Renitek

Renitek is a medication from the category of antihypertensive drugs. It contains an active element - enalapril maleate.

Inside the body, this component is converted into a form that has a therapeutic effect - into the substance enalaprilat, which has a powerful inhibitory effect relative to the ACE element. As a result of the suppression of the action of ACE, there is a decrease in the conversion of angiotensin-1 into angiotensin-2, as well as an increase in the activity of plasma renin and a weakening of the binding of aldosterone. [1]

Indications Renitek

It is used in the treatment of individuals with different stages of renovascular or primary hypertension .

It can be prescribed to people with HF - as a substance that increases the likelihood of survival, reduces the need for hospitalization, and also slows down the development of pathology.

It is used in the case of an asymptomatic disorder of left ventricular function to prevent the development of severe HF.

For persons with a disorder of left ventricular activity, a medication is prescribed to prevent the development of coronary ischemia.

It is used in people with unstable angina pectoris to prevent myocardial infarction and reduce hospitalizations.

Release form

The release of the drug substance is realized in tablets - 7 pieces inside the cell plate; inside the box - 2 or 4 such plates. Also, tablets can be packed in bottles - 100 pieces each (1 bottle inside a pack).

Pharmacodynamics

The use of the medication leads to an increase in the values of PG-E and NO, increases the excretion of sodium ions and insignificantly reduces the excretion of potassium ions, and in addition reduces the indices of circulating catecholamines.

Enalaprilat reduces blood pressure, and in people with primary hypertension it leads to a weakening of systemic resistance in the region of peripheral vessels and a slight increase in cardiac output. [2]

In persons with proteinuria and renal dysfunction, the treatment showed a weakening of albuminuria and a decrease in urinary excretion of the IgG element and systemic urinary protein. [3]

Enalaprilat stimulates the regression of left ventricular hypertrophy, while maintaining the systolic activity of this organ; in people with heart failure, the drug substance reduces the incidence of ventricular arrhythmias.

The drug has little effect on the processes of glucose and lipoprotein metabolism.

Pharmacokinetics

When ingested, the medicinal effect develops after 1-4 hours, after which it continues for 24 hours.

Dosing and administration

The medicine is taken orally by swallowing a whole tablet and drinking it with plain water. It doesn't need to be crushed or chewed. If necessary, dividing the tablet in half is allowed. You can use the drug without being tied to food.

To get the maximum medicinal effect with constant monitoring of blood pressure values, you should take the medication at the same time of the day. The duration of the treatment cycle and the size of the dosages are personally selected by the attending physician.

Adults with primary hypertension often take 10-20 mg of the medication 1 time per day. With insufficient effectiveness of the drug, its dosage is gradually increased. The recommended maintenance serving size is 20 mg. A maximum of 40 mg is allowed per day.

For an adult with renovascular hypertension, 2.5-5 mg of the substance is often required once a day. If there is no improvement, the dosage can be gradually increased. The maintenance serving size is 10-20 mg.

Persons who have taken diuretics shortly before starting the use of Renithek can initially use a maximum of 5 mg of the medication. The dosage can be gradually increased if there is no effect. The use of diuretics must be completed at least 2-3 days before starting to take Renitek.

People with renal disorders and a CC level within 30-80 ml per minute need to apply 5-10 mg of drugs once a day. With CC values in the range of 10-30 ml per minute, the medication is taken 1 time per day in a portion of 2.5-5 mg. If the CC values are less than 10 ml per minute, on the days when dialysis is carried out, 2.5 mg should be used once a day. The rest of the time, the portion is selected personally.

Persons with asymptomatic developing left ventricular disorder and heart failure need to take 2.5 mg of the medication once a day. It can be used in combination treatment of HF (for example, in combination with diuretics and digitalis medications). With good tolerance to drugs (without lowering blood pressure) or after correcting signs of hypotension, the portion is gradually increased. The maintenance dosage is 20 mg 1 time per day or 10 mg 2 times per day.

People with heart failure need to constantly monitor blood pressure, plasma potassium values, and kidney function.

The age group under the age of 16 with elevated blood pressure should take 0.08 mg / kg of the drug 1 time per day. If necessary, the portion can be gradually increased.

• Application for children

Do not prescribe Renitek to infants under 1 month of age and children whose CF values are less than 30 ml per minute / 1.73 m2.

Use Renitek during pregnancy

It is forbidden to use the medicine during pregnancy, unless there are strict indications for this. It is necessary to make sure that the woman is not pregnant before prescribing the medication.

Patients of reproductive age should use reliable contraception during treatment with Renitek. If conception still occurs, the medicine must be canceled immediately.

The use of drugs in the 2nd and 3rd trimesters can provoke the death of the fetus or newborn, the appearance of disorders in the work of the kidneys, hyperkalemia, pulmonary and cranial hypoplasia, and with this a decrease in blood pressure values in the fetus. It is necessary to closely monitor newborns whose mothers took medication during pregnancy.

If the drug needs to be taken during lactation, you should consult with your doctor about the need to stop breastfeeding.

Contraindications

It is contraindicated to use in case of severe personal intolerance to the elements of drugs and other medicines from the ACE inhibitors category.

It is not used in people with Quincke's edema, which is idiopathic or hereditary.

Also not prescribed for persons with glucose-galactose malabsorption, lactose intolerance or galactosemia.

Not introduced if the patient is undergoing hemodialysis sessions using high-permeability membranes.

The medication is used very carefully before performing operations and for disorders of EBV parameters (for example, hyponatremia or -volemia).

It is used with extreme caution if the patient has coronary artery disease, heart failure, renal disorders or cerebrovascular manifestations, and in addition, when treating with diuretics or hemodialysis sessions.

Caution is required when administered to people with aortic stenosis or stenosis affecting the arteries of one or both kidneys.

Side effects Renitek

The medication is often tolerated without complications. The side signs that sometimes arise are of low intensity and do not require discontinuation of the drug. Among the violations:

• problems with the liver and gastrointestinal tract: stool disorders, vomiting, loss of appetite, pain in the epigastric zone and nausea. Occasionally, intestinal obstruction, hepatitis, pancreatitis, or jaundice are observed;
• disorders associated with the function of the central nervous system and PNS: ear noise, headaches, increased fatigue, dizziness, emotional instability, asthenia, paresthesia, and disorder of the daily regimen. Confused consciousness and a state of depression are singly noted;
• lesions affecting the activity of the CVS: a decrease in blood pressure values (sometimes it reaches orthostatic collapse), arrhythmia, severe pain in the sternum, palpitations and angina pectoris. Occasionally (usually in people from the risk category) there is a development of a stroke or myocardial infarction;
• violations of hematopoietic function: neutro- or thrombocytopenia, as well as agranulocytosis;
• symptoms associated with urinary activity: oliguria, acute renal failure and renal dysfunction;
• change in test readings: an increase in the values of creatinine with urea, bilirubin and intrahepatic enzymes inside the blood plasma. A single increase in blood potassium values or a decrease in blood sodium values may be observed, and in addition, a decrease in hemoglobin with hematocrit;
• signs of allergy: itching, bronchial spasm, epidermal rashes, Quincke's edema, SS, urticaria and runny nose of allergic genesis;
• others: pharyngitis, baldness, dry cough, impotence, hyperhidrosis and visual disturbance.

Overdose

The use of excessively high portions of Renitek leads to the development of stupor and a strong decrease in blood pressure.

There is no antidote. In case of poisoning, gastric lavage and the use of enterosorbents are carried out (when less than 120 minutes have passed since the drug was taken). In addition, in the case of intoxication, against the background of which the blood pressure indicator drops sharply, 0.9% NaCl is introduced through infusion and the use of angiotensin-2.

To reduce the plasma level of enalaprilat, hemodialysis procedures can be performed.

Interactions with other drugs

Diuretic and antihypertensive substances in combination with medication lead to potentiation of the antihypertensive effect.

Administration together with potassium-sparing diuretics and potassium medications increases the likelihood of hyperkalemia.

The combination with lithium substances enhances their toxic properties and weakens the excretion of lithium.

The introduction of simultaneously with non-narcotic analgesics increases the likelihood of developing nephrotoxic activity.

Storage conditions

Renitec must be stored in a dry and dark place at temperatures ranging from 15-30 ° C.

Shelf life

Renitec can be used for a 30-month term from the date of manufacture of the medicinal product.

Analogs

Analogs of drugs are the substances Enap, Enam, Enalapril with Enalozide, as well as Co-Renitek and Berlipril.

Reviews

Renitek perfectly helps with high blood pressure, quickly reducing it. Of the advantages in the reviews, they also highlight the fact that the medication can be used without being tied to food. In addition, the possibility of taking drugs to maintain renal activity is also noted. Another advantage of the drug is its low cost.