Ranostop

Ranostop is an iodized product, disinfectant antiseptic medicine.

Indications of the ranostopa

The ointment is indicated as a prophylactic against infections with a minor amount of abrasions or cuts, as well as burns and small surgical operations. In addition, it is used to treat skin infections (most often bacterial or fungal type), and along with it ulcers of the trophic type and bedsores in which the infection develops.

Release form

Produced in an ointment form. The volume of the tube can be 20, 40 or 100 g. Inside a separate package contains 1 tube of ointment.

Pharmacodynamics

The active component of the drug is povidone-iodine. This is a complex iodine compound with polymer E1201, releasing iodine for some time after treatment with ointment. Elementary iodine has a bactericidal effect and has a fairly wide range of antimicrobial effects against various viruses with bacteria, and besides fungi with protozoan microbes.

The medicine operates according to the following scheme: free iodine has a rapid bactericidal effect on the body, and the polymer acts as a depot for this component.

After contact with the mucous membranes and skin, the polymer releases a large amount of iodine.

Iodine interacts with hydroxyl, as well as oxidation-sulfide particles of amino acids, which are constituent elements of enzymes and protein structures of microbes. It helps to destroy or suppress the activity of these proteins. Many microbes disappear under in vitro action very quickly (less than 1 minute is required), the main destructive effect occurs in the initial 15-30 seconds. In the process, iodine discoloration occurs, so a change in the shades of brown saturation is considered a pointer to the effectiveness of the substance.

The active component of the drug is able to influence gram-negative and gram-positive microbes (bactericidal effect), and in addition to this fungus (fungicidal effect), viruses (virucidal effect), fungal spores (sporicidal effect) and individual simple microbes (protozoal effect). The mechanism of action of the Ranostop does not cause the development of resistance (this includes a secondary form of resistance in the case of prolonged use of the ointment).

Ointment is easy to wash off with water, because it dissolves well in it.

Prolonged treatment of wounds or severe burns in large areas of the skin / mucous membranes can cause a significant absorption of iodine. Often, after prolonged use of drugs in the blood, the level of iodine increases. This indicator returns to its initial value 1-2 weeks after the last time the ointment application procedure.

Pharmacokinetics

Povidone-iodine absorption rates have similar characteristics to the usual iodine characteristics.

The distribution volume is approximately 38% of the weight, and the half-life (with intravaginal application) is approximately 2 days. The standard total iodine index within the plasma is about 3.8-6 μg / dl, and its inorganic form is 0.01-0.5 μg / dL.

Excretion is mainly carried out by the kidneys. The clearance is 15-60 ml / minute (the exact figure depends on the plasma iodine index, as well as the level of QC (the norm is 100-300 μg iodine in the 1st g of creatinine)).

Dosing and administration

The medicine is applied to the skin locally.

In the treatment of infectious processes, it is required to treat affected areas 1-2 times per day. In case of prophylaxis, treatment is 1-2 times a week, while this is necessary.

The product should be applied to a dry and clean skin, a thin layer. After the procedure is completed, a bandage is allowed to be applied to the affected area of the skin.

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Use of the ranostopa during pregnancy

Povidone-iodine component does not have teratogenic properties, but it is used during pregnancy after the 2nd month, and during lactation it is forbidden (in the latter case, if it is necessary to use drugs, it is necessary to cancel breastfeeding for the duration of treatment). Iodine can penetrate the placenta, as well as into the mother's milk.

Contraindications

Contraindications are the following problems:

• high sensitivity to iodine or other elements of drugs;
• the presence of adenoma, thyrotoxicosis or disorders in the thyroid gland (for example, colloid goiter (nodular type) or diffuse goiter, as well as autoimmune thyroiditis);
• Duhring's dermatitis (herpetiform type);
• the time interval before the course of treatment with the use of radioactive iodine (or after its completion);
• kidney failure.

Newborns, as well as infants until 1 year of the medication is allowed to use only if there are strict indications.

Side effects of the ranostopa

As a result of using the ointment, these side effects can develop:

Indications of tests: development of metabolic acidosis, changes in serum electrolytes (occurrence of hypernatremia), and also osmolarity;

Urinary system and kidneys: acute form of kidney failure and functional renal impairment;

Subcutaneous layers and skin: local manifestations of increased sensitivity (contact-type dermatitis, against which a small bullous rash of red color is formed, similar to psoriasis), and in addition allergies in the form of redness, itching and eruptions, and Quincke edema;

Reactions of the endocrine system: the development of thyrotoxicosis. In the case of prolonged use of povidone iodine, the level of iodine in the body may increase.

There have been reports of cases of thyrotoxicosis caused by iodine (with prolonged use of the ointment). Often such a problem was observed in people already having thyroid disease.

Single negative general manifestations were noted in acute form - a decrease in blood pressure and a difficulty in the respiratory process (anaphylactic reactions).

Overdose

In acute iodine poisoning, the following symptoms are observed in a person: appearance of metal taste, increased salivation, pain or burning sensation in the pharynx / oral cavity. In addition, there is swelling in the eyes and irritation. Gastrointestinal disorders, skin reactions, functional renal impairment with anuria and blood circulation problems develop. Possible laryngeal edema, growing into secondary asphyxia, pulmonary edema, the development of hypernatremia and metabolic acidosis.

Eliminate overdose with supportive treatment and getting rid of the symptoms of the disorder. Particular attention should be paid to the work of the kidneys and thyroid gland, as well as the electrolyte balance index.

Interactions with other drugs

The active substance of the drug most effectively affects pathogenic microbes at pH values 2-7. When combined with proteins and other organic structures, the activity of drugs is weakened.

Combined use together with enzyme wound healing ointments weakens the effectiveness of both drugs.

It is possible to develop interaction with the active component of Ranostop when combined with medications containing silver and mercury, as well as taurolidine and hydrogen peroxide, which is why it is forbidden to use such combinations.

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Storage conditions

The medicine must be kept in a place inaccessible to children. The temperatures of the storage area - a maximum of 25 ^{on the} S.

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Shelf life

Ranostop is allowed to be used for 2 years after the release of the medicinal ointment.