Rectal analgesic and anti-inflammatory suppositories: for back pain, period pain, for children

Sometimes people who experience acute pain, for one reason or another, cannot take tablets or other medicinal forms orally - inside. In such situations, other medications can come to the rescue - rectal painkillers. This form of medication does not affect the digestive processes, being absorbed through the rectal mucosa, due to which the components of the drug quickly enter the bloodstream and almost instantly relieve painful sensations.

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Indications rectal pain reliever suppositories

Rectal pain-relieving suppositories will help to alleviate the patient's condition in a short time in case of acute pain associated with:

• with hemorrhoids;
• with prostatitis;
• with painful menstruation in women;
• with osteochondrosis, radiculitis, arthritis, osteoarthritis, spondylitis;
• with migraine;
• with gout;
• with back pain;
• with neuralgia, myalgia, injuries;
• with cystitis and other inflammatory diseases.

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Release form

The pharmacy chain can offer a wide range of all kinds of rectal pain-relieving suppositories, depending on the underlying cause and location of the pain, with or without an anti-inflammatory effect.

Names of pain-relieving rectal suppositories

• For hemorrhoids, pain-relieving suppositories of both local and systemic action are prescribed. For example, for mild hemorrhoids, you can use suppositories with herbal components - for example, sea buckthorn, or suppositories with calendula, as well as suppositories with anesthetics - Anestezol. In more advanced cases, rectal medications such as:
  • Proctozan-Neo is represented by such active ingredients as heparin (improves blood circulation and prevents thrombus formation), prednisolone (stops inflammation and allergic reaction) and polidocanol (relieves pain and itching). Proctozan-Neo is used to treat anal fissures and hemorrhoids in people over 18 years of age.
  • Proktozol is a local anesthetic suppository based on bufexamak, bismuth and lidocaine. The drug is one of the analogues of Proktozan suppositories.
  • Anuzol is a pain-relieving suppository used for hemorrhoids and anal fissures. The drug is made on the basis of xeroform, belladonna, zinc sulfate. Anuzol is not recommended for use in patients with arrhythmia, thyrotoxicosis and hypertension.
  • Relief is a well-known rectal analgesic suppository based on phenylephrine, a substance that eliminates itching, discomfort and pain in the anal area. Phenylephrine is not recommended for use in cases of severe high blood pressure, thromboembolism, and thyrotoxicosis.
• The following medications will help with pain associated with prostatitis:
  • Prostatilen is a unique suppository with prostate extract and glycine. The drug is non-toxic and causes virtually no side effects.
  • Vitaprost is a suppository based on prostate extract, which is prescribed for chronic prostatitis and prostate hyperplasia.
• For joint pain, the following rectal pain-relieving suppositories will be useful:
  • Revmalgin is a pain-relieving suppository containing the active ingredient meloxicam (a non-steroidal anti-inflammatory drug). Revmalgin is not suitable for treating patients with bronchial asthma, gastrointestinal ulcers and bleeding, and blood clotting disorders.
  • Diclofenac is another representative of non-steroidal anti-inflammatory drugs. It helps with back pain, neuralgia, myalgia, gout, colic. The drug is not recommended for erosions and ulcers of the digestive tract, as well as for serious disorders of the hematopoietic function.
• To relieve pain during menstruation, women often use:
  • Efferalgan is a safe suppository based on paracetamol, can be used by adults and children. Efferalgan is usually well tolerated by the body, only rarely dyspeptic reactions are possible.
  • Miralgan is a suppository containing paracetamol that can be used not only during menstruation, but also to relieve headaches, toothaches, muscle pain, as well as injuries and burns.
  • Acamol-Teva – suppositories with paracetamol, which have analgesic, antipyretic and anti-inflammatory properties.

Rectal painkillers for menstruation should always contain some kind of analgesic, such as paracetamol. This component not only eliminates pain, but also has an antipyretic effect. In addition, the drug is considered safe and is approved for use even in childhood.

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Pain Relieving Rectal Suppositories for Children

Before prescribing rectal painkillers to a child, the doctor must establish the cause of the pain: after all, the child himself is not yet able to tell what exactly is bothering him. Therefore, prescribing such drugs without diagnostics is not recommended.

Among the most common children's pain-relieving rectal suppositories, the following can be distinguished:

• Ibuprofen is a pain-relieving rectal suppository for children based on a non-steroidal anti-inflammatory component. Ibuprofen can be used from 3 months of age for pain of mild to moderate intensity.
• Cefekon is a children's suppository based on paracetamol. It can be used to relieve pain and high temperature in children from 3 months to 12 years.
• Viburkol is a homeopathic safe suppository that is effective in children for relieving toothache and cold symptoms.

Pharmacodynamics

Rectal analgesic suppositories can be used for two purposes: local anesthesia (for example, for hemorrhoids or inflammation of the rectum) and systemic anesthesia (for pain in other organs, such as joints or the prostate). In addition to the analgesic itself, most suppositories also contain antipyretic, antiplatelet and anti-inflammatory components. Systemic suppositories may contain non-steroidal anti-inflammatory agents: such suppositories include drugs with diclofenac, indomethacin, for example:

• Dicloberl suppositories 50, 100;
• Voltaren suppositories;
• Diclovit suppositories;
• Diclofenac sodium suppositories, Diclofenac Pharmex;
• Naklofen suppositories.

Suppositories for local use include Anestezol, Gemoproct, Gemorol, Novocain, Nigepan, Relief, Proctozan, Proctozol.

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Pharmacokinetics

The kinetic properties of locally acting rectal analgesic suppositories are not considered, since the active ingredients of such medications practically do not enter the systemic circulation.

As for rectal analgesic suppositories, which have a systemic effect, we can consider their kinetic properties using the example of non-steroidal anti-inflammatory drugs.

The absorption of the components of such suppositories occurs relatively quickly: the effect is observed within half an hour. The maximum concentration in the blood is detected in about an hour.

The binding of the active ingredient to plasma proteins is more than 99%.

The kinetic parameters of suppositories do not change depending on the frequency and duration of use of the drug.

About 60% of the drug is excreted from the bloodstream with urine. At the same time, approximately 1% of the active non-steroidal component is excreted unchanged. The remaining amount of the drug leaves the body with feces.

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Dosing and administration

To reduce the risk of side effects, any rectal pain relief suppositories should be used for the shortest possible period of time.

Rectal suppositories are used only rectally, without using other methods of drug administration.

The suppositories are inserted deep into the rectum: it is better if the procedure is carried out after preliminary cleansing of the intestines.

For one-time pain relief, use one suppository, usually at night. In case of severe pain, 2-3 daily administrations of the drug may be required, depending on the doctor's prescription.

The duration of treatment is also determined only by the doctor, taking into account the cause of the pain and the achieved therapeutic effect from the use of analgesic rectal suppositories.

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Use rectal pain reliever suppositories during pregnancy

Rectal analgesic suppositories in the first and second trimester are used only in cases where the expected effect of the drug is more important than the possible danger that suppositories with an analgesic pose to the fetus. If suppositories are nevertheless prescribed by a doctor to a pregnant woman, their dosage and duration of treatment should be as minimal as possible.

In the third trimester, the use of any suppositories with analgesics, including those with non-steroidal anti-inflammatory components, is contraindicated.

Active components of systemic suppositories in the vast majority of cases can be found in small quantities in breast milk. Therefore, such suppositories are not prescribed during the lactation period in order to protect the newborn child from unwanted drug exposure.

Contraindications

Rectal pain-relieving suppositories are generally not prescribed:

• in case of hypersensitivity to the composition of the suppositories;
• in case of exacerbation of peptic ulcer of the digestive organs, perforation complications and internal bleeding;
• for intestinal inflammation;
• in the last trimester of pregnancy;
• patients with severe renal and/or hepatic impairment;
• patients with severe heart failure;
• for the treatment of postoperative pain after coronary artery bypass grafting;
• for proctitis.

Suppositories based on non-steroidal anti-inflammatory components are not used to treat patients in whom any representatives of this series of drugs cause adverse reactions in the form of asthma attacks, Quincke's edema, skin rashes or allergic rhinitis.

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Side effects rectal pain reliever suppositories

Side effects during treatment with rectal analgesic suppositories may include:

• changes in the blood picture;
• allergic reactions;
• insomnia, irritability;
• tinnitus;
• tachycardia, chest pain;
• dyspepsia, diarrhea or constipation, bloating, colitis;
• liver dysfunction;
• redness and irritation of the anus;
• painful defecation, the appearance of mucus in the stool;
• potency disorders.

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Overdose

It is almost impossible to overdose on locally acting rectal analgesic suppositories. As for suppositories for systemic use, in this case an overdose may manifest itself as headache, nausea, abdominal pain, bleeding of the mucous membranes, diarrhea, drowsiness, and convulsions.

If the overdose is confirmed, the doctor prescribes symptomatic treatment with a cleansing enema and gastric lavage. Other additional measures are used depending on the clinical condition of the patient.

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Interactions with other drugs

No significant drug interactions have been identified for locally acting rectal analgesic suppositories.

Suppositories with a systemic effect are prescribed with caution in combination with diuretics, anticoagulants, oral non-steroidal anti-inflammatory drugs, blood sugar lowering agents, antibiotics and cardiac glycosides.

For more detailed information on drug interactions, be sure to check the instructions for specific rectal suppositories.

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Storage conditions

Rectal pain relief suppositories should be stored in a cool, dark place, out of reach of children, away from heat sources and sunlight.

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Shelf life

The shelf life of most suppositories is up to 3 years, but this point should be clarified in the instructions.

Rectal pain-relieving suppositories can be dispensed in pharmacies both upon presentation of a prescription and without it, depending on the active component of the suppositories. This issue should be clarified directly in pharmacies or with the attending physician.