Phenylline

Phenylline has an anticoagulant effect on the body.

[1], [2], [3], [4], [5], [6]

Indications of the phenylline

The medicine is used in the therapy or prevention of such diseases:

• thrombosis with thrombophlebitis and complications of thromboembolic character (provoked by myocardial infarction), and in addition strokes of the embolic type and similar disorders;
• to prevent the formation of thrombi after performing surgical operations.

[7], [8], [9], [10]

Release form

The release occurs in tablets, in quantities of 20 or 50 pieces inside the box.

[11], [12], [13], [14]

Pharmacodynamics

The use of the drug affects the blood circulation. The drug is an indirect anticoagulant. The use of phenilin leads to the development of hypoprothrombinemia, which is due to the disorder of the processes of prothrombin formation inside the liver, and in addition to reducing the formation of factors such as 7, 9 and 10.

Along with this, the drug has a more powerful cumulative effect than the neodicumarin element. For 8-10 hours after oral administration, the values of the blood turnover factors decrease, and to achieve peak values, 24-30 hours are necessary.

[15], [16], [17], [18]

Pharmacokinetics

The drug is completely and quickly absorbed after application. The active element passes through the histohematic barrier, cumulating inside the tissues.

Metabolic processes are carried out in the liver.

Excretion occurs through the kidneys - in the form of unchanged substance, as well as metabolic products.

[19], [20], [21], [22], [23], [24],

Dosing and administration

Take the pill orally. It should be borne in mind that the treatment scheme will have some peculiarities, because of what the drug should be taken solely in accordance with medical prescriptions. The size of the initial daily dose is often 0.12-0.18 g, which should be taken for 3-4 times. Next, the next day, the size of the portion should be reduced to 0.09-0.15 g, and even later - to 0.03-0.06 g. In the future, the frequency of reception and the size of doses are determined by the values of prothrombin inside the blood.

For 1 reception, you can take no more than 0.05 g of the drug, and for the whole day - a maximum of 0.2 g.

To prevent the occurrence of complications of thromboembolic character, you should use 0.03 g of LS 1-2 times / day.

When treating acute thrombosis, it is necessary to take the drug together with heparin. The therapy should be under strict doctor supervision. Obligatory is also the constant monitoring of the prothrombin indices inside the blood, as well as other factors of blood circulation. Terminate the therapeutic course should be gradual.

[31], [32], [33]

Use of the phenylline during pregnancy

It is forbidden to prescribe Phenylline in the early stages of pregnancy.

Contraindications

The main contraindications:

• baseline prothrombin counts of less than 70%;
• hemorrhagic form of diathesis and other diseases that develop due to the weakening of blood circulation;
• problems with kidney and liver;
• increased vascular permeability;
• presence of malignant tumors;
• ulcers in the gastrointestinal tract;
• pericarditis.

In addition, it is forbidden to take Phenylline in the first few days after the birth, as well as during menstruation.

[25], [26], [27], [28], [29]

Side effects of the phenylline

In the course of therapy, there may appear such side effects as nausea, allergy symptoms, hepatitis and diarrhea. In addition, there are violations of hematopoiesis, headaches and fever. You can also expect a change in the shade of urine and skin.

[30]

Overdose

When poisoning, there may be an exacerbation of adverse manifestations of drugs. The main antagonist of the drug is vitamin K.

To remove violations, you should immediately cancel the drug, and immediately enter the victim v / m method Vikasol. In addition, appoint rutin, calcium chloride and ascorbic acid (or perform other symptomatic procedures).

[34], [35], [36], [37]

Interactions with other drugs

Combination of a medicament with salicylates, heparin, cimetidine or sulfonamides can potentiate their anticoagulant effect.

At the same time, agents such as allopurinol and azathioprine with amiodarone and anabolic drugs can potentiate the properties of Phenylin itself, and in addition antibiotics, opiates, tricyclics with androgens, disopyramide with GCS, isoniazid with clofibrate and butadione. This group also includes metronidazole with diazoxide, paracetamol and quinidine with reserpine and α-tocopherol, and in addition disulfiram with cyclophosphamide and thyroid hormones.

Essentially reduce the effect of fenindione can ascorbic acid, propranolol with rifampicin, vitamin K and phenazone, antacids with barbiturates, diuretics, haloperidol with oral contraception, meprotan with carbamazepine and colestyramine, and drugs that alkalinize the urine.

[38], [39]

Storage conditions

Phenylline is required to be kept in a dry and dark place, where there is no access for young children.

[40], [41], [42]

Shelf life

Phenylline is allowed to be used for 3 years after the release of the drug.

[43], [44]

Reviews

Phenylline is considered one of the most effective drugs with a similar type of pharmacological action - it acts qualitatively with the improvement of the blood state. This fact is noted in many medical forums.

Therapy with this drug helps most patients to restore normal levels of blood loss. Along with this, literally after the lapse of 7 days of the course, the patient has general improvements, convulsions, and numbness in the legs. Although some patients experience an increase in nosebleeds, doctors believe that such changes during the therapy period are completely normal. Often, at the end of the course, this violation completely passes.

In addition to discussing the impact and effectiveness of drugs, among the patients' reviews, one can often find reports that Fenilin is often exposed to fakes, and therefore, when buying it, one must be extremely careful not to get a fake. That is why it is recommended to buy medicines exclusively in pharmacies that have reliable recommendations.