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Ranigast
Last reviewed: 23.04.2024
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Ranigast is a drug with antiulcer effect. The receptor antagonist (H-2).
Indications Ranigast
Among the indications for the use of drugs: ulcers of the duodenum gut or stomach (not only for treatment, but also for the prevention of the disease), gastrinoma, GERD, as well as erosive form of esophagitis arising after diagnostic procedures. It can also be used to treat dyspepsia, in which there is an increased acidity of the stomach (among the symptoms of eructation sour, heartburn, etc.).
Release form
Produced in the form of tablets. One blister plate contains 10 tablets, in one package on the first blister.
Pharmacodynamics
The drug is a blocker of the histamine receptors (H2) located in the gastric lining cells. Among its properties - the weakening of stimulated, as well as basal secretion of hydrochloric acid, and in addition a decrease in the activity of pepsin.
Pharmacokinetics
Absorption from the gastrointestinal tract is 50%, regardless of food or taking antacids. The peak concentration (478 μg / ml) reaches 2.63 hours, and the half-life is 2 hours. The distribution volume is 1.53 l / kg. Passes through the blood-brain barrier and penetrates into breast milk (it accumulates in concentrations approximating to plasma - about 25-100%). Metabolism occurs in the liver (oxidative process for sulfur or nitrogen, or demethylation) - about 1% of the substance. Excretion is carried out through the kidneys.
Dosing and administration
The medicine is taken orally, without chewing, with water.
With ulcers of the duodenum or stomach, the dosage is 150 mg twice a day (in the mornings and evenings) or once a day (at bedtime) at a dose of 300 mg. This course lasts 1-2 months. As a prophylaxis against the development of relapse, take 150 mg of the drug at bedtime.
With gastrinoma, the initial dosage of the drug is 150 mg twice a day (total 300 mg / day). If necessary, it can be increased to 600 mg.
With GERD, the daily dosage is also 300 mg (divided into 2 receptions of 150 mg).
With erosive form, esophagitis is prescribed 150 mg four times a day.
If the patient has a severe degree of renal failure (Cl creatinine is less than 50 ml / min), the daily dosage should be reduced to 150 mg (before bedtime).
Ranigast in 75 mg tablets (whole) is taken with manifestations of dyspepsia - a maximum of 1-2 times per day.
[2]
Use Ranigast during pregnancy
Conducting controlled tests with the use of drugs in pregnant women was not carried out, so it is strictly forbidden to assign it to women during this period.
Contraindications
Among the contraindications: individual intolerance of elements of drugs, lactation period, and also children's age less than 12 years.
Side effects Ranigast
Among the side reactions to taking medication:
- organs of the National Assembly: dizziness with headaches, vision problems, insomnia or vice versa, a feeling of drowsiness, as well as ataxia. In rare situations, there is a feeling of increased arousal, a state of depression, confusion and the development of hallucinations;
- cardiovascular, and hematopoietic systems: AV-blockade, tachycardia or bradycardia, development of hypotension or ventricular extrasystole, and in addition thrombocytopenia, granulocyte, and leukopenia;
- organs of the digestive tract: vomiting with nausea, pain in the abdomen, diarrhea or constipation, disorders in the functioning of the liver; in rare cases - acute form of pancreatitis;
- allergy: skin itching and rashes, problems with respiratory function, Quincke edema, bronchial spasms, and hyperthermia;
- other reactions: pain in the joints and muscles.
[1]
Overdose
As a result of an overdose, side effects of drugs may increase. In such cases, supportive and symptomatic therapy should be used as a treatment. Remove the active substance of the drug (ranitidine) from the blood serum using hemodialysis.
Storage conditions
It is necessary to keep the medicine under standard conditions - a place closed from light and moisture, inaccessible to children. Temperature mode - no more than 25 ° С.
Shelf life
Ranigast is allowed to be used within 3 years from the date of manufacture of the medicinal product.
Attention!
To simplify the perception of information, this instruction for use of the drug "Ranigast" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.