Medical expert of the article
New publications
Preparations
SAB® Simplex
Last reviewed: 03.07.2025
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
SAB® Simplex (trade names - Infacol, Espumisan, Disflatil, Simikol, Bobotik) contains as its main active ingredient a non-toxic inert surfactant simethicone. Simethicone is a polymethyloxane - light synthetic organosilicon (silicone) oils used in the production of industrial defoamers and lubricants. The main property of simethicone is the ability to destroy gas bubbles and thereby suppress foam formation.
The substance simethicone is also included in such gastroenterological drugs as Gestid, Meteospasmil, Almagel neo, Pepfiz.
SAB® Simplex contains the following excipients: sodium citrate (food additive E331), citric acid, sodium cyclamate (food additive E952), sodium benzoate (food additive E211), synthetic sweetener sodium saccharin, preservative sorbic acid (E200), high-molecular polymer of acrylic acid (carbomer 934 P), flavors (raspberry and vanilla), purified water.
Indications SAB® Simplex
Indications for the use of this drug are disorders of the digestive system associated with increased gas formation in the intestine. SAB® Simplex is used as a symptomatic remedy for flatulence, bloating, in pediatrics - for increased air ingestion when eating ( aerophagia ), gastrocardiac syndrome (Remheld syndrome), as well as after operations on the abdominal organs and intestines.
In addition, SAB® Simplex is used during the preparation period for such diagnostic examinations of the gastrointestinal tract as radiography, gastroduodenoscopy, ultrasound of the abdominal cavity and pelvic organs. The drug can be used in acute forms of poisoning with synthetic detergents with surfactants (surface-active substances).
[ 1 ]
Release form
The form of release of this drug is a suspension for oral administration. SAB® Simplex is available in 100 ml bottles with a dropper attachment (1 ml of the drug corresponds to 25 drops).
Pharmacodynamics
The active substance simethicone, by reducing the surface tension of the liquid fractions of the intestinal contents, promotes the physical destruction of gas bubbles, and also reduces their formation in cases of excessive intestinal gas formation (flatulence). The gases released under the action of SAB® Simplex are absorbed by the intestinal walls or excreted from the body. Therefore, this drug helps reduce discomfort and pain caused by stretching of the intestinal walls during flatulence.
Pharmacokinetics
Due to its chemical inertness, the active substance simethicone does not participate in any chemical reactions during its passage through the gastrointestinal tract, is not absorbed and is excreted from the body unchanged - through the intestines. There is no information regarding the pharmacokinetics of the excipients included in SAB® Simplex (no special studies have been conducted on humans or animals).
Dosing and administration
The dosage and duration of the course of taking SAB® Simplex is prescribed by a doctor. As a rule, SAB® Simplex is prescribed in case of increased gas formation in adults: 30-45 drops (1.2-1.8 ml) during or immediately after meals (in acute forms of flatulence, the suspension can be taken every 4-6 hours).
The dosage for taking the drug in pediatrics is as follows: infants and children from 1 year to 6 years old - 15 drops (0.6 ml) during or after meals (the suspension can be mixed with other liquids, including breast milk); children 7-15 years old - 20-30 drops (0.8-1.2 ml) per dose. The maximum daily number of doses is no more than 4-5.
The minimum single dose of SAB® Simplex for poisoning with detergents is 1 teaspoon (5 ml).
Use SAB® Simplex during pregnancy
The use of SAB® Simplex during pregnancy, according to the information from the drug manufacturers, does not affect the development of the fetus. And during lactation, its active substance does not enter breast milk.
However, the sorbic acid contained in this preparation (a preservative, food additive E200) can inhibit the production of some enzymes, in particular, catalase - a hemoprotein that accelerates the reaction of biological oxidation of toxic hydrogen peroxide (which is formed in the body during various oxidative reactions). And hydrogen peroxide accumulated in the body damages chromosomes, causing mutations.
In addition, this drug contains the food additive E952 (sodium cyclamate sweetener), which is banned in the food industry in the United States (since 1969) and Russia (since 2010). It is believed that this additive does not directly cause cancer, but it can enhance the effects of other carcinogens. In some cases, the additive E952 can be processed in the intestines to form conditionally teratogenic metabolites. Therefore, the use of products with the additive E952 during pregnancy is not recommended.
Contraindications
Contraindications for the use of SAB® Simplex include: a history of negative reactions to the main substance (simethicone) or hypersensitivity to the auxiliary components of this drug; intestinal obstruction.
[ 2 ]
Side effects SAB® Simplex
With the generally good tolerability of the indicated symptomatic drug, among its side effects (mainly among patients with hypersensitivity to the components) there are rare cases of systemic allergic reactions in the form of redness and itching of the skin, urticaria or skin rash.
If such manifestations of the action of SAB® Simplex occur, it is recommended to stop taking it and consult your doctor.
Overdose
Cases of overdose have not been described.
[ 7 ]
Shelf life
Shelf life: 3 years from the date of manufacture of the drug, which is indicated on the packaging.
[ 13 ]
Attention!
To simplify the perception of information, this instruction for use of the drug "SAB® Simplex" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.