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Ramimed
Last reviewed: 03.07.2025
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Ramimed is a cardiovascular drug aimed at regulating blood pressure. It belongs to the drugs that affect the renin-angiotensin system.
Produced by pharmaceutical companies Actavis Ltd and Medochemie Ltd.
Ramimed is a prescription drug, so you should definitely consult a doctor before taking it.
Release form
Ramimed is produced in tablet form of 1.25 mg, 2.5 mg, 5 mg and 10 mg, 30 pieces per package.
Each tablet contains the active ingredient ramipril, as well as additional substances: pregelatinized starch, sodium bicarbonate, lactose, sodium croscarmellose, sodium stearyl fumarate, gelatin with dyes.
Pharmacodynamics
A blood pressure stabilizing agent that inhibits ACE. The active component of the drug is able to inhibit the action of ACE, due to which the vascular lumen expands and pressure readings decrease. ACE inhibition stimulates renin activity in the bloodstream, reduces the amount of angiotensin II and aldosterone. The action aimed at reducing pressure is observed at high and low levels of renin in the bloodstream. The active component has the property of inhibiting metabolic processes involving bradykinin.
A decrease in pressure is observed 1-2 hours after taking a dose of the drug. The maximum effect is observed after 3-6 hours and lasts for about a day.
The maximum therapeutic effect with regular use is established after 21-30 days. It has been proven that the pressure stabilizing effect can be maintained with long-term treatment for 2 years.
Abrupt discontinuation of Ramimed does not lead to an immediate and sudden increase in blood pressure readings.
Pharmacokinetics
After oral administration, the active ingredient is well absorbed in the digestive tract: the peak amount of the drug in the blood is detected within the first hour. The average degree of absorption is determined to be 56%, and this figure remains unchanged even in the presence of food masses in the stomach. The maximum amount of the active ingredient in the plasma is observed approximately 3 hours after taking the drug. With a standard dosage (once a day), the equilibrium of the drug can be achieved on the 4th day of therapy.
The active component binds to plasma proteins by 73%.
The drug is eliminated mainly through the urinary system. The half-life is 13 to 17 hours at a dosage of 0.005-0.01 g, or more at a dosage of 0.00125 g-0.0025 g. This is due to the saturation of the enzyme enzyme in relation to the binding of the active ingredient of the drug.
When Ramimed was used once, the active ingredient was not detected in breast milk. The degree of penetration into milk with regular use of tablets has not been studied.
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Dosing and administration
The drug Ramimed is taken daily at equal intervals. The tablet is swallowed whole, without crushing or chewing, with a sufficient amount of liquid. Simultaneous consumption of food does not affect the absorption of the drug: for this reason, the use of tablets may not depend on the time of food intake.
In some cases, it is permissible to split the tablet into two parts.
For the treatment of hypertension, the dosage is selected individually, and Ramimed can be prescribed as an independent drug or in combination with other antihypertensive drugs. The standard initial dosage involves taking 0.0025 g once a day. If necessary, the dosage is increased, doubling it once every 14-28 days. As an alternative, additional prescription of diuretics and calcium channel blockers can be used.
The standard maintenance dosage is 0.0025 to 0.005 g per day.
The maximum daily dosage is 0.01 g.
When treating heart failure, it is recommended to take 1.25 mg once a day. If the doctor prescribes a dosage of more than 2.5 mg, it is divided into two doses.
When treating a post-infarction condition, Ramimed is started two days after the infarction. Initially, 2.5 mg of the drug is taken twice a day. After three days, the dosage can be changed. The maximum daily dosage is 10 mg (0.01 g), taken in two doses.
To prevent the development of a heart attack or stroke, start with taking 2.5 mg of the drug once a day. Then the dosage can be revised upwards. Usually the dosage is doubled after 7-14 days of therapy, and after 14-20 days a maintenance amount of the drug is prescribed - 10 mg (0.01 g) once a day.
For elderly patients, treatment begins with a low dosage of 1.25 mg per day. The dosage is then adjusted, taking into account the possible development of side effects.
Use Ramimed during pregnancy
The use of Ramimed during pregnancy is not recommended due to the lack of reliable information about the effect of the drug on fetal development and the course of the gestation process.
If it is necessary to take the drug during breastfeeding, lactation should be temporarily stopped.
Contraindications
Contraindications to the use of Ramimed may be:
- hypersensitivity to the active component of the drug, or to other ACE inhibitors;
- history of Quincke's edema;
- arterial narrowing in one or both kidneys;
- complicated renal failure or dysfunction;
- primary hyperaldosterone production;
- pregnancy and breastfeeding;
- childhood;
- tendency to low blood pressure;
- instability of hemodynamic parameters.
Side effects Ramimed
Side effects of Ramimed are not uncommon. They may manifest themselves in the following symptoms:
- increase in antinuclear factor, anaphylaxis;
- signs of arterial collapse, hypotonic syncope, myocardial ischemia, cardiac arrhythmia, swelling of the extremities, decreased perfusion pressure, inflammation and vascular spasms;
- blood tests show signs of eosinophilia, neutropenia, agranulocytosis, decreased hemoglobin and platelet levels;
- headaches, changes in sensitivity of the extremities, dizziness, vestibular disorders, psychomotor disorders;
- mood instability, anxiety, sleep disorders, irritability;
- loss of visual acuity, inflammation of the conjunctiva;
- decreased hearing function, tinnitus;
- dry cough, sinusitis, bronchospasm;
- inflammatory processes of the mucous membranes of the mouth and digestive tract, dyspeptic disorders, pancreatitis;
- changes in taste sensations;
- hyperkalemia, loss of appetite, weight loss;
- increased liver enzymes, cholestasis;
- signs of acute renal failure, increased diuresis, increased levels of urea and creatinine in the blood;
- erectile dysfunction, decreased sexual activity, imbalance of sex hormones;
- allergic symptoms, excessive sweating, dermatitis;
- muscle pain and spasms, joint pain;
- chest pain, feeling tired.
Overdose
Symptoms of an overdose of Ramimed most often manifest in excessive dilation and relaxation of peripheral vessels, which can be expressed in the following symptoms:
- hypotensive state, up to arterial collapse;
- slowing of heart rate;
- electrolyte metabolism disorders;
- kidney dysfunction.
The overdose condition requires constant medical supervision. Symptomatic and supportive therapy is used: it is important to wash the stomach in a timely manner, prescribe sorbents (activated carbon, sorbex), and means for normalizing hemodynamics. Hemodialysis is ineffective in this case.
Interactions with other drugs
The combined use of antihypertensive, diuretic, opiate, anesthetic, tricyclic and antipsychotic medications may lead to increased hypotensive action.
Combined use with non-steroidal anti-inflammatory drugs (aspirin, indomethacin), estrogen-containing drugs, sympathomimetics and salt-containing drugs and products may lead to a decrease in the hypotensive effect.
Combined administration with potassium-containing drugs may lead to a significant increase in the level of potassium in the blood serum.
It is not recommended to take Ramimed with lithium-containing drugs: this may increase the toxic effects of lithium.
If combined therapy is carried out with the use of antidiabetic drugs (including insulin), this may provoke an increase in the hypoglycemic effect.
Combined use with cytostatics, immunosuppressants, and corticosteroids increases the risk of developing leukopenia.
Ramimed enhances the effects of alcohol.
Attention!
To simplify the perception of information, this instruction for use of the drug "Ramimed" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.