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Last reviewed by: Aleksey Portnov , medical expert, on 01.06.2018

Rapidol is an antipyretic analgesic medicine. Contains active substance paracetamol.

Indications of the rapidola

It is indicated for the elimination of pain sensations of different origin:

  • headaches (including migraines);
  • toothache (also in the case of teeth cutting in children);
  • during pathologies of infectious and inflammatory genesis, which are accompanied by a fever (also due to vaccination);
  • to eliminate pain in the joints or muscles, and in addition to neuralgia, having a traumatic or rheumatic nature;
  • with algodismenorrhea.

Release form

The release is carried out in the form of dispersed tablets. Tablets with a volume of 125 or 250 mg are available in 6 units in the 1 st blister; Inside a separate package contains 2 blister plates. Tablets with a volume of 500 mg are available on 4 pieces on the 1st blister; in a pack - 3 blister plates.

Rapidol Cold

Rapidol is a powder from which an oral solution is made. Included in the category of antipyretic drugs and painkillers. The drug includes paracetamol, the combination does not include psycholeptics. Available in bags of 5 g. Inside the pack contains 10 sachets of powder.

Rapidol retard

Rapidol retard is a tablet with prolonged exposure. Inside a separate container contains 10 or 20 tablets.


Paracetamol is 4-hydroxyacetanilide, which is non-salicylate non-narcotic analgesic antipyretic, whose analgesic properties are provided by peripheral and central effects. The drug raises the border of pain sensitivity, and besides it has a weakly expressed anti-inflammatory effect, suppressing the synthesis of PG and blocking the impulses that appear inside the bradykinin sensitive conductors.


The medicine is quickly and completely absorbed when taken orally. Inside the plasma, it reaches a peak 15-60 minutes after the use of the tablet. The substance achieves a medicinally effective level inside the plasma when the tablets are administered at a dosage of 10-15 mg / kg.

Metabolism of paracetamol mainly occurs inside the liver, through the process of conjugation of glucuronic, as well as sulfuric acids. As a result, paracetamol sulfate and glucuronide are formed.

Excretion of the active component is carried out through the kidneys, while less than 5% of the substance is excreted unchanged. The half-life for oral use is about 1-4 hours.

If the patient suffers from a severe form of kidney failure (CC level less than 10 ml / minute), the excretion of paracetamol with its decay products is slower.

Use of the rapidola during pregnancy

Rapidol is prescribed for pregnant women only in cases when the benefits of a medicine for a woman exceed the probability of complications in the fetus.

The active ingredient of the drug penetrates into the mother's milk, but its quantity is not enough to manifest the medicinal effect. There is also no information on the prohibition of the use of drugs during lactation.


Among the main contraindications:

  • intolerance to paracetamol and other components of the drug;
  • functional hepatic or renal disorders in severe form;
  • congenital form of hyperbilirubinemia;
  • deficiency of the G6FD component;
  • alcoholism;
  • pronounced form of anemia, as well as leukopenia and pathology in the hemopoietic system;
  • children age less than 3 months.

Side effects of the rapidola

Due to the use of the drug, side effects may develop (although paracetamol causes them quite rarely):

  • immune reactions: manifestations of intolerance (among them rashes on the mucous membranes with the skin (mainly urticaria and eruptive rash and generalized type), and itching), anaphylaxis, Lyell's syndrome or Stevens-Johnson syndrome, and Quincke's edema;
  • organs of the digestive system: epigastric pain and nausea;
  • reactions of the endocrine system: the development of hypoglycemia, which can reach hypoglycemic coma;
  • lymph and hematopoietic system: development of anemia (also hemolytic type), agranulocytosis with thrombocytopenia, and in addition methemoglobinemia (dyspnoea, cyanosis and pain in the heart) and sulphoglobinemia, as well as bleeding or bruising;
  • disorders in the respiratory tract: the development of bronchospasm in people with intolerance to aspirin and other NSAIDs;
  • reactions of the hepatobiliary system: functional hepatic impairment, increased activity of liver enzymes (often without the subsequent development of jaundice).

With the development of side effects, it is recommended to cancel the use of medication and consult a doctor for advice.

Dosing and administration

The medicine is taken orally after eating (after 1-2 hours).

For children under 6 years of age, you should dissolve the tablet in milk or water (a tablespoon is enough). Fruit juice is best not to use, because in this case, the appearance of bitter aftertaste.

Adults and children over 6 years of age need to dissolve the pill. You do not need to chew it, because it dissolves rather quickly after mixing with saliva.

Once allowed to use no more than 10-15 mg / kg of the drug. The maximum value for a day is not more than 60 mg / kg of paracetamol.

Infants from 3 months of medication (the volume of tablets - 125 mg) is prescribed from this calculation: a single dose - within 10-15 mg / kg; maximum for a day - 40-60 mg / kg. For a day, you can take no more than 4 servings, and the intervals between receptions - at least 4 hours.

In childhood from 3 years, a drug (250 mg tablets) is prescribed four times a day with an interval between uses of 6 hours.

Children over 7 years old need to take 250 mg tablets six times a day with an interval of 4 hours.

At the age of 9 years, it is required to take 500 mg tablets four times a day with an interval of 6 hours.

Adolescents from 12 years and adults take drugs (500 mg) no more than 6 times a day with an interval of 4 hours.

Without prescribing a doctor, you can take pills no more than 3 days.

The duration of the course of therapy is prescribed by the doctor. The prescribed dosage can not be exceeded. It is also forbidden to use Rapidol with other drugs, which contain paracetamol.


Signs of an overdose: vomiting, pallor, nausea and the development of anorexia, and besides this abdominal pain - they often occur during the first 24 hours.

The poisoning effect of paracetamol intoxication in an adult develops as a result of taking a single dose exceeding 10 grams, and in a child - more than 150 mg / kg. Notable symptoms of liver function damage occur after 12-48 hours; a more rapid breakdown in liver function is less common (with complications in the form of kidney failure). Possible disorders of glucose metabolism, as well as the emergence of metabolic acidosis.

In case of severe intoxication, liver failure can progress, transforming into hypoglycemia, hemorrhage, encephalopathy, as well as coma and death. The acute form of kidney failure, accompanied by acute tubular necrosis, manifests itself under the guise of hematuria, severe pain in the lumbar region, and proteinuria. It can occur even without severe disruption in the functioning of the liver. There is information about the development of pancreatitis and cardiac arrhythmia.

In the case of prolonged use of the drug in large doses, the reaction of the hematopoietic system may be the development of agranulocytosis, thrombocyto-, neutro-, leuco- or pancytopenia, as well as aplastic form of anemia.

Overdosing can trigger CNS disorders: such as attention and spatial orientation problems, dizziness, insomnia, anxiety or nervousness, as well as tremor and psychomotor agitation.

The organs of the urination system - the development of nephrotoxicity (necrosis of capillaries, colic in the kidneys, as well as tubulointerstitial nephritis).

In case of an overdose it is possible to develop tachycardia, hyperhidrosis, hyperreflexia and extrasystole, and in addition, a disorder of consciousness, a feeling of drowsiness, tremors and convulsions, suppression of the central nervous system and a violation of the rhythm of the heartbeat.

Persons with certain risk factors (such as prolonged use of phenobarbital, primidon, carbamazepine or phenytoin, as well as St. John's wort, rifampicin and other drugs that induce hepatic enzymes, regular use of ethanol in large quantities, glutathione form of cachexia (there is a violation of the digestive process, HIV, famine and cystic fibrosis)) the use of 5+ g of paracetamol can provoke liver damage.

It is required to immediately hospitalize the victim (even in the absence of early manifestations of an overdose). Symptoms of impairment may be limited to vomiting with nausea or not reflect the severity of the disorder and the likelihood of damage to systems and organs.

In the event that a large dose of drugs was consumed within the first hour, you can drink activated charcoal. The plasma level of paracetamol should be measured at least 4 hours after the drug is used, because earlier estimates do not provide reliable data.

Use N-acetylcysteine is allowed within 24 hours after the use of Rapidol, but the maximum protective effect of this substance can be achieved with admission within 8 hours after taking an excessive dose. Further, the properties of the antidote are dramatically weakened. If necessary, N-acetylcysteine can be administered intravenously, in accordance with the required dosage list. In the absence of vomiting, it is permitted to take methionine - an alternative method if there is no possibility of hospitalization.

Interactions with other drugs

The rate of absorption of the active component of the drug increases in the case of a combination with domperidone or smetoclogramide, and in the case of a combination with cholestyramine, on the contrary, decreases.

The anticoagulant effect of warfarin, as well as other coumarins, increases in the case of combined use of paracetamol with it (long-term daily intake). This increases the likelihood of bleeding. It should be noted that the periodic use of Rapidol has no significant effect.

The antipyretic properties of paracetamol are weakened when combined with barbiturates.

Anticonvulsants (among them barbiturates with phenytoin and carbamazepine), stimulating the work of microsomal hepatic enzymes, can increase the poisoning effect of paracetamol on the liver, as this combination increases the degree of conversion of the substance into hepatotoxic degradation products.

The combination of Rapidol with hepatotoxic drugs increases the toxic effect of drugs on the liver. When combining large doses of paracetamol with an isoniazid substance, the likelihood of a hepatotoxic syndrome increases.

The drug weakens the effect of diuretics.

It is forbidden to take Rapidol together with alcoholic beverages.

Storage conditions

Rapidol should be kept in a dark place, where moisture does not penetrate, and also inaccessible to children. The temperature level is a maximum of 25 ° C.

Shelf life

Rapidol in doses of 125 and 250 mg can be used in the period of 3 years, and in doses of 500 mg - 4 years from the date of release of the drug.

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To simplify the perception of information, this instruction for use of the drug "Rapidol" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

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