Phenylline

Phenylin has an anticoagulant effect on the body.

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Indications Fenilina

The medicine is used in the treatment or prevention of the following diseases:

• thrombosis with thrombophlebitis and thromboembolic complications (provoked by myocardial infarction), as well as embolic strokes and similar disorders;
• to prevent the formation of blood clots after surgical operations.

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Release form

The product is released in tablets, in quantities of 20 or 50 pieces per box.

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Pharmacodynamics

The use of the drug affects blood coagulation. The drug is an indirect anticoagulant. The use of Phenylin leads to the development of hypoprothrombinemia, which is caused by a disorder in the processes of prothrombin formation inside the liver, and in addition to this, to a decrease in the formation of factors of type 7, 9 and 10.

At the same time, the drug has a more powerful cumulative effect compared to the element neodicumarin. Within 8-10 hours after oral administration, the values of blood coagulation factors decrease, and 24-30 hours are required to achieve peak values.

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Pharmacokinetics

The medicine is completely and quickly absorbed after application. The active element passes through the histohematic barrier, accumulating inside the tissues.

Metabolic processes take place in the liver.

Excretion occurs through the kidneys - in the form of unchanged substance, as well as metabolic products.

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Dosing and administration

The tablets must be taken orally. It should be taken into account that the treatment regimen will have some peculiarities, which is why the drug should be used only in accordance with the doctor's prescriptions. The size of the initial daily portion is often 0.12-0.18 g, which should be taken in 3-4 doses. Then, the next day, the portion size should be reduced to 0.09-0.15 g, and even later - to 0.03-0.06 g. In the future, the frequency of administration and the size of the doses are determined by the values of prothrombin in the blood.

You can take no more than 0.05 g of the drug at one time, and a maximum of 0.2 g per day.

To prevent the occurrence of thromboembolic complications, 0.03 g of the drug should be taken 1-2 times a day.

When treating acute thrombosis, it is necessary to take the drug together with heparin. Therapy should be carried out under strict supervision of a doctor. Constant monitoring of prothrombin levels in the blood, as well as other factors of blood coagulability, is also mandatory. The therapeutic course should be discontinued gradually.

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Use Fenilina during pregnancy

It is prohibited to prescribe Phenylin in early pregnancy.

Contraindications

Main contraindications:

• initial prothrombin levels less than 70%;
• hemorrhagic form of diathesis and other diseases that develop due to weakened blood clotting;
• problems with kidney and liver function;
• increased vascular permeability;
• the presence of malignant tumors;
• ulcers in the gastrointestinal tract;
• pericarditis.

In addition, it is prohibited to take Phenylin in the first few days after birth, as well as during menstruation.

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Side effects Fenilina

During the therapy, side effects such as nausea, allergy symptoms, hepatitis and diarrhea may appear. In addition, there are disorders of hematopoiesis, headaches and fever. You can also expect changes in the shade of urine and skin.

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Overdose

In case of poisoning, the side effects of the drug may worsen. The main antagonist of the drug is vitamin type K.

To eliminate the violations, you should immediately stop taking the drug, and at the same time immediately administer Vikasol to the victim intramuscularly. In addition, rutin, calcium chloride and ascorbic acid are prescribed (or other symptomatic procedures are performed).

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Interactions with other drugs

Combining the drug with salicylates, heparin, cimetidine or sulfonamides may potentiate their anticoagulant effect.

At the same time, potentiation of the properties of Phenylin itself can be provided by such substances as allopurinol and azathioprine with amiodarone and anabolics, and in addition to this, antibiotics, opiates, tricyclics with androgens, disopyramide with GCS, isoniazid with clofibrate and butadion. This group also includes metronidazole with diazoxide, paracetamol and quinidine with reserpine and α-tocopherol, and in addition, disulfiram with cyclophosphamide and thyroid hormones.

Ascorbic acid, propranolol with rifampicin, vitamin K and phenazone, antacids with barbiturates, diuretics, haloperidol with oral contraception, meprotan with carbamazepine and colestyramine, as well as drugs that alkalize urine can significantly reduce the effect of phenindione.

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Storage conditions

Phenylin should be kept in a dry, dark place out of the reach of small children.

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Shelf life

Phenylin is allowed to be used for 3 years from the date of release of the drug.

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Reviews

Phenylin is considered one of the most effective drugs with this type of pharmacological action - it works well in improving the condition of the blood. This fact is noted on many medical forums.

Therapy with this drug helps most patients restore normal blood clotting. At the same time, literally after 7 days of the course, the patient experiences general improvements, cramps and numbness in the legs disappear. Although some patients experience increased nosebleeds, doctors believe that such changes during the therapy period are completely normal. Often, after the course is completed, this disorder completely disappears.

In addition to discussions of the effects and effectiveness of the drug, among patient reviews you can often find messages that Phenylin is often counterfeited, and therefore when buying it you need to be extremely careful not to buy a fake. That is why it is recommended to buy drugs only in pharmacies that have reliable recommendations.