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Rekut
Last reviewed: 04.07.2025
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Recut is an antimicrobial drug that contains clavulanic acid and amoxicillin.
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Indications Rekut
It is used as an antimicrobial agent with a wide range of effects – for therapy in such cases:
- mixed infections caused by the activity of anaerobes and gram-negative and -positive bacteria;
- lesions affecting the ENT organs (otitis media, tonsillitis, including recurrent tonsillitis, and sinusitis);
- damage to the respiratory tract (pneumonia or bronchitis);
- disorders affecting connective and bone tissues (this includes chronic osteomyelitis);
- problems in the area of soft tissues and epidermis (including wound lesions and phlegmon);
- lesions of the urinary tract (including urethritis with cystitis and pyelonephritis).
Release form
The drug is released in tablets with a volume of 500/125 and 875/125 mg.
Pharmacodynamics
Amoxicillin is an antibiotic from the penicillin group and has a wide range of therapeutic activity. Clavulanic acid is a substance that inhibits the activity of β-lactamases; it creates stable complex bonds with these elements that do not have activity, and also protects amoxicillin from decay.
The drug has a wide spectrum of antimicrobial action. It is active against amoxicillin-sensitive bacteria and resistant microbes that synthesize β-lactamases. It affects both gram-positive (staphylococci with streptococci, enterococci, etc.) and -negative bacteria (shigella with klebsiella, as well as salmonella and others).
Pharmacokinetics
Suction.
Clavulanate and amoxicillin completely dissociate within an aqueous solution at physiological pH values. After oral administration, both of these elements are well and rapidly absorbed. The process of their absorption can be optimized by using the drug at the beginning of a meal. The level of bioavailability of the components reaches about 70%. Their profile within the plasma is quite similar, and the period required to obtain peak values (Tmax) for both of them is about 60 minutes.
Distribution processes.
Approximately 25% of clavulanate and 18% of amoxicillin (from the total plasma value) are synthesized with protein. The distribution volume varies within the range of 0.3-0.4 l/kg (amoxicillin) and approximately 0.2 l/kg (clavulanate).
Animal tests have not shown any accumulation of these elements in any organs.
Like many penicillins, amoxicillin can pass into breast milk. It may also contain trace amounts of clavulanate. In addition, there is evidence that these components cross the placenta.
Exchange processes.
Some amoxicillin is excreted in the urine as inactive penicillic acid (approximately 10-25% of the initial dose). Clavulanate undergoes extensive metabolism and is then excreted in the feces and urine, and also as carbon dioxide in exhaled air.
Excretion.
The main route of excretion of amoxicillin is the kidneys, while clavulanate can be excreted by both the kidneys and other routes.
In healthy individuals, both components have approximately the same half-life of approximately 1 hour, and an average total clearance of approximately 25 L/minute. About 60-70% of amoxicillin and approximately 40-65% of clavulanate are excreted unchanged in the urine (during the first 6 hours after a single dose of 500/125 mg tablets).
When combined with probenecid, the excretion of amoxicillin is delayed, while the excretion of clavulanate through the kidneys is unchanged.
Old age.
In elderly people, there is a risk of weakened renal function, which is why it is necessary to select the dosage very carefully, and at the same time monitor the kidney function during therapy.
Persons with kidney disorders.
The overall serum clearance rates of amoxicillin with clavulanate decrease proportionally with decreasing renal function.
The decrease in drug clearance is more pronounced for amoxicillin, because it is excreted to a greater extent through the kidneys. In this regard, when prescribing doses to people with kidney problems, care must be taken to prevent excessive accumulation of amoxicillin, while maintaining the required clavulanate levels.
People with impaired liver function.
People with this disorder need to carefully select the dosage of the drug and constantly monitor liver function.
Dosing and administration
Rekut is used in a portion, the size of which is determined by the severity of the disease, the age and weight of the patient, as well as his condition. The dosage is selected by the attending physician.
Teenagers aged 12 and over and adults are often prescribed 1 tablet of 500/125 mg twice a day. If a severe stage of infectious lesion is observed, a tablet of 875/125 mg is taken twice a day.
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Use Rekut during pregnancy
The medication may be prescribed to pregnant women, provided there are vital indications, only in cases where the probable benefit from its use is more expected than the risk of any complications in the mother or fetus.
Recut penetrates into breast milk, which is why breastfeeding should be avoided during therapy.
Contraindications
Among the contraindications:
- the presence of a history of strong sensitivity to clavulanate, amoxicillin, antibiotics from the penicillin category, or other elements of the drug;
- hepatitis or cholestatic jaundice caused by past use of penicillin antibiotics.
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Side effects Rekut
Often, taking the drug causes the following side effects:
- gastrointestinal dysfunction: vomiting, diarrhea or nausea;
- allergy symptoms: urticaria, erythema multiforme, rashes, allergic vasculitis and anaphylaxis;
- thrombocyto-, neutro- or leukopenia, and in addition, hemolytic anemia and agranulocytosis;
- headaches or dizziness.
Rarely, hyperactivity, hematuria, seizures, tubulointerstitial nephritis, and antibiotic-associated colitis occur.
A reduction in negative symptoms is noted when taking the tablets at the beginning of a meal.
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Overdose
Poisoning can lead to disruption of the gastrointestinal tract (vomiting, diarrhea or nausea), and in addition to this, to stimulation of the central nervous system (convulsions, agitation, and insomnia).
To eliminate the disorders, symptomatic procedures and hemodialysis sessions are prescribed.
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Interactions with other drugs
Anticoagulants for oral use.
There are data on an increase in INR values in people who underwent maintenance therapy with warfarin or acenocoumarol in combination with amoxicillin. If combined administration is required, it is necessary to closely monitor the PT or INR values (in case of additional use or withdrawal of amoxicillin). In this case, it may also be necessary to change the dose of anticoagulants.
Methotrexate.
Penicillin antibiotics can reduce the excretion of methotrexate, which can increase its toxic properties.
Probenecid.
Combining Recut with probenecid is prohibited, because the latter weakens the excretion of amoxicillin through the renal tubules. Also, the use of probenecid can cause an increase in indicators and an extension of the period of amoxicillin in the blood (clavulanate does not have such an effect).
Allopurinol.
Combination with allopurinol may increase the likelihood of developing signs of allergy on the epidermis.
Like other antibiotics, the drug can affect the intestinal microflora, which reduces the reabsorption of estrogens and weakens the effectiveness of combined oral contraception.
Storage conditions
Rekut must be kept at temperatures no higher than 25°C.
Shelf life
Recut can be used within 24 months from the date of release of the drug.
Application for children
Recuta tablets should not be prescribed to pediatric patients (children under 12 years of age).
Attention!
To simplify the perception of information, this instruction for use of the drug "Rekut" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.