Penicillin g sodium salt

Penicillin g sodium salt helps to block peptidoglycan binding of the bacterial membrane sensitive to drugs, thereby leading to their lysis.

The drug is an antibiotic from the category of bio-artificial penicillins. Possesses bactericidal activity, slowing down the binding of microbes inside the cell membranes. [1]

Novocaine benzylpenicillin salt has a longer therapeutic effect in comparison with K and Na salts. [2]

Indications Penicillin g sodium salt

It is used in the case of such lesions and diseases:

• pleural empyema, meningitis , pneumonia;
• septicemia or sepsis ;
• endocarditis or pericarditis;
• infection in the area of the bile and urethra ducts;
• lesions of mucous membranes and epidermis with soft tissues;
• diseases of the ENT organs;
• osteomyelitis;
• bacteremia, anthrax, erysipelas;
• actinomycosis or diphtheria;
• ophthalmoblenorrhea;
• syphilis or gonorrhea.

Release form

The release of the medicinal substance is realized in the form of a lyophilisate for the preparation of injection liquid (volume 1 million units), inside bottles, 100 pieces per pack.

Pharmacodynamics

The drug demonstrates the effect on such bacteria:

• gram-positive: diphtheria corynebacterium, streptococci (this includes pneumococci), staphylococci, as well as anthrax bacillus;
• gram-negative: meningococci and gonococci;
• spore-forming anaerobes;
• actinomycetes and Spirochaetaceae.

Staphylococcal strains capable of producing penicillinase have drug resistance. [3]

The medication undergoes destruction inside the acidic environment.

Pharmacokinetics

After an intramuscular injection, the substance is absorbed at a high speed from the injection site. Extensive distribution within tissues with fluids. Benzylpenicillin crosses the placenta without complications, as well as (in the case of inflammation affecting the lining of the brain) the BBB.

The half-life is half an hour. Excretion is carried out in the urine.

Dosing and administration

The dosage of the medicine is selected individually. The solution should be administered subcutaneously, and in addition intravenously, intramuscularly, or endolumbar.

Portions of intravenous and intramuscular injections for adults per day range from 250 thousand / 60 million.Infants under 1 year old are used 50-100 thousand U / kg per day, and children from 1 year old - 50 000 U / kg. If required, the daily portion can be increased by 200-300 thousand U / kg; if there are strict indications - up to 500 thousand U / kg. Enter 4-6 times a day.

Endolumbar injections are performed taking into account the disease and its intensity. For adults, the serving size ranges from 5-10 thousand units, and for children - 2-5 thousand.

It is necessary to dissolve the medication in a sterile injection liquid or 0.9% NaCl in a proportion of 1000 U / ml. Before the injection (taking into account the ICP indicators), it is necessary to extract about 5-10 ml of CSF, and then add it to the medicinal solution in equal proportions.

Subcutaneously benzylpenicillin is used for injecting infiltrates (100-200 thousand U / ml 0.25-0.5% novocaine liquid).

The duration of therapy with benzylpenicillin, taking into account the form of the pathology and its intensity, can be at least 7-10 days and a maximum of 2+ months.

Use Penicillin g sodium salt during pregnancy

Use in pregnant women is allowed only in situations where the likely benefits for the woman are more expected than the risks of negative consequences for the fetus.

If the introduction of drugs is required during lactation, the option of canceling breastfeeding should be considered.

Contraindications

It is contraindicated to use in case of intolerance to benzylpenicillin and other substances from the category of cephalosporins with penicillins.

Endolumbar injections are not given to people with epilepsy.

Side effects Penicillin g sodium salt

The main side symptoms:

• disorders associated with digestive function: nausea, diarrhea and vomiting;
• signs caused by chemotherapeutic effect: vaginal or oral candidiasis;
• disturbances in the work of the central nervous system: the use of large portions of benzylpenicillin (especially endolumbar) can provoke the appearance of neurotoxic symptoms: vomiting, convulsions, manifestations of meningism, nausea, coma and potentiation of reflex excitability;
• manifestations of allergies: epidermal rashes or rashes on the mucous membranes, fever, pain affecting the joints, Quincke's edema, eosinophilia and urticaria. There is information about the development of fatal anaphylactic signs.

Interactions with other drugs

Probenecid weakens the release of benzylpenicillin through the tubules, which increases the plasma index and the half-life of the latter.

Combination with antibiotics with bacteriostatic activity (tetracyclines) reduces the bactericidal effect of benzylpenicillin.

Storage conditions

Penicillin g sodium salt should be stored at temperatures not exceeding 25 ° C.

Shelf life

Penicillin g sodium salt can be used for a 5-year period from the date of manufacture of the therapeutic substance.

Analogs

An analogue of the drug is Benzylpenicillin.