Ranisan

Ranisan is a drug with antiulcer properties.

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Indications Ranisan

Among the indications: gastric ulcers or 12-colon, and in addition reflux-esophagitis, pathologies with a high level of gastric acidity, and gastrinoma.

Release form

Produced in the form of tablets. One blister contains 10 tablets. In the package 1 blister plate (75 mg tablets) or 2 (tablets with a volume of 150 mg).

Pharmacodynamics

The main property of the drug is an antiulcer effect. The drug helps to reduce the production of acid, and is also a blocker of the receptors (H2) of histamine.

Pharmacokinetics

Absorption of the drug is quite high (the bioavailability is not affected by food, as well as taking antacid medicines).

It weakly passes through the blood-brain barrier, but it must be taken into account that the concentration of the active substance in breast milk is higher than in the blood plasma.

Excretion occurs through the kidneys. About 70% of the medication is unchanged.

Dosing and administration

Take it orally, regardless of food intake. Tablets do not need to be chewed, just drink with water.

If the ulcer of the duodenum gut or stomach during the exacerbation of a dose of 150 mg twice a day (in the morning and in the evening) or a one-time intake of 300 mg at bedtime. If necessary, you can drink 300 mg of medication twice a day. Therapeutic course lasts 1-2 months. As a prophylaxis against exacerbations, you should drink 150 mg of the drug at bedtime.

Ulcers that result from the use of NSAIDs should be treated with a dosage of 150 mg twice daily or 300 mg at bedtime. You need to take the medicine for 2-3 months. Prevention of ulceration when taking NSAIDs - 150 mg 2 times a day.

For the treatment of postoperative ulcers Ranisan is prescribed at a rate of 150 mg twice a day for 1-2 months.

When GERD is prescribed a dose of 150 mg twice a day or a one-time intake of 300 mg at bedtime. If necessary, the dosage can be increased to a 4-time intake of the drug at a dosage of 150 mg (daily dose, thus, 600 mg). Therapeutic course lasts 2-3 months.

With gastrinoma, the initial dose is 150 mg three times per day. If necessary, dosage may be increased.

To eliminate dyspeptic symptoms (against a background of increased levels of gastric acidity) - such as nausea, as well as heartburn with acidic eructations, etc. - 75 mg should be taken 1-2 times per day.

For prevention against recurrence of bleeding, it is required to drink 150 mg of medication twice a day.

For prevention against the development of acid-aspirating pneumonitis, the drug is drunk in a dosage of 150 mg before the injection of narcosis (for 2 hours). It is also advisable to drink 150 mg of the drug in the evening, on the eve of surgery.

For patients with renal failure (Cl creatinine is less than 50 ml / min), it is recommended to drink 150 mg of medication per day.

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Use Ranisan during pregnancy

When pregnancy, take the medicine is contraindicated.

Contraindications

Among the contraindications:

• the period of breastfeeding;
• children under the age of 12;
• individual intolerance to ranitidine and other components of the drug;
• malignization of peptic ulcer.

Side effects Ranisan

Taking drugs can provoke such adverse reactions: dizziness with headaches, diarrhea, depression, allergies, exanthema, and a temporary increase in the level of serum transaminases in the liver.

There are individual reactions such as cutaneous erythema, bradycardia, angioedema, reversible form of leuko- and thrombocytopenia, and besides this hypotension.

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Interactions with other drugs

Ranisan in combination with phenoxymethylpenicillin reduces the rate of absorption of the latter.

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Storage conditions

Keep the medication under standard conditions - in a place that is closed from moisture, sun rays and children's access. The temperature regime is within 15-25 ° C.

Shelf life

Ranisan is allowed to be used within 3 years from the date of manufacture of the medicinal product.