The drug should be used, given the existing official recommendations for antibiotic therapy, as well as information on local sensitivity to the antibiotic. The tolerability of clavulanate and amoxicillin is different in different terrains and can change over time. If it exists, it is required to study information about local sensitivity and, if necessary, perform a microbiological study and conduct a test for tolerability.
The range of recommended dosages depends on the pathogens observed in the body, as well as their sensitivity to antibacterial drugs. Together with this, the severity of the disease and the location of the infection, and in addition weight, age and kidney function of a person.
Children weighing ≥40 kg and adults are required to take 1750 mg of amoxicillin / 250 mg of clavulanate per day (the dose is 2 tablets). To divide the daily portion should be for 2 uses.
Children weighing <40 kg can take no more than 1000-2800 mg amoxicillin / 143-400 mg clavulanate per day (if the following method is prescribed).
The duration of the course is determined taking into account the clinical response of the patient. For certain infections (such as osteomyelitis), prolonged therapy is necessary.
Children weighing <40 kg: daily dose in the range of 25 \ 3.6-45 \ 6.4 mg / kg. Dose divided into 2 portions.
Dose sizes in the case of functional hepatic impairment.
You should take the drug carefully, regularly monitoring changes in the liver. Information on dosages in this case is not enough.
Dose sizes for functional renal impairment.
Rapiklav in the amount of 875/125 mg can be prescribed only to individuals whose QC index is at least 30 ml / minute. In the case of kidney failure, in which KK - less than 30 ml / minute, this form of medicine can not be used.
The tablet is taken whole, without chewing. If necessary, you can divide it in half, then swallow both halves.
The duration of the course is selected individually. Do not continue therapy for more than 2 weeks without assessing the patient's condition.
The process of treatment can begin with the introduction of the drug parenterally. In the future, a transfer to the reception inside.