Rapidol

Rapidol is an antipyretic analgesic drug. Contains the active substance paracetamol.

Indications Rapidola

It is indicated for the relief of pain of various origins:

• headaches (including migraines);
• toothaches (also in the case of teething in children);
• during pathologies of infectious and inflammatory genesis, which are accompanied by a state of fever (also as a result of vaccination);
• to relieve pain in joints or muscles, and also for neuralgia of traumatic or rheumatic origin;
• with algomenorrhea.

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Release form

The drug is released in the form of dispersed tablets. Tablets of 125 or 250 mg are released 6 pieces in 1 blister; a separate package contains 2 blister plates. Tablets of 500 mg are released 4 pieces in 1 blister; in a pack - 3 blister plates.

Rapidol Cold

Rapidol Cold is a powder from which an oral solution is made. It is included in the category of antipyretic drugs and painkillers. The composition of the drug includes paracetamol, the combination does not include psycholeptics. It is available in 5 g sachets. The pack contains 10 sachets of powder.

Rapidol retard

Rapidol retard is a prolonged-release tablet. Each container contains 10 or 20 tablets.

Pharmacodynamics

Paracetamol is 4-hydroxyacetanilide, which is a non-salicylate non-narcotic analgesic antipyretic, the analgesic properties of which are provided by peripheral and central action. The drug increases the pain sensitivity limit, and in addition, has a weakly expressed anti-inflammatory effect, suppressing the processes of PG synthesis and blocking impulses that arise inside conductors sensitive to bradykinin.

Pharmacokinetics

The drug is absorbed quite quickly and completely when taken orally. In the plasma, it reaches a peak 15-60 minutes after taking the tablet. The drug reaches an effective level in the plasma when tablets are prescribed at a dosage of 10-15 mg/kg.

Metabolism of paracetamol occurs mainly in the liver, through the process of conjugation with glucuronic and sulfuric acids. As a result, paracetamol sulfate and glucuronide are formed.

The active component is excreted through the kidneys, with less than 5% of the substance excreted unchanged. The half-life when taken orally is about 1-4 hours.

If the patient suffers from severe renal failure (creatinine clearance level less than 10 ml/minute), the excretion of paracetamol with its breakdown products is slower.

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Dosing and administration

The medicine is taken orally, after meals (after 1-2 hours).

For children under 6 years of age, the tablet should be dissolved in milk or water (a tablespoon is enough). It is better not to use fruit juice, as this may cause a bitter taste.

Adults and children over 6 years of age should dissolve the tablet. There is no need to chew it, because it dissolves quite quickly after mixing with saliva.

It is allowed to take no more than 10-15 mg/kg of the medicine at one time. The maximum daily dose is no more than 60 mg/kg of paracetamol.

For infants from 3 months, the medicine (tablet volume - 125 mg) is prescribed on the following basis: a single dose - within 10-15 mg / kg; maximum per day - 40-60 mg / kg. No more than 4 portions can be taken per day, and the intervals between doses - at least 4 hours.

For children aged 3 years and over, the medicine (250 mg tablets) is prescribed four times a day with an interval of 6 hours between doses.

Children over 7 years of age should take 250 mg tablets 6 times a day at 4-hour intervals.

Children aged 9 years and over are required to take 500 mg tablets four times a day at 6-hour intervals.

Adolescents aged 12 years and over and adults take the drug (500 mg) no more than 6 times a day with an interval of 4 hours.

Without a doctor's prescription, you can take pills for no more than 3 days.

The duration of the course of therapy is prescribed by the doctor. The prescribed dosage cannot be exceeded. It is also prohibited to use Rapidol with other drugs that contain paracetamol.

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Use Rapidola during pregnancy

Prescribing Rapidol to pregnant women is permitted only in cases where the benefit of the drug for the woman outweighs the likelihood of complications for the fetus.

The active component of the drug penetrates into the mother's milk, but its quantity is insufficient to manifest the medicinal effect. There is also no information about the prohibition of the use of drugs during lactation.

Contraindications

Among the main contraindications:

• intolerance to paracetamol and other components of the drug;
• severe functional liver or kidney disorders;
• congenital form of hyperbilirubinemia;
• G6PD deficiency;
• alcoholism;
• severe form of anemia, as well as leukopenia and pathologies in the hematopoietic system;
• children under 3 months of age.

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Side effects Rapidola

As a result of using the drug, side effects may develop (although paracetamol causes them quite rarely):

• immune reactions: manifestations of intolerance (including rashes on the mucous membranes and skin (mainly urticaria and erythematous and generalized rash), as well as itching), anaphylaxis, Lyell's or Stevens-Johnson syndromes and Quincke's edema;
• digestive system organs: epigastric pain and nausea;
• reactions of the endocrine system: development of hypoglycemia, which can lead to hypoglycemic coma;
• lymph and hematopoietic system: development of anemia (also hemolytic type), agranulocytosis with thrombocytopenia, and in addition methemoglobinemia (dyspnea, cyanosis and pain in the heart) and sulfhemoglobinemia, as well as the appearance of bleeding or bruising;
• respiratory disorders: development of bronchospasm in people with intolerance to aspirin and other NSAIDs;
• reactions of the hepatobiliary system: functional liver disorder, increased activity of liver enzymes (often without subsequent development of jaundice).

If side effects develop, it is recommended to stop using the medication and consult a doctor.

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Overdose

Signs of overdose: vomiting, pallor, nausea and development of anorexia, and in addition abdominal pain - they often occur during the first 24 hours.

The toxic effect of paracetamol intoxication in adults develops as a result of taking a single dose exceeding 10 g, and in children - more than 150 mg / kg. Noticeable symptoms of liver function damage occur after 12-48 hours; more rapid liver dysfunction develops less often (in this case, complications in the form of kidney failure may occur). Glucose metabolism disorders are possible, as well as the development of metabolic acidosis.

In case of severe intoxication, liver failure may progress to hypoglycemia, hemorrhage, encephalopathy, coma and death. Acute renal failure, accompanied by acute tubular necrosis, manifests itself as hematuria, severe pain in the lumbar region, and proteinuria. It may occur even without severe liver dysfunction. There are reports of pancreatitis and cardiac arrhythmia.

In case of prolonged use of the drug in large doses, the reaction of the hematopoietic system may be the development of agranulocytosis, thrombocytopenia, neutro-, leukopenia or pancytopenia, as well as aplastic anemia.

Overdose can cause CNS disorders, such as problems with attention and spatial orientation, dizziness, insomnia, a feeling of anxiety or nervousness, as well as tremors and psychomotor agitation.

Urinary system organs – development of nephrotoxicity (capillary necrosis, renal colic, and tubulointerstitial nephritis).

In case of overdose, tachycardia, hyperhidrosis, hyperreflexia and extrasystole may develop, as well as disturbance of consciousness, a feeling of drowsiness, tremors and convulsions, suppression of central nervous system function and disturbance of heart rhythm.

In individuals with certain risk factors (such as long-term use of phenobarbital, primidone, carbamazepine or phenytoin, as well as St. John's wort, rifampicin and other drugs that induce liver enzymes; regular use of ethanol in large quantities; glutathione form of cachexia (there is a violation of the digestive process, HIV, starvation and cystic fibrosis)) the use of 5+ g of paracetamol can provoke liver damage.

The victim must be hospitalized immediately (even in the absence of early signs of overdose). Signs of the disorder may be limited to vomiting with nausea or may not reflect the severity of the disorder and the likelihood of damage to systems and organs.

If a large dose of the drug was taken within 1 hour, activated charcoal can be taken. Plasma paracetamol levels should be measured at least 4 hours after taking the drug, as earlier assessments do not provide reliable data.

N-acetylcysteine may be used within 24 hours of taking Rapidol, but the maximum protective effect of this substance can be achieved when taken within 8 hours of taking an excessive dose. After that, the properties of the antidote are significantly weakened. If necessary, N-acetylcysteine may be administered intravenously, in accordance with the required dosage list. In the absence of vomiting, methionine may be taken orally – an alternative method if hospitalization is not possible.

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Interactions with other drugs

The rate of absorption of the active component of the drug increases in the case of combination with domperidone or metoclopramide, and in the case of combination with cholestyramine, on the contrary, it decreases.

The anticoagulant effect of warfarin, as well as other coumarins, increases in the case of combined use of paracetamol (long-term daily use). This increases the likelihood of bleeding. It should be noted that periodic use of Rapidol does not have a significant effect.

The antipyretic properties of paracetamol are weakened when combined with barbiturates.

Anticonvulsants (including barbiturates with phenytoin and carbamazepine), which stimulate the work of microsomal liver enzymes, can increase the toxic effect of paracetamol on the liver, since this combination increases the degree of conversion of the substance into hepatotoxic decay products.

Combination of Rapidol with hepatotoxic drugs increases the toxic effect of the drug on the liver. When combining large doses of paracetamol with the substance isoniazid, the likelihood of hepatotoxic syndrome increases.

The medicine weakens the effect of diuretics.

It is forbidden to take Rapidol together with alcoholic beverages.

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Storage conditions

Rapidol should be kept in a dark place, away from moisture, and out of reach of children. Temperature level – maximum 25°C.

Shelf life

Rapidol in doses of 125 and 250 mg can be used for a period of 3 years, and in doses of 500 mg – 4 years from the date of release of the drug.