Razo

Razo is a medicinal antiulcer. Let's consider the instruction to the given medicine, that is indications to application and other features of use.

The active substance of the drug is rabeprazole, its mechanism of action is based on the inhibition of the specific enzyme H + / K + -AT Phase and affects the cells of the gastric mucosa. The active ingredient acts as an inhibitor of the proton gastric pump, blocking the formation of hydrochloric acid in the last stage. Depending on the dose of the drug, its substances inhibit the secretion of hydrochloric acid, regardless of the type of stimulus and its nature.

Once does not block H2 receptors, after intake completely absorbed in the gastrointestinal tract. The antisecretory effect works within an hour after taking a dose of 20 mg. The pH of the gastric environment is maximally reduced 3-4 hours after the administration of the first tablet and is maintained for three days. Bioavailability is about 50% due to passage through the liver and does not increase with a multiple dose. 

Once dispensed only by prescription. Despite the contraindications and possible side effects, rabeprazole has a significant therapeutic effect. But before using it, you should carefully read the instructions.

Indications Razo

Indications for use Reasonably based on the action of its active components. Tablets are prescribed for the treatment and prevention of such diseases as:

• Peptic ulcer of the stomach and duodenum.
• Functional dyspepsia.
• Chronic gastritis and lesions of the gastrointestinal tract with increased acid-forming function in the stage of exacerbation.
• Gastroesophageal reflux disease.
• Zollinger-Ellison syndrome.
• The presence of Helicobacter pylori in the schemes of eradication treatment (in combination with antibacterial agents).

[1], [2],

Release form

The form of release of the drug facilitates its use, since it allows you to calculate the dosage and the number of necessary techniques. Razo is released in the form of tablets of 10 and 20 mg, coated with a soluble coat, which dissolves in the stomach. 

The drug is produced in blisters for 10 tablets in each. In one package Razo 1-2 blisters. As a rule, this amount of medicine is enough for one course of treatment or preventive therapy.

[3], [4], [5]

Pharmacodynamics

Pharmacodynamics Pazo is a mechanism of action of the constituents of the drug after ingestion. The antisecretory drug belongs to the inhibitors of the benzimidazole group. It suppresses the secretion of the stomach by inhibiting enzymes and is activated in an acidic pH medium. Thanks to this, the active substances block the channel through which hydrogen ions pass through the lumen of the glands, which lowers the level of acid secretion. Regardless of the type of stimulant, rabeprazole stops the secretion of hydrochloric acid, having a bactericidal and cytoprotective effect.

20 mg of the substance has an antisecretory effect within an hour after ingestion and reaches its peak after 3-4 hours. Inhibition of the secretion of hydrochloric acid (basal-stimulated) is observed the day after admission. The antisecretory effect occurs 3 days after the beginning of the application. After the end of its reception, the secretory activity is restored after 2-3 days. Active substances are cleaved under the influence of hydrochloric acid, which is why it is advisable to use Pazo in an enteric-soluble form of release.

[6], [7], [8], [9], [10], [11],

Pharmacokinetics

Pharmacokinetics Razo is information about the absorption, metabolism and distribution of a drug.

• Absorption - rabeprazole has a high absorption, which does not depend on the time of application and food intake. After oral administration, the absolute bioavailability of the substance is 52% and does not increase with repeated use. The maximum concentration in the blood plasma is observed after 3-4 hours, while the AUC are linear.
• Distribution - the agent binds to plasma proteins, and the binding level is 97%.
• Metabolism - Once metabolized in the liver with the active participation of isoenzymes of the cytochrome P450 system.
• Excretion - 90% of active substances are excreted by the kidneys in the form of metabolites, the remaining 10% through the intestine. If the drug is taken by patients with hepatic insufficiency and elderly patients, the withdrawal period is 2-3 times increased. 

[12], [13], [14], [15], [16], [17], [18]

Dosing and administration

The method of administration and dosage of the pharmaceutical is selected by the physician, individually for each patient. Tablets are prescribed once a day, in the morning before meals, without crushing or chewing the granule. Duration of therapy is from 4 to 12 weeks. Consider ways to use Razo for various diseases:

• Chronic gastritis with exacerbation of increased acid-forming function - 20 mg twice a day, treatment course 2-3 weeks.
• Ulcerous gastroesophageal reflux or erosive disease - 20 mg once a day, course of therapy 4-8 weeks. If the ulcer is relapsing or with complications, the treatment can last up to 12 months. The maintenance dose is 10 mg rabeprazole.
• Peptic ulcer of the duodenum and stomach - 20-40 mg once a day or 10 mg twice a day. Duration of use from 2 to 4 weeks, with disease with complications up to 6 weeks.
• With Helicobacter pylori infection, medication is taken in combination with antibacterial agents. The dose of rabeprazole 20 mg twice a day for 7-8 weeks.
• Functional dyspepsia - 20 mg once or twice a day for 2-3 weeks.
• Zollinger-Ellison syndrome - 60 mg per day, while the duration of therapy is selected individually and depends on the tolerability of the drug and its therapeutic effect. The maximum dosage should not exceed 120 mg per day.

[22], [23], [24]

Use Razo during pregnancy

Use of Razo during pregnancy and breastfeeding is contraindicated. Since the drug has a negative effect on the well-being of the future mother and development of the fetus. The use of a medicinal product is possible if the therapeutic benefit for the mother is much more important than the possible harm to the baby. In any case, you can take the medicine only after medical permission.

If pregnancy requires urgent treatment or prevention of diseases of the gastrointestinal tract, then a woman is selected safe preparations. As a rule, preference is given to medicines on a plant basis with minimal side effects.

Contraindications

Contraindications to the use of Razo are based on the activity of the active ingredients and their effect on the body. It is forbidden to take once with individual intolerance of rabeprazole and other components of the drug, including those substituted with benzimidazoles.

The age of patients under 14, the period of pregnancy and lactation, also refer to contraindications for treatment and prophylaxis with rabeprazole. For more accurate information about the effect of the drug on the body and the prohibition on its use, you can check with your doctor.

[19], [20],

Side effects Razo

Side effects Razo arise when the recommendations of the medication specified in the instructions are not observed. Most often, the drug affects the digestive system, causing flatulence, diarrhea, nausea, asthenia. In addition, there may be a dry mouth, headaches, constipation, a violation of taste and increased activity of liver transaminases, increased sweating and changes in body weight in the direction of increase.

Drowsiness, dizziness and depressive state are possible when exposed to the central nervous system. Very rarely there are dermatological reactions, that is, a skin rash. Often diagnosed with leukopenia and thrombocytopenia, as a violation of the hematopoiesis system. Rabeprazole often causes rhinitis and pharyngitis, fever, back pain. In addition, there are side reactions from the musculoskeletal system, that is, spasms of calf muscles, myalgia. 

[21]

Overdose

Overdosing with tablets is possible if the recommended dose is not met, exceeding the duration of the application or not following the instructions described in the instructions. Most common side effects are manifested as headache, drowsiness, nausea, vomiting, dizziness, dry mouth, increased sweating.

To eliminate them use symptomatic or maintenance therapy. Dialysis is not performed, since it is not effective. There was no specific antidote. After the normalization of the body, you should consult a doctor to review the dosage of the medicine.

[25], [26], [27]

Interactions with other drugs

Interaction Razo with other drugs is possible with the permission of a doctor. The active substances do not enter into clinical interactions with other drugs metabolized by enzymes, such as, Vafarin, Idiazepam, Phenytoin or Theophylline. Rabeprazole does not cause a prolonged decline in the production of hydrochloric acid, so it can be used concurrently with drugs whose absorption is completely dependent on the pH of the stomach contents.

If Razo is used concomitantly with Ketoconazole, the concentration of the first in the blood plasma is reduced by 33% and the concentration of digoxin is increased by 22%. That is why, with any interaction, correction of the doses of all drugs is required. After the end of treatment, the endoscopic control is mandatory. This is necessary to exclude malignant tumors. With prolonged therapy, atrophic gastritis is possible. 

[28], [29], [30], [31], [32], [33], [34]

Storage conditions

The storage conditions are specified in the instructions and comply with the rules for storage of any other tablet preparations. The medicine should be kept in a dry dark place, inaccessible to children and protected from sunlight, the storage temperature should not exceed 25 ° C.

If the storage rules are not observed, the drug loses its properties and is prohibited to use. Since it can cause uncontrolled adverse reactions from many body systems. 

[35], [36], [37], [38],

Shelf life

Shelf life of the drug is 18 months from the date of production, subject to compliance with storage rules. After the expiration date the tablets must be disposed of. If they have changed color or got an unpleasant smell, but the expiration date has not passed yet, the remedy should still be thrown out. Since such changes indicate a failure to comply with the rules of storage and spoilage of the medicine.

[39], [40], [41], [42]