Paracetamol by temperature: dosage, how to take

Paracetamol for fever is one of the most common treatments. It is prescribed for children, adults. This is the first aid that is prescribed for any fever, even in the case of an unexplained genesis. This tool allows you to not just lower the temperature. Additionally, it has an analgesic, mild anti-inflammatory effect. Let's take a closer look at the specifics of the action and especially the use of paracetamol.

What helps paracetamol?

Few people know what paracetamol actually helps. 

Paracetamol (or acetaminophen) is one of the most popular and most commonly used analgesics and antipyretic drugs in the world, produced without a prescription, both in single and multicomponent preparations. It is the drug of choice for patients who cannot be treated with non-steroidal anti-inflammatory drugs (NSAIDs), such as people with bronchial asthma, peptic ulcer disease, hemophilia, salicylate-sensitized people, children under 12 years old, pregnant or lactating women. [1]

Traditionally, it is considered to be an antipyretic. Nevertheless, many forget that in addition to lowering body temperature, paracetamol is able to normalize hemostasis, have an analgesic effect on the body, and to mildly arrest the inflammatory process. The temperature may decrease due to the direct antipyretic effect of the drug, as well as as a result of normalization of the state of the body, a decrease in the inflammatory process, and a decrease in the degree of irritation of nerve receptors. The effect of the drug is quite long. The temperature decreases almost always, since the drug has a normalizing effect on the thermoregulation center in the hypothalamus.

Is paracetamol feasible?

Often patients ask: "Is it possible to take paracetamol from the temperature?". Of course, paracetamol can and should be taken at temperature. [2] This is one of the main means of normalizing body temperature due to the effect on the thermoregulation center located in the hypothalamus. This center, in turn, has a normalizing effect on the whole organism as a whole, regulates temperature, and establishes homeostasis (stability and constancy of the internal environment of the body). Unlike many drugs, paracetamol almost always reduces temperature. This is possible due to the fact that the drug has an effect directly on the thermoregulation center, which, in turn, acts directly to normalize the body temperature due to changes in the physicochemical properties of the body. The main task of the thermoregulation center is precisely to control body temperature and maintain it within normal limits. It is this center that does not allow the temperature to rise too high, to fall too low.

Moreover, in the case of the development of an infectious or inflammatory process, the activity of the thermoregulation center may be blocked. Paracetamol contributes to its activation, due to which a cascade of reactions is launched aimed at normalizing body temperature and maintaining homeostasis. The advantage of the action of paracetamol is that when the thermoregulatory center is activated, the temperature always decreases, and quite quickly, regardless of the reason for its increase. In fact, this makes paracetamol a universal antipyretic, in contrast to the means of symptomatic or etiological therapy, in which the temperature normalizes when the cause of its increase is eliminated, as a result of the pathological process.

Indications Paracetamol by temperature

Paracetamol is prescribed to normalize body temperature (with elevated body temperature, hyperthermia), with a febrile state. The drug can be prescribed to normalize temperature indicators, regardless of the reason for its increase. 

Paracetamol is the most widely used analgesic in the world and is recommended by WHO as the first line of treatment for all pain conditions. [3] It is prescribed to reduce pain, eliminate pain from any genesis and any localization. As a rule, the drug is effective for pain of mild to moderate intensity and severity. [4] In severe pain, the drug will be ineffective. 

As an indication for use of paracetamol acts migraine, headache,  [5],  [6],  [7] toothache,  [8] neuralgia,  [9] myositis,  [10] radiculitis. [11] It helps with pain that occurs during menstruation or in the premenstrual period. [12] The drug can be given to reduce pain during attacks of hepatic, renal colic, gastritis, cystitis, and other acute inflammatory processes. It can also be used as a first aid in traumatic conditions, infectious and inflammatory processes, and burns. Due to the fact that the drug has a slight anti-inflammatory effect, it can be used as an adjunct in any inflammatory and infectious processes, regardless of the zone of their localization. It is effective for tonsillitis and sinusitis, cystitis, hepatitis, gastritis, pyelonephritis, etc. With any malaise, weakness, chills, somatic discomfort, traumatic condition, this tool can be used as the main or auxiliary tool. It is also included in the complex therapy to enhance the effect of certain drugs, providing a comprehensive analgesic, anti-inflammatory, antipyretic effect. [13]

Paracetamol for colds without fever

Paracetamol is often prescribed for colds without fever. It surprises many. But there is nothing surprising in this. It is traditionally believed that paracetamol is an antipyretic. But this is only one of its effects. Most people forget that in addition to the antipyretic effect, paracetamol also has anti-inflammatory and analgesic (analgesic) effects. In addition, it normalizes homeostasis, that is, it is capable of maintaining the constancy of the internal environment of the body, primarily its body fluids, which is very important for accelerating recovery. Due to the synergistic effect, the drug often enhances the effects of other drugs, in particular antibiotics, anti-inflammatory drugs. This significantly increases the effectiveness of treatment, accelerates recovery. If you take into account that with a cold, even if it runs without a temperature, there is always a violation of homeostasis, an inflammatory process develops, minimal pain appears, paracetamol will be extremely effective. [14]

Release form

The drug paracetamol is available in the form of tablets, a concentration of 500 mg. In this case, the tablets are packaged in packs of 10 pieces. They can be sold in packages without a cardboard bundle, or additionally packed in cardboard bundles of 1-10 pieces. There are also cardboard packages containing 20, 30, 40, 50, 60, 80 and 00 cell packages. You can also find tablets produced in banks of 10, 20, 30, 40, 50 and 100 pieces. Banks are in addition packed in cardboard packs. Paracetamol can also be produced in the form of a syrup for children and suppositories.

Tablets

Paracetamol in tablets is prescribed for fever, for various pains, for inflammatory processes of any localization and severity. The concentration of the active substance is 500 mg. This is the standard single dose that must be taken by an adult. Children, depending on age, individual characteristics, are prescribed a significantly lower dose. Typically, the daily dose of the drug is 2 grams. Paracetamol tablets can be taken separately with fever, or with pain, inflammation. They can also be included in complex therapy.

Candles

Paracetamol suppositories are prescribed primarily at temperature. They should be used at high temperatures, as well as children. Suppositories act much faster than pills. This is due to the fact that they are much faster absorbed into the body, penetrating through the mucous membranes, and penetrate the blood. While the tablets must first dissolve in the stomach, then absorb into the blood through the walls of the gastrointestinal tract. In this case, their partial neutralization occurs under the action of juices and hydrochloric acid of the gastrointestinal tract, as well as under the action of salivary gland enzymes. Accordingly, a much lower concentration of the active substance penetrates into the blood. With the introduction of suppositories, direct penetration of the active substance into the blood occurs, without additional neutralization and loss of activity. The introduction of paracetamol suppositories is carried out rectally. In some cases, for example, with gynecological diseases, inflammations in the female reproductive system, paracetamol in the form of suppositories is prescribed intravaginally.

Syrup

Paracetamol is available as a syrup. Syrup is given to children. For adults, it is ineffective, because the dosage for an adult will be insufficient to have a therapeutic effect. As a rule, syrup is available in bottles. A measuring spoon or measuring cup is attached to it. Dosage for children depends on age, disease, on what purpose the drug is prescribed. It is necessary to consult a doctor, choose the optimal dosage and method of administration for the child. A single dose of the drug, or prolonged treatment may be required.

Pharmacodynamics

The drug is an analgesic-antipyretic. When studying pharmacodynamics, it is noteworthy that the drug has a complex effect on the body. First of all, it normalizes body temperature. This is due to the effect on the center of thermoregulation, activating it. The thermoregulation center, in turn, affects the main indicators of the biochemical environment, normalizes and stabilizes homeostasis in the body. It also has a mild analgesic and anti-inflammatory effect. In this case, the drug has a moderate effect: it is able to relieve mild pain, relieve moderate pain. However, the drug will be ineffective in severe pain syndromes. This is due to the fact that the relief of pain and inflammation occurs due to inhibition of prostaglandin synthesis. The drug has an effect mainly on the hypothalamic zone. [15], [16]

Pharmacokinetics

In the analysis of pharmacokinetics, such a property as the ability to quickly absorb through the walls of the gastrointestinal tract attracts attention. The main absorption occurs in the small intestine. However, the loss of activity of the drug is negligible. Even more absorption occurs when the drug is administered rectally in the form of suppositories. At the same time, activity remains high. In the future, when a substance penetrates into the blood, its transport through the body is carried out. The substance is transported by diffusion (passive transport). [17]

Achieving an active concentration of the active substance in the body is achieved after 10-60 minutes. The approximate diffusion rate is 6 μg / ml. Gradually, the concentration and speed of transport decreases. There is an intensive distribution of the drug in the tissues. The bulk of the substance penetrates into liquid tissues. This significantly increases the activity of the drug. Paracetamol practically does not penetrate into adipose tissue and cerebrospinal fluid. The substance is approximately 10% bound to blood proteins. With an overdose, the percentage of binding can increase dramatically. The drug is metabolized by injection. In this case, the drug conjugates with glucuronide and sulfate. With an overdose, an accumulation of metabolites in the body, mainly in the liver, can occur, due to which poisoning occurs, severe intoxication develops. The half-life of the drug is approximately 3-4 hours. In patients with liver pathology, this period increases dramatically. Renal clearance is 5%. It is excreted mainly in urine. In a pure unbound form, approximately 5% of the active substance is excreted. [18]

How long does paracetamol work?

Answering the question of how much paracetamol acts, it is impossible to answer unambiguously and categorically. There are many parameters on which the time of the onset of the expected effect depends. Usually the active concentration of the active substance in the blood is reached after 10-60 minutes. This is due to the rate of absorption of the active substance in the blood, which, in turn, is largely determined by the method of administration of the drug. So, the highest activity is observed when the drug is administered in the form of rectal suppositories. Suction of the drug is carried out after 3-5 minutes. After this time, you can feel the first effect. As practice shows, the drug most quickly begins to act in children. In adults, the drug acts a little later. It is also worth noting that with liver pathologies, the drug is absorbed much longer, and activity manifests itself much later. For example, in people with hepatitis or cirrhosis, the effect can be achieved in about 30-90 minutes.

Dosing and administration

As a rule, the method of use of paracetamol and its optimal dose is determined by the doctor. Moreover, in many respects the method of application and the dose depend on the patient’s age, body weight, human history, the course of the disease, the presence or absence of hyperthermia. Children are given the drug in the form of a syrup, using a measuring spoon or glass. Usually give from 5 to 30 ml at a time, depending on age. For adults, a single dosage is 500 mg of the drug, the maximum daily dosage is no more than 2 grams per day. [24]

The toxic dose for a single acute administration of paracetamol in adults is traditionally defined as 150 mg / kg or 10 g  [25]. [26]

The recommended daily dose of paracetamol for children is usually taken equal to 75 mg / kg / day (15 mg / kg / dose, should not exceed five doses within 24 hours). Many doctors believe that a dose of 90 mg / kg / day is the "supra-therapeutic dosage." [27], [28]

Paracetamol by temperature in adults

Paracetamol is the main aid that is prescribed for any fever. It allows not only lowering the temperature, but also has an analgesic, mild anti-inflammatory effect. The temperature may decrease due to the direct antipyretic effect of the drug, as well as as a result of normalization of the state of the body, reduction of the inflammatory process. The drug is almost always active, since the drug has a normalizing effect on the thermoregulation center in the hypothalamus. This center, in turn, has a normalizing effect on the whole organism as a whole, regulates temperature.

Paracetamol from temperature is prescribed to adults in order to normalize body temperature (at elevated body temperature, hyperthermia), with a febrile state. The reason for the development of temperature is not important. Also, the drug is prescribed to reduce pain, eliminate acute inflammatory processes. It can also be used as a first aid in traumatic conditions.

The concentration of the active substance is 500 mg. This is the standard single dose that must be taken by an adult. The maximum daily dose of the drug is 2 grams. Paracetamol tablets can be taken separately with fever, or with pain, inflammation. Paracetamol suppositories are prescribed at high temperature. Suppositories act much faster than pills. This is due to the fact that they are much faster absorbed into the body, penetrating through the mucous membranes, and penetrate the blood.

The drug is an analgesic-antipyretic. When studying pharmacodynamics, it is noteworthy that the drug has a complex effect on the body. First of all, it normalizes body temperature.

Achieving an active concentration of the active substance in the body is achieved after 10-60 minutes.

Paracetamol for children

Doctors are often asked whether paracetamol can be given to a child from a fever. Paracetamol is really prescribed for children in temperature.

Firstly, this is one of the main means of normalizing body temperature. Secondly, the drug allows you to stop pain and inflammation.

Paracetamol is often prescribed for children with a cold without a fever, because in addition to the antipyretic effect, paracetamol also has anti-inflammatory and analgesic (analgesic) effects. [29]

For children, paracetamol is available mainly in vials in the form of syrup. A measuring spoon or measuring cup is attached to it. Dosage for children depends on age, body weight.

Also, children are recommended to use paracetamol in the form of suppositories for rectal administration. In this form, the drug acts much faster and more efficiently.

Achieving an active concentration of the active substance in the body is achieved after 10-60 minutes. It is excreted mainly in urine. In a pure unbound form, approximately 5% of the active substance is excreted.

Children under 2 years of age are not recommended to take the drug. Patients aged 2 to 10 years can use the drug in the form of syrup and suppositories. Children over 10-12 years old should take the drug in the form of tablets.

Paracetamol and analgin from temperature

From temperature, paracetamol and analgin are prescribed. These are two drugs that, when combined, enter into synergism, and can have an enhanced effect. Both drugs have antipyretic, anti-inflammatory and analgesic effects. With the combined use of two drugs, the duration of the drug increases, the antipyretic and analgesic effects increase. Usually take 250 mg of paracetamol and 250 mg of dipyrone (for adults). The advisability of taking such a combination of drugs for children should consult a doctor.

Co-administration of drugs at high temperature

At high temperatures, the combined use of drugs is practiced. Together, most drugs are more effective, because with the right dosage, there will be a mutual increase in exposure. Various combinations are recommended. Consider what they drink paracetamol from temperature.

So, paracetamol can be taken together with analgin, or aspirin (acetylsalicylic acid). An adult is prescribed from 250 or 500 mg of each of the drugs. Dosage is determined by temperature indicators. So, at temperatures up to 38.5 degrees, it is worth starting with 250 mg of each of the funds. If there is no improvement within 30 minutes, or the temperature continues to rise, you need to take another 500 mg of drugs (500 mg of paracetamol and 500 mg of dipyrone or aspirin). At temperatures above 38.5-39 degrees, you need to immediately take 500 mg of each of their funds.

Paracetamol is also taken with amidopyrine (250 or 500 mg each), mitasozone (200 mg) + paracetamol (250 or 500 mg), calcium pantothenate (100 mg) + paracetamol (250 or 500 mg).

Analgin plus with paracetamol

If paracetamol is ineffective, take analgin plus with paracetamol. This combination of products is effective, first of all, at high temperature. So, these funds are prescribed at temperatures above 38 degrees, or with the ineffectiveness of other antipyretic drugs. Often, this combination is used as an effective anti-inflammatory agent, to reduce and eliminate mild pain. These drugs are prescribed mainly for adults. The question as to whether this combination can be used to treat children needs to be decided with a pediatrician, given the accompanying history, the condition of the child, and his diagnosis.

Paracetamol with no-spy

Paracetamol with no-shpa, or paracetamol with drotaverine is prescribed, first of all, with severe pain, or with the inflammatory process. No-spa relieves spasm, relaxes tense muscles, eliminates cramps and muscle spasm. As a rule, this significantly eliminates pain. This combination of drugs can be used for attacks, pain of various origins, with convulsive syndromes. It is recommended for the relief of attacks of cystitis, hepatitis, hepatic and renal colic, cholecystitis, pancreatitis. It will help to stabilize the condition in the pre-medical period, during first aid for various attacks, injuries, burns. Also, this tool can be used to stop the inflammatory process and reduce high temperature.

Analgin with paracetamol and no-spear

Analgin is prescribed with paracetamol and no-shpa with a pronounced inflammatory process, paroxysmal pain, at high temperature. In this case, the dosage is determined by the severity of the condition. In the most severe cases, for example, with attacks of cystitis, gastritis, colic, you can use these drugs (on a tablet of each of them). With moderate inflammation and pain, you can use 0.5 tablets of paracetamol, 0.5 tablets of analgin and 1 tablet of no-shpa. These funds can be used for injuries and burns as a first aid, until the arrival of an ambulance. The doctor who will provide further assistance should be informed about what funds were given to the person. This will avoid complications and side effects. For example, analgin has an additional vasodilator and blood-thinning effect, and therefore the risk of bleeding and hypertension increases sharply.

Analgin with paracetamol and aspirin

At high temperatures, which do not go astray for a long period of time, you can try analgin with paracetamol and aspirin. The initial dosage is 250 mg of each drug. If this combination is ineffective, you can try to drink a higher dosage - 500 mg of each drug. The next dose of the drug can be drunk no earlier than 30-40 minutes after taking the previous one. You can’t take these drugs for a long time, because they can cause a number of side effects, including a violation of blood coagulation, an increase in the inflammatory process. Children under 6 years of age are not recommended to take this combination.

Suprastin with No Shpa and Paracetamol

With a pronounced inflammatory process, acute pain syndrome, suprastin with no-shpa and paracetamol can be taken. These drugs effectively relieve the inflammatory process, reduce the level of histamine in the blood, normalize the state of the autonomic nervous system, muscles. No-spa will help relieve spasm, relax muscles, eliminate muscle tone. Suprastin fights the inflammatory process, normalizes metabolic processes in the body. With the help of paracetamol, you can reduce body temperature, eliminate the inflammatory process. It is recommended to take the drugs in the following dosage: suprastin (1 tablet) + no-spa (1 tablet) + paracetamol (0.5 or 1 tablet).

Aspirin with Paracetamol

Aspirin (acetylsalicylic acid) and acetaminophen (paracetamol) are often used to treat fever and other symptoms of an upper respiratory tract infection. Both are available over the counter for use in standard recommended doses of 500 and 1000 mg per single use. A 2005 multicenter, randomized, double-blind, placebo-controlled study showed the same efficacy of a single dose of 500 and 1000 mg aspirin and 500 and 1000 mg paracetamol in treating fever and other symptoms of upper respiratory tract infection in adults, compared with placebo. [30]

Aspirin with paracetamol is recommended to be taken at elevated body temperature (over 38.5-39 degrees), with intoxication syndrome. If paracetamol does not help you, try taking 1 tablet of aspirin and 1 tablet of paracetamol. This combination helps to eliminate pain, reduce the inflammatory process. Drugs are contraindicated in violation of blood coagulation processes. It is also not recommended for children under 10 years of age.

Ibuprofen with paracetamol

For pain that occurs against the background of an inflammatory or infectious process, it is recommended to take ibuprofen with paracetamol. This combination of products can be recommended for people over 10 years old. It is better to take these drugs for colds, inflammatory and infectious processes that are not accompanied by fever. Ibuprofen has a predominantly anti-inflammatory effect, relaxes muscles, eliminates spasm. This relieves pain, prevents the progression of inflammation. It is recommended to take 0.5 tablets of ibuprofen + 1 tablet of paracetamol. If the indicated combination is ineffective, take a whole tablet of ibuprofen and a whole tablet of paracetamol.

Citramon and Paracetamol Together

In some cases, doctors recommend that patients take citramone and paracetamol together. They mutually reinforce the action of each other, removing the inflammatory process, and eliminating the pain syndrome. A side effect of these drugs is a decrease in temperature. The main effect is achieved due to the fact that citramone has a strong analgesic effect, and to some extent, relieves pain. Paracetamol also has a predominantly antipyretic and anti-inflammatory effect, due to which there is a decrease in pain, muscle relaxation.

This combination of drugs is quickly absorbed through the walls of the digestive tract, enters the bloodstream, and then penetrates directly into the target tissue. It is also worth noting that at such a dosage, the drugs are in the blood for a rather long time, due to which it is possible to achieve a prolonged effect of the drugs.

Lytic mixture of temperature with paracetamol

In some cases, a temperature lytic mixture with paracetamol is prescribed. It has antipyretic, analgesic and anti-inflammatory properties. This mixture is easily soluble in water, practically has no side effects, contraindications are minimal. Basically, the mixture can not be taken with individual intolerance to the drug, with an allergic reaction.

Triad from temperature

Triad is assigned by temperature. It is an effective herbal remedy. It is produced as a plant material (grass). Also in the pharmacy you can find a triad in the form of a drug, available in the form of tablets, compressed drugs. In general, triad is known as an antiparasitic agent, however, it has a pronounced anti-inflammatory and analgesic. It is used in the form of decoctions, infusions.

Vegetable decoction of triad from temperature is used as follows: about 1-2 tablespoons of triad is poured with a glass of boiling water. Then the tool is given the opportunity to infuse for 30-40 minutes. A glass of broth must be drunk within a day.

To prepare the infusion, you need to pour 3-4 tablespoons of plant material into a glass of alcohol or vodka. The tool is infused for 2-3 days, after which it can be taken 2-3 tablespoons 1-3 times a day. Tablets are taken in accordance with the instructions.

Use Paracetamol by temperature during pregnancy

The ability of paracetamol to penetrate the placental barrier is known. Nevertheless, there is no negative effect of paracetamol on the fetus, and there is no teratogenic effect. Clinical studies have been repeatedly carried out, as a result of which it was found that the drug has no toxic or mutagenic effects on the body.

A 2010 US National Birth Defect Prevention study found that using paracetamol during the first trimester does not increase the risk of serious birth defects. [19]

All this allows the use of the drug during pregnancy. The drug significantly reduces pain, temperature, and the inflammatory process. During pregnancy, you can not tolerate pain. Temperature and the inflammatory process can negatively affect the health status of both the fetus and the mother. That is why, if there is evidence, the drug can be taken during pregnancy. But nevertheless, it is better to consult a doctor to avoid cases of individual intolerance, side effects.

Paracetamol for breastfeeding against temperature

From the temperature during breastfeeding, you can take paracetamol. However, it must be borne in mind that the drug passes into breast milk. Therefore, you need to weigh all the benefits of taking the drug and the possible risks of taking it, and then make the appropriate decision. If the benefit of taking the drug significantly exceeds the harm to the child, it must be taken. It should also be borne in mind that when the temperature rises above 38 degrees, the child can not be fed. Therefore, it is better to take paracetamol. In addition, almost always an increase in temperature is accompanied by a pronounced or latent inflammatory process. Therefore, it is necessary to eliminate the inflammatory process. [20], [21]

Contraindications

Paracetamol is a pure active ingredient that has a direct antipyretic and anti-inflammatory effect. At the same time, it has practically no contraindications. It can not be taken only in cases of individual intolerance to paracetamol, with increased sensitivity to it. Also as a contraindication to the use of paracetamol is chronic alcoholism. Otherwise, the drug is relatively safe and harmless. It can be taken even by pregnant women and children. [22]

Side effects Paracetamol by temperature

Paracetamol may have side effects. So, often against the background of its intake, patients note dyspeptic disorders. 

Paracetamol is one of the most dangerous compounds in medicine, causing hundreds of deaths in all industrialized countries due to acute liver failure. [23]With prolonged use of the drug, liver disorders are observed. This is due to the fact that the drug can accumulate in the liver, and therefore have a hepatotoxic and intoxication effect. 

In some cases, the drug affects the circulatory system: thrombocytopenia, leukopenia, neutropenia, agranulocytosis are observed. Allergic reactions are possible, which are manifested mainly in the form of a skin rash, backache, urticaria. With a tendency to allergic reactions of an immediate type, anaphylactic shock, suffocation, Quincke's edema can be observed.

Overdose

Cases of an overdose of paracetamol are unknown, since the excess of the drug is excreted out unchanged through the kidneys. Also, cases of overdose are observed if a person has impaired renal and hepatic function. In this case, there is an intensive accumulation of the drug in the liver, due to which liver damage occurs, and signs of intoxication develop, such as nausea, vomiting, headache, dizziness.

Overdose treatment includes suppressing the absorption of paracetamol from the gastrointestinal tract (deactivation, gastric lavage, activated charcoal), removing paracetamol from the blood and using antidotes to prevent the formation or detoxification of metabolites. [31]

When the first signs of poisoning appear, you need to cancel the further administration of the drug, induce vomiting, then drink the sorbent (white coal, activated carbon). After this, it is necessary to provide the patient with a plentiful drink, peace. Call an ambulance, or consult a doctor.

Interactions with other drugs

It must be borne in mind that paracetamol interacts with other drugs. So, it is not recommended to be taken together with inducers of microsomal liver enzymes. In this case, a hepatotoxic effect occurs, there is a risk of toxic damage to the liver and kidneys. With simultaneous administration with anticoagulants, blood coagulability is significantly reduced, there is a risk of blood circulation. Absorption decreases sharply while taking with anticholinergics. With simultaneous administration with diuretics, oral contraceptives, the effectiveness of paracetamol is sharply reduced. It cannot be taken together with sorbents (activated carbon, and other means). In this case, the effectiveness and bioavailability of paracetamol decreases sharply. When combined with diazepam, the excretion of drugs is sharply reduced. [32]

Storage conditions

The drug must be stored at a standard temperature not exceeding 25 degrees. As a rule, storage conditions are written on the packaging. They must be observed. It is important that the tablets be stored in a dry, dry and dry place. The place should not be accessible to children or animals.

Shelf life

Typically, paracetamol has a shelf life of approximately -3 years. As a rule, the production date is indicated on the package. For syrup, the shelf life is usually much lower. It is approximately 1.5 to 3 years. Suppositories are stored for approximately 1 year. It should be borne in mind that an opened bottle with syrup can be stored for about 3-4 weeks.

What to do if the temperature does not drop from paracetamol?

Often you hear the question of what to do if the temperature does not drop from paracetamol. Such cases are observed, especially if you take paracetamol for a long period of time without changing the tool. In some cases, individual resistance, intolerance to the drug is observed. Always in case of drug failure, you need to look for an alternative. Let's consider the possible options.

Paracetamol and analgin. With the combined use of two drugs, the duration of the drug increases, the antipyretic and analgesic effects increase. Usually take 250

Paracetamol with aspirin (acetylsalicylic acid). An adult is prescribed from 250 or 500 mg of each of the drugs. Dosage is determined by temperature indicators. At temperatures above 38.5-39 degrees, you need to immediately take 500 mg of each of their funds.

Paracetamol with amidopyrin (250 or 500 mg).

Mitasosone (200 mg) + paracetamol (250 or 500 mg).

Calcium pantothenate (100 mg) + paracetamol (250 or 500 mg).

Analgin plus with paracetamol. If paracetamol is ineffective, take analgin plus with paracetamol. This combination of products is effective, first of all, at high temperature. So, these funds are prescribed at temperatures above 38 degrees, or with the ineffectiveness of other antipyretic drugs.

Paracetamol with no-shpa, or paracetamol with drotaverine is prescribed for severe pain, or for the inflammatory process. Dosage: 1 tablet of paracetamol + 1 tablet of no-shpa.

Analgin is prescribed with paracetamol and no-spear is prescribed for severe inflammatory process, paroxysmal pain, at high temperature. With moderate inflammation and pain, you can use 0.5 tablets of paracetamol, 0.5 tablets of analgin and 1 tablet of no-shpa. These funds can be used for injuries and burns as a first aid, until the arrival of an ambulance.

Analgin with paracetamol and aspirin. At high temperatures, which do not go astray for a long period of time, you can try analgin with paracetamol and aspirin. The initial dosage is 250 mg of each drug. If this combination is ineffective, you can try to drink a higher dosage - 500 mg of each drug.

With a pronounced inflammatory process, acute pain syndrome, suprastin with no-shpa and paracetamol can be taken. It is recommended to take the drugs in the following dosage: suprastin (1 tablet) + no-spa (1 tablet) + paracetamol (0.5 or 1 tablet).

Aspirin with paracetamol is recommended to be taken at elevated body temperature (over 38.5-39 degrees), with intoxication syndrome. If paracetamol does not help you, try taking 1 tablet of aspirin and 1 tablet of paracetamol.

For pain that occurs against the background of an inflammatory or infectious process, it is recommended to take ibuprofen with paracetamol. It is recommended to take 0.5 tablets of ibuprofen + 1 tablet of paracetamol. If the indicated combination is ineffective, take a whole tablet of ibuprofen and a whole tablet of paracetamol.

Citramon and paracetamol. They mutually reinforce the action of each other, removing the inflammatory process, and eliminating the pain syndrome. A side effect of these drugs is a decrease in temperature. Take 1 tablet of each of the funds.

Which is better from temperature?

When deciding which is better from the temperature, one must proceed from what the cause of the temperature is, what accompanying symptoms are observed, what are the characteristics of the physiological state of the patient.

Paracetamol is the main remedy for temperature. Additionally, it has an analgesic, mild anti-inflammatory effect. The temperature may decrease due to the direct antipyretic effect of the drug, as well as as a result of normalization of the state of the body, reduction of the inflammatory process. From paracetamol, the temperature decreases almost always, since the drug has a normalizing effect on the thermoregulation center in the hypothalamus.

Due to the fact that the drug has a slight anti-inflammatory effect, it can be used as an adjunct in any inflammatory and infectious processes, regardless of the zone of their localization. It is also included in the complex therapy to enhance the effect of certain drugs, providing a comprehensive analgesic, anti-inflammatory, antipyretic effect.

Acts pretty fast. Usually the active concentration of the active substance in the blood is reached after 10-60 minutes.

You also need to consider that the use of the drug during pregnancy is allowed. The drug significantly reduces pain, temperature, and the inflammatory process. If indicated, the drug can be taken during pregnancy. It is indispensable during lactation (breastfeeding).

It must be borne in mind that when the temperature rises above 38 degrees, the child can not be fed. Therefore, it is better to take paracetamol. Paracetamol is prescribed for children in temperature. Firstly, this is one of the main means of normalizing body temperature. Secondly, the drug allows you to stop pain and inflammation. Paracetamol is often prescribed for children with a cold without a fever, because in addition to the antipyretic effect, paracetamol also has anti-inflammatory and analgesic (analgesic) effects.

• Paracetamol or Nurofen

If you decide what to take: paracetamol or nurofen, it is better to choose paracetamol. It is an effective antipyretic, anti-inflammatory and analgesic that can be used by both children and adults. The drug can be taken even during pregnancy and breastfeeding. It practically does not have side effects, has no contraindications (except in cases of chronic alcoholism and individual intolerance to the drug). [33]

As for Nurofen, it has a negative effect on the liver, and can cause an overdose. Intensive excretion of the substance through the kidneys creates an increased burden on the kidneys and urinary system. Accordingly, the drug should not be taken during pregnancy, feeding, kidney and liver diseases. In addition, it can cause allergies and numerous side effects.

• Aspirin (acetylsalicylic acid) or paracetamol

If the choice is between aspirin (acetylsalicylic acid) and paracetamol, it is better to opt for paracetamol. This is due to the higher biological activity of the drug, and, accordingly, its higher efficiency. Secondly, paracetamol has fewer side effects and contraindications. It can be taken by everyone, except in cases of individual intolerance to the substance. [34]

• Ibuclin

Ibuklin can be considered as an analogue of paracetamol. However, it has a more pronounced anti-inflammatory and analgesic effect. Paracetamol, on the contrary, has a more pronounced antipyretic effect. It is necessary to take into account the fact that paracetamol has practically no contraindications or side effects. This is a relatively safe tool that can be used by both children and pregnant and lactating women. As for ibuklin, it has numerous side effects and contraindications. It can not be taken during pregnancy and lactation, it is contraindicated in children under 10-12 years of age.

Reviews

If you analyze the reviews of paracetamol, then you can find both positive and negative reviews. Paracetamol does not help everyone with temperature. It helps one immediately and in relatively small concentrations, while for others, even high dosages of this drug turn out to be ineffective. As a rule, this depends on the individual sensitivity of the body. If paracetamol does not help, you can try it in combination with other agents.