Renato

Renalgan has intense antispasmodic, analgesic, and besides this weak anti-inflammatory therapeutic properties.

The drug is a complex tool, whose activity develops under the medicinal influence of its constituent components - pitofenone with sodium metamizole, and also fenpiverinium. It helps to eliminate severe pain or severe cramps that appear in a variety of diseases affecting various organs and systems of the human body.

Indications Renalgana

It is used in such situations:

• pains with different intensity and degree;
• muscle spasms of the internal organs (biliary, renal and intestinal colic, as well as cramps affecting the ureter and bladder), as well as  algomenorrhea.

It is prescribed for the treatment of signs of such pathologies: neuralgia, arthralgia and sciatica, and in addition myalgia. Along with this helps to eliminate the pain that occurs after surgery.

Release form

The release of the element produced in tablets - 10 pieces inside the plate.

In addition, it is realized in the form of a liquid for intramuscular injection and intravenous injections — inside ampoules with a capacity of 5 ml; in a box - 5 ampoules.

Pharmacodynamics

Metamizole sodium exhibits analgesic, antipyretic, and in addition, weak anti-inflammatory activity.

Pitofenon helps to relax smooth muscles in the region of internal organs.

Fenpiverine has a spasmolytic effect.

[1], [2], [3], [4],

Pharmacokinetics

The drug is absorbed at high speed after intramuscular injection. Bioavailability values are approximately 85%. Blood index Cmax is observed on average after 60 minutes.

Metamizole is synthesized with blood protein by 50-60%, and in addition it easily passes through the BBB and the placenta. The drug is subject to intense intrahepatic biotransformation; metabolic elements of drugs have medicinal activity.

Excretion occurs mainly through the kidneys - in the form of metabolic components.

[5], [6], [7],

Dosing and administration

The drug solution is required to be administered intramuscularly in portions of 2-5 ml of the substance. Repeat the procedure should be at 7-8 hour intervals. During the day, you can apply a maximum of 10 ml of drugs. This introduction should last for 2-3 days, and then the patient is transferred to Renalgan tablets.

Adolescents older than 12 years old and adults should use 1-2 tablets of medication for 1 use. Apply the drug is recommended after meals. A day consumes a maximum of 3 servings of the substance. Repeat the reception should be 6-8-hour intervals. Per day is allowed to take a maximum of 6 tablets. It is recommended to prescribe tablets after a course of injections of the medicine.

[12], [13], [14], [15], [16]

Use Renalgana during pregnancy

Renalgan can not be prescribed during breastfeeding or pregnancy.

Contraindications

The main contraindications:

• severe intolerance to the drug;
• blood pathology;
• CH or CHD, and besides this tachycardia;
• kidney or liver diseases;
• glaucoma, having a closed-angle character;
• BPH.

Caution is required in such situations:

• AND;
• failure of the liver or kidneys;
• reduced blood pressure values;
• strong sensitivity to substances NSAIDs or urticaria caused by the use of aspirin or other NSAIDs.

[8], [9], [10], [11],

Side effects Renalgana

When using the recommended servings, the drug is often tolerated without complications. Occasionally, there may be local signs of allergy (rash or itching), a burning sensation in the gastric area, dryness of the oral mucosa, dizziness, a decrease in blood pressure, headaches, tachycardia and hypohydrosis.

Due to prolonged use or use of large portions, thrombocyto- or leukopenia and agranulocytosis can develop, which manifest as an increase in temperature, chills, stomatitis and pain in the throat area.

Overdose

When intoxication such manifestations are noted: symptoms of a toxic-allergic nature, disorders of the gastrointestinal tract, signs of damage to the blood-forming organs and brain (in the form of dryness of the oral mucous membranes, nausea and stomach pains), and in addition, a decrease in blood pressure, drowsiness, convulsions, accommodation disorder, confusion consciousness and problems with renal activity.

[17], [18]

Interactions with other drugs

The use of the drug together with substances that suppress the central nervous system, as well as with alcoholic beverages can lead to a disorder of the psychomotor activity of the patient (drowsiness appears).

The combination of the drug and analgesics non-narcotic nature mutually potentiates their toxic properties.

The combination of Renalgan with chlorpromazine leads to the appearance of hyperthermia of a pronounced nature.

Penicillin, as well as radiopaque substances with colloidal blood substitutes should not be used during therapy with the use of drugs.

Tranquilizers and sedatives potentiate the anesthetic effect of the drug.

The toxic activity of the drug is enhanced in the case of use with oral contraception and antidepressants.

The therapeutic effect of reganol is weakened when combined with phenylbutazone.

[19], [20], [21], [22]

Storage conditions

Renalgan is required to be maintained at temperatures in the range of 8-15 ° C.

[23], [24],

Shelf life

Renalgan can be used for a 24-month period from the time the medication is sold.

[25],

Application for children

Not used for children under 5 years old.

Analogs

Analogues of drugs are the means Maksigan, Spazmadol, Baalgin with Realgin, and in addition Baralgetas, Spazmoblok, Baralginus and Reonalgon with Trinalgin. In addition, the list Spazmalgon with Spazganom and so on.

[26], [27]

Reviews

Renalgan generally receives positive feedback on the forums. There is a high therapeutic efficacy of drugs (especially with renal or intestinal colic, headaches or toothaches, and also after surgery).