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Health

Phenyhydidine

, medical expert
Last reviewed: 10.08.2022
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Phenigidine is a selective antagonist of the Ca element, which acts primarily on the vessels. It is a derivative of the dihydropyridine element.

trusted-source[1], [2], [3], [4], [5], [6], [7], [8], [9], [10]

Indications of the phenyhydidine

It is used when the pressure increases, which develops against the backdrop of such SSS pathologies as Raynaud's syndrome, arterial-type hypertension, and hypertrophic form of cardiomyopathy.

The drug is used to quickly eliminate the hypertensive crisis, and in addition to preventing the development of angina attacks (eg, IHD).

In addition, the drug is used in pulmonological practice - for the treatment of bronchial obstructive syndrome, as well as hypertension in the lungs.

trusted-source[11], [12], [13], [14], [15], [16], [17], [18]

Release form

The release is carried out in tablets, in an amount of 10 pieces inside the blister pack. The box contains 5 blisters with tablets.

Pharmacodynamics

The active element, which is an antagonist of Ca ions, blocks Ca channels inside arterial and cardiomyocyte cells. This allows nifedipine to affect the vessels of the peripheral type and heart, contributing to their expansion.

The medicine does not affect the smooth muscle tone of the veins. This helps reduce the values of blood pressure, reduce the resistance of peripheral vessels (mainly - arterioles) and the need for cardiomyocytes in oxygen. As a result, there is a significant decrease in the total load on the cardiac function.

Among the properties of nifedipine is also the suppression of platelet aggregation.

trusted-source[19], [20], [21], [22], [23]

Pharmacokinetics

The drug has a rapid absorption and demonstrates the rapid development of medication after admission. Peak values of nifedipine within the blood are noted after 0.5 hours after oral administration of the tablet.

The period of metabolization, as well as half-life lasts about 2-4 hours.

Excretion of metabolic products occurs through the kidneys, with urine. Some of the inactive decay products are found in feces.

trusted-source[24], [25], [26], [27], [28], [29], [30], [31], [32], [33]

Dosing and administration

The size of a portion is selected for each patient separately (taking into account the accompanying pathologies, age, and also how the body responds to treatment, etc.). The standard size of the minimum serving is 10 mg (sometimes it can reach 20 mg), and the frequency of receptions per day is a maximum of 4.

During the treatment of stenosis in the area of the coronary arteries, a minimum of 50-100 mg of the drug is required. A day is allowed to use no more than 12 tablets of the drug.

To eliminate attacks of hypertensive crisis or angina, it is required to put a pill of the drug under the tongue and wait until it completely dissolves. Also should be at least 1 hour lie down.

Correct the size of the portion should be very carefully, gradually increasing or decreasing the level of the active element. To avoid the appearance of side effects, you should use Fenigidin with food.

The duration of treatment is selected in accordance with the indications. Often it is about 1-2 months. Then the treating doctor should choose another treatment regimen.

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Use of the phenyhydidine during pregnancy

It is forbidden to prescribe Fenigidin for breastfeeding and pregnant women, because the corresponding drug testing has not been carried out. Therefore, one can expect from nifedipine a teratogenic and embryotoxic effect.

The drug passes into the mother's milk.

Contraindications

The main contraindications:

  • reduced systolic pressure;
  • severe degree of heart failure;
  • collapse;
  • hypersensitivity to the active ingredient or dihydropyridine derivatives;
  • stenosis of the aorta;
  • shock state of cardiogenic origin;
  • exacerbated myocardial infarction.

trusted-source[34], [35], [36], [37]

Side effects of the phenyhydidine

The use of a drug can trigger the appearance of such side effects:

  • disorders of the CCC function: a sharp decrease in blood pressure, swelling of the legs, the development of asystole, bradycardia or tachycardia, and in addition reddening of the skin in the face and chest;
  • problems in the work of the central nervous system: sleep disorders, a moderate feeling of drowsiness, problems with visual perception, the appearance of tremors in the limbs, and in addition migraine and dizziness;
  • disorders of the gastrointestinal tract: the appearance of heartburn, nausea, or diarrhea, and in addition suppression of hepatic function.

trusted-source[38], [39], [40], [41], [42]

Overdose

As a result of poisoning with phenygidine, the level of systolic blood pressure decreases (with a risk to health). Against this backdrop, there are such manifestations: collapse, bradycardia, a decrease in blood pressure, headache, and in addition a heart rhythm disorder, as well as conduction.

When there are signs of intoxication, immediately wash the affected stomach and give activated charcoal. For especially severe disorders, a 10% solution of calcium chloride should be administered iv.

trusted-source[45], [46], [47], [48], [49]

Interactions with other drugs

The drug has a more pronounced effect in the case of combined administration with other antihypertensive drugs, diuretics, nitrates, cimetidine, tricyclics, and in addition ranitidine.

The combination with β-adrenoblockers can lead to a disorder of circulatory processes in the region of the heart muscle and potentiation of hypotension of an arterial nature.

The effect of nifedipine is weakened when the drug is combined with rifampicin, calcium drugs, carbamazepine, phenytoin, and phenobarbital.

Combined use with quinidine, and in addition digoxin or theophylline leads to a change in the plasma values of these drugs.

Ethyl alcohol is able to potentiate the effects of nifedipine, which leads to a feeling of weakness and dizziness, and in addition to the disorder of the processes of coronary circulation.

trusted-source[50], [51], [52], [53]

Storage conditions

Fenigidine is required to be kept out of the reach of children, in a dark and dry place. Temperature values are within 8-15 ° C.

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Shelf life

Fenigidine is required to be taken for 3 years from the date of manufacture of the drug.

Reviews

Fenigidine is considered to be an obsolete drug, and due to the presence of a rather large number of restrictions on the use of the doctors increasingly appoint in its place more modern and safe medicinal analogues.

Most reviews contain information that the drug often provokes the appearance of negative reactions, which causes patients to worry about their own health. But it must be taken into account that all of them confirm that the medicine demonstrates high efficiency, especially in case of a sharp increase in systolic blood pressure or the development of anginal attacks.

The difference between phenygidine and other antihypertensive agents is the presence of additional properties, because the active element not only reduces pressure values, but also has an atherosclerotic effect. Patients have different opinions about this drug: some decide to use it, not paying attention to the presence of severe side symptoms, and others prefer to use safer modern medications that lower the blood pressure more smoothly, and do not lead to the appearance of negative symptoms.

Attention!

To simplify the perception of information, this instruction for use of the drug "Phenyhydidine" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

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