Polysorb in psoriasis

Psoriasis (scaly lichen) is a chronic dermatological pathology of noninfectious genesis. It is characterized by the appearance of patches typical for this disease, towering above the surface of the skin, peeling pink-red. The reasons for which pathology occurs are still not found. There are scientific hypotheses about the nature of genesis: autoimmune, genetic, endocrine, metabolic, violation of normal neurohumoral reactions, due to stress. The appearance of the first manifestations of scaly lichens occurs at the age of 15-30 years. There are many scientifically developed classifications of psoriasis.

Typical rashes are combined into groups to localize the manifestations on the skin, the degree of prevalence, the severity of the general condition of the patient, the specific features of the rashes and their pathological properties. The provoking factors are: stressful states of the immune system, a psychogenic cause of pathology and heredity. The most common symptoms of psoriatic manifestations are: the appearance of the depolarized dense papules prone to fusion and covered with whitish or grayish readily removable scales. Psoriasis spots rise above the surface of the skin, causing itching and scratching. With minor injuries on the surface of the rashes appears "bloody dew". The most typical spread of localizations of psoriatic manifestations is the skin on the extensor surfaces of large joints, the scalp, parts of the body subjected to friction.

The course of systemic disease is undulating with remissions, during which complete disposal of the characteristic dermatological manifestations does not occur. It is impossible to completely cure squamous lichen, but to reduce and alleviate its manifestations is one of the goals of modern medicine. Given the mechanism of the appearance of psoriatic manifestations, the body accumulates a sufficiently large number of toxins. Their removal plays an important role in reducing the manifestations of psoriasis.

[1], [2], [3]

Indications Polysorb in psoriasis

Treatment of psoriasis, which refers to dermatoses, is complicated by the lack of balance between the accumulation and excretion of toxic substances from the body. Skin is a complex multifunctional system. Any toxic effects, both internal and external, can lead to pathological changes in it. In order to detoxify the body, the Polysorb preparation is used. The main indications for the use of the drug:

• intoxication (acute or chronic) of both adult and children's organisms, regardless of its cause;
• intestinal infections triggered by various microorganisms;
• food poisoning;
• Intestinal dysbiosis;
• drug allergization;
• severe intoxication in purulent-septic contingencies;
• acute poisoning with chemicals;
• chronic or acute sensitization (various types of allergic reactions);
• Complex therapy of hepatitis, pancreatic gland, renal failure (included in the treatment scheme).

Prevention of the accumulation of hazardous chemicals for health in people living in areas with poor ecology.

[4], [5], [6]

Release form

Active active substance - silicon dioxide (SiO ₂ ). Auxiliary ingredients do not contain. Only Polysorb powder form is available. Powder of a snow-white color with a light bluish tint, odorless.

A suspension for oral administration is prepared from the preparation. The drug is sold by the pharmacy network in plastic bottles, the volume of which is -12, 25, 50 g, as well as packages of 1 g or 3 g.

[7], [8]

Pharmacodynamics

Polysorb is an active enterosorbent with antacid properties. It has an absorbing effect. It adsorbs and evacuates harmful substances of exogenous and endogenous nature (allergens, endotoxins of bacterial and viral origin, toxic metabolites of lipid and protein breakdown formed in the intestine). It facilitates the removal and transportation from the systemic bloodstream into the intestinal lumen of poisonous toxic compounds, amines, oligopeptides. In the intestine, they are bound to the sorbent and evacuated from the body.

[9]

Pharmacokinetics

Polysorb is not able to be absorbed or digested by the digestive tract. Outwardly excreted in feces unchanged. The sorption surface is 300 m ² / g. Acts instantly (after 2-4 minutes) getting into the digestive tract.

[10]

Dosing and administration

Prepare the colloidal solution as follows: 1 cup of st. L. Is added to a glass of cool boiled water. (1.2 g) Polysorb to adults or 1 tsp. (0.6 g) of the drug to children. The solution must be thoroughly mixed until a uniform suspension is obtained. Use it orally immediately after preparation. It is necessary to observe time intervals that take into account the diet or taking medications. Polysorb used for 60 minutes. Up to or 1.5-2 hours after taking food or applying medication.

Adults and children over the age of 7 years are prescribed 12 g of Polysorb per day; children from 1 year to 7 years - 150-200 mg / kg of the weight of the child. The daily dose of the drug is divided into 3-4 doses. A single maximum allowable amount of a sorbent should not exceed half the daily dose.

The duration of the course of polysorb for psoriasis is 14-21 days.

For prevention and complex therapy of allergic sensitization, adults are prescribed 1-2 tsp. Three times a day before meals.

[16],

Use Polysorb in psoriasis during pregnancy

The periods of pregnancy and lactation are not contraindications to the reception of Polysorb. The drug does not have a teratogenic effect and does not harm the health of the mother. In the gestational period, long courses of application of enterosorbent are prohibited. Long-term use of Polysorb (more than two weeks) requires additional intake of vitamin complexes and calcium preparations, since this sorbent can slightly reduce the level of their content in the mothers and the future child. For competent selection of mineral-vitamin complexes, specialist consultation is required. During the period of taking the drug, there may be a tendency to constipation. With the preventive purpose it is required to enrich the diet with products rich in fiber.

Contraindications

• hypersensitivity to the active ingredient of the drug;
• children under 1 year;
• stomach and / or duodenal ulcers;
• erosion of the intestine;
• atony of the intestine.

[11], [12]

Side effects Polysorb in psoriasis

Virtually absent. There may be difficulties in evacuation of the intestine (constipation), dyspeptic phenomena. When allergic reactions occur, which is extremely rare, the drug should be discontinued. Long-term courses of reception of Polisorba in psoriasis require the appointment of mineral-vitamin complexes and preparations containing calcium, as the enterosorbent slightly reduces the levels of their content in the systemic bloodstream of the body.

[13], [14], [15]

Overdose

Data on cases of overdose are absent.

[17], [18], [19], [20], [21]

Interactions with other drugs

Simultaneous use of Polysorb with various drugs can reduce their therapeutic effectiveness.

[22], [23], [24]

Storage conditions

To be stored in tightly closed containers, in a dark, dry place with an air temperature of not more than 25 ° C.

[25], [26]

Shelf life

The date of manufacture and the expiry date of the drug are indicated on the factory carton and plastic bottle. According to the instructions the storage time is 5 years. It is not recommended to use after the expiration date. The ready-made suspension can be stored for 48 hours in the refrigerator.

[27], [28]

Reviews of doctors and patients

Polisorb natural, without chemical preservatives and stabilizers, drug. Well tolerated by patients. Has a positive effect in the treatment of dermatological diseases such as psoriasis, atopic dermatitis, toxicodermia. A constant, concomitant of these diseases, a symptom is a general endointoxication. Endotoxins lead to insensitivity of the body to many medicines.

Doctors who conducted studies on the use of enterosorbents in the complex therapy of various systemic diseases noted that Polysorb can increase the susceptibility of the body to drug treatment. The use of polysorb in psoriasis as a detoxification method of therapy was successful in arresting dermatological manifestations of food and drug allergies and reducing psoriatic eruptions.

Only complex treatment of dermatological diseases has a positive effect. According to medical research, treatment of psoriasis with short courses of fasting, the use of Polysorb, antioxidants (Vitamin A and E), ointments for external use, UV irradiation and lotions with decoction of celandine gave positive dynamics. Half of the patients had almost complete recovery, and a quarter of those who participated in the experiment had a significant improvement in skin condition.

The patients themselves note that in complex treatment of psoriasis with the help of specific preparations and enterosorbent Polisorba they significantly decreased skin itching, repeated appearance of rashes, and reduced areas of lesions.

Negative feedback on the use of enterosorbents Polysorb in psoriasis is left by people who, due to the peculiarities of their body, find it difficult to take the drug. Patients are uncomfortable with its consistency and taste, or they are intolerant of this remedy. In their responses, they indicate that their negative is associated only with subjective sensations.

Objectively, most of the responses, both doctors and patients, indicate that the use of enterosorbent Polysorb as a component of complex treatment for psoriasis gives positive results. Therefore, it can be used in standard therapy of dermatological diseases of any genesis.