyl include tachycardia, heart pain, and sometimes tremors.

The effect on the central nervous system results in the person taking the drug being in a state of increased irritability.

With a small frequency, a negative response may occur from the digestive system. Thus, the gastrointestinal tract reacts to the use of Salmodyl by the appearance of nausea and vomiting.

Overdose

Overdose of Salmodyl has symptoms similar to those characteristic of poisoning. It is characterized by the appearance of such negative phenomena as nausea and vomiting.

Therapeutic measures aimed at treating overdose are symptomatic in nature and consist of neutralizing the intoxication factor. To do this, first of all, it is necessary to help reduce the concentration and remove the substance that has a detrimental effect on the body. For this purpose, the patient who has overdosed on the drug should take activated carbon orally, and he also needs to wash out the stomach.

Interactions with other drugs

Interactions of Salmodyl with other drugs are reflected mainly in the observed tendency to increase hypokalemia in cases when any of the following drugs are taken simultaneously with the drug. These are: glucocorticoids, diuretics and xanthine derivatives.

In addition, the interactions of Salmodyl with other drugs are such that they make its use extremely undesirable before the patient is supposed to be put into a state of anesthesia.

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Storage conditions

The storage conditions for Salmodyl are not much different from the rules for storing many other medicines. One of the traditional conditions is the need to ensure that the drug is kept in a place where it is inaccessible to children.

The constant ambient temperature should not exceed 25 degrees Celsius.

Shelf life

The shelf life of the drug is 2 years from the date of manufacture, the date of which is indicated by the manufacturer on the packaging.