Radicold Plus

Radicold Plus is a medicinal product that is designed to withstand the first symptoms of influenza or any other colds. Carefully selected by the experts of the pharmaceutical company "Elegant India", the optimal balance of active components in their combined effect ensures high efficiency of using this medication from the very first days of the beginning cold. This in turn is a factor contributing to a reduction in the likelihood and prevention of the occurrence of all sorts of severe consequences and complications of the disease.

Indications Radicold Plus

Indications for use Radicold plus suggest its use for symptomatic treatment of acute inflammatory processes in the upper respiratory tract such as sinusitis, tracheitis, pharyngitis.

It is also justified to prescribe the drug in case of allergic diseases to which the upper respiratory tract is exposed.

In addition, this antipyretic and analgesic drug is included in the list of treatments against influenza, other colds and acute respiratory viral infections, which are accompanied by a runny nose, a feeling of nasal congestion and headaches.

Radicold plus also finds its application in the treatment of various kinds of inflammation developing in the paranasal sinuses.

Thus, the indications for the use of Radicold Plus are mainly conditioned by its expediency for reducing the severity of the symptoms of the beginning flu, cold, SARS. The drug in the case of timely start of its use in the early stages of the development of colds, promotes the course of the disease in mild form, recovery of the patient in the shortest time and avoidance of complications.

Release form

The form of Radicold Plus is presented in the form of tablets. Tablets have a round flat shape, have bevels and incisions, applied on one side. Their color is pink, but can vary to a pale pink hue.

Each tablet contains 300 mg of paracetamol, chlorpheniramine maleate, phenylephrine hydrochloride, caffeine - 2 mg, 5 mg and 16 mg of each of these ingredients, respectively.

In addition to the main active ingredients listed, there are a number of other excipients: povidone, corn starch, colloidal silicon dioxide, magnesium stearate, purified talc, sodium starch glycolate and sodium benzoate. In addition, there is the presence of the dye Eritosin Supra.

Pharmacodynamics

The combination of ingredients, formed by paracetamol, phenylpropanolamine and chlorpheniramine maleate, updates its best properties in the symptomatic treatment of colds and influenza.

Paracetamol has its effect in that area of the hypothalamus, which is responsible for heat exchange in the body, in a way that causes vasodilation and stimulates sweating, which provides better heat dissipation.

Due to the content of phenylpropanolamine hydrochloride in this combined preparation, it helps to cope with such a phenomenon as nasal congestion accompanying influenza and other acute respiratory viral infections. This active component produces an indirect adrenomimetic effect on the vascular endothelium in the nasal mucosa. Having an effect similar to ephedrine, it has such an advantage in comparison with the latter as that which at least leads to stimulation of the central nervous system.

Due to the administration of this drug, mild cough is suppressed by the action of chlorpheniramine maleate, which is blocked by H1-histamine receptors. Since histamine is involved in the inflammation of the mucous membranes, when the latter are competitively related, the symptoms of influenza and acute respiratory viral infection caused by it become less pronounced.

The inclusion of caffeine in the sucker of this drug allows the patient to get rid of lethargy, contributes to the fact that his motor activity increases, and the intensity of the headache decreases. And as a result - the patient's performance improves. In addition, there is evidence that caffeine can lead to increased antipyretic and analgesic effects of paracetamol.

Pharmacodynamics Radicold Plus is manifested as the combined pharmacological action of the main active components of the drug.

Paracetamol refers to the derivatives of para-aminophenol, and produces a pronounced analgesic effect, and in addition contributes to the reduction of elevated body temperature for colds, flu and acute respiratory viral infections of the upper respiratory tract. The effect of paracetamol is to inhibit the processes in which prostaglandins are synthesized, and in addition it helps to reduce the excitability of the thermoregulatory center in the hypothalamus. In addition, paracetamol blocks cyclooxygenase I, II in the central nervous system.

Chlorpheniramine maleate, under the action of which the H1 receptors are blocked, is actualized in its M-holiblocking, sedative and antiallergic effect. Thanks to it, the degree of severity of lachrymation and rhinorrhea, pruritus in the nose and eyes, and moderate bronchol- otic action are reduced.

As a result of the pharmacological action of phenylephrine hydrochloride in the mucous membrane in the nasal cavity and in the paranasal sinuses, hyperemia decreases, and edema collapses.

Strengthening the analgesic effect Radicold Plus ensures the presence of caffeine in its components. This ingredient also has a stimulating effect on the central nervous system of the patient.

So, the pharmacodynamics of Radicalold plus is a complex antipyretic and analgesic action of the drug.

Pharmacokinetics

As well as the pharmacological features of the drug, the pharmacokinetics of Radicalold Plus is characterized by the pharmacokinetics properties of each of the active active ingredients that make up its composition.

Regarding, first of all, the main one of them - paracetamol, it should be noted that in the upper part of the gastrointestinal tract there is almost complete (in 95% amount) its absorption for a very short time. The maximum concentration in the blood plasma, he forms for a period of 15 to 120 minutes. After metabolization in the liver, paracetamol is excreted from the body primarily by the kidneys.

The absorption of chlorpheniramine in the intestine requires a longer time than paracetamol, and it occurs to a degree equal to 80%. Its concentration in the blood plasma comes to the maximum values after the expiration of 2 and a half to 6 hours. Chlorpheniramine binds to blood plasma proteins by 45%. It is excreted mainly in the urine. The half-life is 30 hours.

Phenylephrine shows indicators indicating its easy absorption in the gastrointestinal tract. The concentration in the blood plasma reaches peak values in 60-120 minutes. Leaves the human body in the unchanged form with urine, as well as the metabolites present in it.

What should be said about caffeine is that this component of the drug is characterized by high rates of absorption in the gastrointestinal tract and spreading through the tissues of the body, forming a maximum concentration in the blood plasma from less than 1 hour to 75 minutes. The binding in blood plasma with proteins takes place in an amount of approximately 17%. Half-life occurs for 5-10 hours. Caffeine along with its metabolites eventually falls into the urine and leaves the body mostly with it.

Dosing and administration

Dosage and Administration Radicold Plus regulates the administration of this medication as follows.

For adults and children who have reached the age of 12 years, the recommended dose is 1-tablet 3 times-four times a day. Tablets should be swallowed whole, without breaking or chopping them, using for drinking the necessary sufficient amount of water.

The course of treatment with the drug should not be longer than the first week.

Use Radicold Plus during pregnancy

It is not recommended to use Radicold plus during pregnancy, and also during lactation breastfeeding.

Contraindications

Contraindications to the use of Radicold Plus may be caused by the existence in a particular patient of an individual hypersensitivity to any of the components making up this complex drug. In addition, this medication is incompatible with a number of different diseases.

These include: coronary heart disease and hypertension in severe forms, the presence of bradycardia and gastric tachycardia. Radicold Plus is not prescribed if the patient has hepatitis, acute pancreatitis, prostatic hypertrophy.

Unjustified is the use of the drug in cases of severe violations of the liver, as well as renal dysfunction.

Radicold plus is not used in relation to people suffering from alcoholism.

With regard to the period of pregnancy and subsequently, when the infant is breastfed - medical experts advise women to refrain from taking this medication.

It is also implied that it should not be used for children under 12 years of age.

There are also some cases that do not represent direct contraindications to the use of Radicold Plus, but require increased attention to the possibility of prescribing the drug. So in this regard, calls for caution closed-angle glaucoma, urinary retention, impaired motor skills and gastric obstruction in the patient, epilepsy and bronchial asthma.

Side effects Radicold Plus

Side effects Radicold Plus have as their main manifestations the emergence of nausea, vomiting, headaches, dizziness, the development of anorexia.

The result of the negative effect of the drug on the central nervous system of the patient becomes a state of increased excitability, excessive irritability, possible problems with sleep - insomnia.

Cardiovascular and circulatory system for the use of this drug give its unfavorable response in the form of high blood pressure, heart pain, the development of arrhythmias, bradycardia and the appearance of thrombocytopenia.

On the part of the gastrointestinal tract, respiratory and other systems of the human body as a result of taking Radicold Plus, there is a decrease in intestinal tone and peristalsis, the appearance of colic in the liver, dry mucous membranes in the respiratory tract, vision may be impaired.

The use of the drug is associated with the possibility of an allergic reaction having the appearance of a rash on the skin.

Due to the fact that the side effects of Radicold Plus, with a certain unfavorable combination of factors, one way or another can take place, one must adhere to certain precautions when prescribing it. For example, the degree of risk is higher in the elderly patient and in patients who have a tendency to high blood pressure.

Overdose

The fact that there is an overdose of this medication is indicated by the appearance of the corresponding symptomatology.

Among the main symptoms caused by excessively overestimated doses of Radicalold plus belong: blurred skin, anorexia, abdominal pain, nausea, vomiting, dizziness and headache, ringing in the ears, hypertension, hyperesthesia, general weakness, tremors, heart rhythm disturbances , fever, cramps, the appearance of insomnia, or, on the contrary, excessive drowsiness.

Treatment should be carried out with the gastric lavage and the use of adsorbents - activated carbon. Therapeutic measures are symptomatic.

Overdose may also imply the need to use a specific antidote against intoxication from paracetamol - methiond, acetylcysteine.

Interactions with other drugs

When considering the interaction of Radicold Plus with other drugs, it should immediately be noted that it is not recommended to appoint it together with any of the other paracetamol-containing medications.

Under the influence of paracetamol, the effect of indirect anticoagulants is increased, and the risk that the liver will be affected by drugs with hepatotoxic properties - barbiturates, ethanol, rifampicin and phenytoin - increases.

The rates with which paracetamol is absorbed are influenced by cholestyramine and metoclopramide. While the former is a factor slowing down this process, the second, on the contrary, can reduce the time required for this.

Chloramphenicol in combination with paracetamol takes on a more pronounced toxic properties.

The content in Radicold plus caffeine causes a decrease in the effect produced by narcotic and hypnotic drugs when combined with this medication. On the other hand, with respect to paracetamol and acetylsalicylic acid, caffeine has exactly the opposite effect, which is to enhance their effect. It also contributes to the fact that ergotamine is better absorbed in the gastrointestinal tract.

Chlorpheniramine can lead to an increase in the sedative effect that is produced by central nervous system depressants - barbiturates, ethanol, hypnotics, tranquilizers, narcotic analgesics. Tricyclic antidepressants and atropine also show more pronounced effect on it.

Phenylephrine interacting with guanethidine, reserpine, methyldopa is able to demonstrate a stronger effect.

Interactions Radicold plus with other drugs, thus, are characterized by the features of the combined effect of the resulting in the combinations formed by each of its main component with other medications included with it in complex therapy.

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Storage conditions

RadiCold Plus storage conditions are required such that the external environment in which the drug is contained corresponds to a constant regime with a temperature not exceeding 25 degrees Celsius and with an extremely low humidity level. In addition, an important point is to protect this drug so that it can fall into the hands of children.

Shelf life

Shelf life Radicold Plus is declared by the manufacturer within 3 years from the time of preparation.