Reopyrin

Reopyrin demonstrates pronounced analgesic, anti-inflammatory and antipyretic drug activity.

The drug helps to slow down the processes of PG biosynthesis, and at the same time inactivates the action of COX and prevents the binding of endoperoxides to free radicals. In addition, the drug suppresses the implementation of fatty peroxidation processes, and also weakens pain perception and inhibits the movement of pain impulses within the body. 

Indications Reopyrin

It is applied in case of such violations:

• having a non-infectious etiology of arthritis;
• neuralgia , and in addition, neuritis or polyneuritis;
• lesions affecting extra-articular tissues along with the spine, in which there is severe inflammation with pain;
• adnexitis , and in addition to this, polyserositis, pericarditis or lumbago;
• retinitis , iritis, or anterior uveitis;
• parametritis.

Release form

The release of the drug element is made in the form of an injection liquid, inside ampoules with a volume of 5 ml. There are 5 such ampoules inside the pack.

In addition, it is sold in the form of tablets - 10 pieces inside a cell pack. The box contains 2 such packs.

Pharmacokinetics

The drug is absorbed at a high rate inside the gastrointestinal tract. There is a powerful synthesis of the drug with blood protein.

Excretion is mainly done through the kidneys; part of the substance is excreted by the intestines. The average half-life is 78 hours.

Dosing and administration

The tablets are taken orally - for adults, the daily portion is 4-6 tablets for 3 applications. A child of 7-14 years old needs to take a 0.5-1-well tablet 3 times a day.

Injections of the medication are made at a low speed (for 1-2 minutes), intramuscularly - deep into the buttock muscle area.

In the case of rheumatic diseases, 1 ampoule of drugs is administered daily or every other day (if required).

With pathologies of a gynecological nature, 1 ampoule of liquid is used after 4-5 days, until the fever and pain disappear.

For a child 7-14 years old, 0.5-1 ml of medication is required 3 times a day (daily or every other day).

• Application for children

In pediatrics, the medication is used strictly under medical supervision, as well as in a hospital setting, where the patient is constantly monitored for urine readings with peripheral blood, as well as liver function.

Use Reopyrin during pregnancy

Pregnant women can be prescribed medication only if there are strict indications, with the permission of the attending doctor - because there is a potential risk of chromosome aberrations within lymphocytes.

There is no information available regarding whether it is safe to use Reopirin while breastfeeding.

Contraindications

The main contraindications:

• severe intolerance associated with the medication;
• chronic cardiomyopathy;
• heart rhythm disorders;
• diseases associated with the work of the liver / kidneys;
• pathologies affecting the hematopoietic organs;
• heart defects.

Side effects Reopyrin

Among the side symptoms:

• increased stool, severe nausea or stomach pain, ulcers in the gastrointestinal tract, as well as vomiting;
• drowsiness, tachycardia, and dizziness;
• delay in the excretion of water and salts inside the body;
• hives, epidermal rashes and itching;
• leukopenia, and besides this anemia or agranulocytosis;
• abscess or pain at the injection site.

Overdose

First, with poisoning, nausea and vomiting (at times bloody), hallucinations and psychosis develop. In severe stages of intoxication, a disorder of EBV values and the development of coma occurs. After 2-7 days, changes in ECG readings, jaundice, hematopoietic disorders and liver failure appear.

Interactions with other drugs

Rheopyrin potentiates the activity of antidiabetic agents, anticoagulants, barbiturates and sulfonamides.

In addition, it reduces the effect of griseofulvin, cephalosporins, diphenin and imipramine.

Storage conditions

Reopyrin must be stored in a place protected from moisture; temperature indicators - in the range of 15-25 ° C.

Shelf life

Reopyrin can be used for a 36-month term from the date of marketing of the pharmaceutical product.

Analogs

An analogue of the drug is the substance Pirabutol.

Reviews

Reopirin receives positive reviews from doctors. It is believed to be effective and well tolerated when a 5 ml dosage is used for 3 days.