R-CIN should be used strictly according to the doctor's prescription, in the dosage prescribed by him. Self-medication is unacceptable, since an uncontrolled or improperly selected regimen of Rifampicin may cause dangerous complications in the patient.
Dosage and administration: the drug is administered inside (in the form of capsules and tablets), and also administered intravenously (drip).
Tablets or capsules are taken on an empty stomach half an hour before meals or 2 hours after meals. In the treatment of tuberculosis patients, the daily dosage of Rifampicin ranges from 450 to 600 mg for adults (taking into account the patient's body weight), for newborns and small children from 10 to 20 mg / kg. When detecting the carriage of meningococci, the dose for adults is a maximum of 600 mg per day (duration of admission is 4 days).
In the process of treatment of tuberculosis, R-CIN is usually combined with some anti-tuberculosis drug: in particular, Etambutol, Pyrazinamide Isoniazid, and others.
With pulmonary tuberculosis, the therapy period is usually 6 months; in the treatment of disseminated tuberculosis or tuberculosis meningitis, as well as the complication of tuberculosis with HIV infection, the duration of treatment with Rifampicin is 9 months. In each case, the doctor appoints the patient a separate treatment regimen. In case of exacerbation of the disease and ineffectiveness of therapeutic treatment, antituberculous drugs should be taken in a hospital strictly under the supervision of medical personnel.
When treating leprosy:
- multibacillary types: for adults - 600 mg of the drug once a month (together with drugs Dapson and Clofazimine); for children - 10 mg / kg (plus Dapsone); period of therapy - 2 years;
- pausibacillary types: for adults - 600 mg of the drug once a day (together with Dapson); for children - 10 mg / kg once a month (together with Dapson); period of treatment - 6 months.
When treating R-CIN infectious diseases, the development of which is provoked by sensitive microorganisms, the antibiotic is administered together with other antimicrobial drugs. In this case, the daily dose of Rifampicin is: from 0.6 to 1.2 g to adults; from 10 to 20 mg / kg - for children and newborns. The drug is taken twice a day.
In the treatment of brucellosis, adults are prescribed 900 mg / day of R-CIN once, preferably in the morning on an empty stomach; while the drug is combined with Doxycycline. The duration of the therapy period is 45 days.
In order to prevent the disease with meningococcal meningitis, R-CIN is prescribed twice a day every 12 hours: 600 mg to adults; 10 mg / kg for children; 5 mg / kg - to the newborn for 1 reception.
Intravenous (with the aid of a dropper) Rifampicin is prescribed in some cases: in the presence of destructive tuberculosis, the development of serious purulent-septic processes, and to create a high concentration of antibiotic in the blood in order to quickly suppress the focus of infection; if the medication is difficult or difficult to tolerate.
The duration of intravenous treatment with P-CIN depends on the total tolerability of the drug and is approximately one month or more with a further transition to the use of the drug in tablet form.
When treating various non-tuberculosis infections, the dose of antibiotic is 0.3-0.9 g, maximum - 1.2 g per day. The duration of therapy is determined by the doctor individually, taking into account the effectiveness of the drug, and is approximately 7 to 10 days.
Patients taking R-CIN should consider the possibility of dyeing the skin, urine, tear fluid, sputum, and soft contact lenses in an orange-red hue under the influence of the drug.