Rabimak

Rabimak is a drug that suppresses the production of hydrochloric acid in the stomach cavity. Let's consider the indications for use, dosage and possible side effects.

The drug is prescribed for the treatment of acid-dependent diseases, as it affects the metabolism and digestive system. The drug has antiulcer properties and is used to treat gastroesophageal reflux and peptic ulcers. Manufactured in India by MacLeods Pharmaceuticals Ltd.

Rabimak is available only with a doctor's prescription.

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Indications Rabimak

Indications for use of Rabimak are based on the pharmacological properties of proton pump inhibitors, which this drug belongs to. International name - rabeprazole. Tablets are prescribed for the treatment and prevention of diseases such as:

• Duodenal ulcer
• Zollinger-Ellison syndrome
• Helicobacter pуlоri eradication (in combination with other antibacterial agents)
• Stomach ulcer
• Non-ulcer dyspepsia
• Gastroesophageal reflux disease
• Chronic gastritis (in the acute stage).

Release form

Release form – film-coated tablets, enteric-coated. Main physical and chemical properties: tablets of yellow (10 mg) and red-brown (20 mg) color, round, with a notch on one side, biconvex. One package contains 2-3 strips in a cardboard package, each strip contains 7-10 tablets.

The active substance is rabeprazole. The following components are used as auxiliary ones: hydroxypropyl methylcellulose, magnesium oxide, methacrylic acid copolymer, hydroxypropyl cellulose, mannitol, magnesium stearate, iron oxide yellow (for 10 mg tablets), iron oxide red (for 20 mg tablets) and others.

Pharmacodynamics

Pharmacodynamics Rabimak is the mechanism of action of the active components. The drug belongs to the class of antisecretory compounds, has no anticholinergic properties and does not belong to the antagonists of the host H2 receptors. Inhibits the secretion of gastric acid by inhibiting the enzyme H + / K + -ATPase in the parietal cells of the stomach. This enzyme system belongs to proton pumps, so Rabimak is in this category. The active substance blocks the production of hydrochloric acid at the final stage and is transformed into an active sulfonamide form.

An antisecretory effect is observed 1-3 hours after administration, suppressing two functions of acid secretion. The effectiveness of suppression of secretion is enhanced by daily intake of 1 tablet, but a stable effect is achieved 3 days after the start of administration. After completion of the course of treatment, secretory activity is restored within 2-3 days.

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Pharmacokinetics

Pharmacokinetics Rabimak is the processes of absorption, metabolism and excretion. Since the tablets are covered with an enteric coating, they are quickly and completely absorbed in the intestine. The maximum concentration in the blood plasma occurs after 3-4 hours (at a dosage of 20 mg). Bioavailability when taken orally is about 52% due to first-pass metabolism. With repeated use of the drug, bioavailability does not increase.

The plasma half-life is 1-2 hours, and the total clearance is 283 ± 98 ml / min. Food intake does not affect the absorption process. Plasma protein binding is 97%. About 90% is excreted by the kidneys in the form of metabolites: thioether (M1) and carboxylic acid (M 6). The remaining 10% is excreted in feces.

Dosing and administration

The method of administration and dosage depend on the indications for use of the drug and the doctor's recommendations. For the treatment of gastric ulcer and peptic ulcer, patients are prescribed 20 mg once a day (if necessary, the dosage is increased to 40 mg, i.e. 20 mg in the morning and evening). The duration of treatment is from 2 to 8 weeks, with maintenance therapy up to 12 months.

For non-ulcer dyspepsia, 40 mg is used once a day for 2-3 weeks. For the eradication of H. pylori, a combination therapy regimen with effective antibiotics is used. Rabimak is taken 20 mg twice a day with other drugs. For the treatment of Zollinger-Ellison syndrome, a dosage of 20 to 120 mg per day can be used, the course of treatment is 2-8 weeks. Chronic gastritis is treated with 40 mg once a day for 2-4 weeks. It is not recommended to chew or crush the tablets, take them in the morning before meals.

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Use Rabimak during pregnancy

The safety of Rabimak during pregnancy has not been confirmed. According to experiments, the drug can penetrate the placental barrier, so it is not recommended for use in the treatment of expectant mothers. Rabeprazole can penetrate into breast milk, so when using it, it is necessary to stop the lactation process.

According to the drug's side effect profile, it is not recommended to use it when working with potentially dangerous machinery or when driving vehicles. If the tablets cause increased drowsiness or dermatological manifestations, you should stop taking them and consult a doctor to select an analog drug with a safer mechanism of action.

Contraindications

Contraindications for the use of Rabimak are individual intolerance to the active substance - rabeprazole or other components of the drug. Tablets are not used in case of hypersensitivity to substituted benzimidazoles.

Pregnancy and lactation are also contraindications to the use of the drug. The drug is not prescribed to children, since there is no reliable information about its safety for patients of this age group.

Side effects Rabimak

Side effects of Rabimak are rare, as the drug is well tolerated. If this occurs, it has minor, that is, moderate symptoms. More often, side effects appear from the digestive system - these are abdominal pain, flatulence, nausea and vomiting, belching, diarrhea or constipation. In rare cases, dry mouth, stomatitis, taste disturbances and increased activity of liver enzymes are possible.

In some cases, disorders of the hematopoietic system are possible, i.e. thrombocytopenia and leukopenia. Patients may experience symptoms such as headaches and dizziness, drowsiness, depression and agitation. In rare cases, allergic reactions occur, i.e. skin itching, rash, bronchospasms or angioedema. Other side effects: back and chest pain, calf muscle cramps, urinary tract infections, pharyngitis, flu-like syndrome.

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Overdose

Overdose occurs when the doctor's recommendations for use of the drug are not followed. Most often, these are headaches, drowsiness, nausea and vomiting, dizziness, dry mouth and increased sweating. There is no specific antidote, so symptomatic therapy and supportive care are used to eliminate the overdose.

To avoid side effects, before starting to take the drug, it is necessary to exclude the presence of malignant neoplasms of the gastrointestinal tract. If the tablets are prescribed to patients with severe liver and kidney dysfunction, then medical supervision is required in the early stages of therapy.

Interactions with other drugs

Rabimac interactions with other drugs are possible if the absorption of other drugs depends on the pH of the gastric contents. This is due to the fact that rabeprazole is metabolized by enzymes (cytochrome P-450 system (CYP450)), like other proton pump inhibitors, causes a long-term decrease in the production of hydrochloric acid.

The drug causes a significant decrease in the concentration of ketoconazole and an increase in the concentration of digoxin. Therefore, patients using these drugs simultaneously with Rabimac need to be monitored by a doctor for timely dosage adjustment.

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Storage conditions

Storage conditions for Rabimak are specified in the instructions for the medicinal product. The medicine should be kept in a dry place, protected from direct sunlight and out of reach of children. The recommended storage temperature is 25 °C.

If storage rules are not followed, the drug may change its physical and chemical properties. In this case, the drug is prohibited from being taken and must be disposed of.

Shelf life

The expiration date is 24 months from the date of manufacture. After this period, the medicine should be thrown away. Since the use of an expired drug can lead to uncontrolled side effects.