Pantose

Pantose is a medicine used for therapy with ulcers and GERD. Included in the group of drugs that inhibit the proton pump.

[1], [2]

Indications of the pantose

Infusion solution is used in situations where the patient is unable to use the drug inside. It is used:

• with gastric or intestinal ulcers of a peptic character;
• with bleeding in the gastrointestinal tract or inclination to them;
• with GERD;
• to reduce the volume of secreted gastric juice with gastrinoma.

[3], [4]

Release form

The release occurs in the form of a lyophilizate, from which an injectable medical solution is made.

[5], [6], [7], [8], [9]

Pharmacodynamics

The element of pantoprazole is an antisecretory substance that promotes the blocking of secretion processes, slowing down H ⁺ / K ⁺ -ATPase (proton pump). The drug depresses the terminal stage of the formation of hydrochloric acid, while the origin of the substance-stimulus does not matter. Panthosis has a rather long antisecretory effect (duration - about 24 hours).

[10], [11], [12], [13], [14], [15]

Pharmacokinetics

After intravenous injection, the half-life of the active element is approximately 1 hour. The drug is exposed to hepatic metabolism with the help of the hemoprotein P450 system.

Excretion mainly occurs in the urine. The drug can not be excreted by the hemodialysis procedure.

[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]

Dosing and administration

Before administration, the lyophilizate is dissolved using a 0.9% solution of sodium chloride (10 ml is required). It is necessary to wait for the transformation of the lyophilizate into a homogeneous liquid (it can be stored under a temperature of 25 ° C for a maximum of 2 hours), and then dilute it with a 5% glucose solution, ringeralactate solution or a solution of sodium chloride (0.9%) in 100 ml .

Adults often need to administer 40 mg of the solution once a day. To conduct the procedure is necessary daily for 7-10 days.

With gastrinoma therapy begins with the administration of 80 mg of the drug at intervals of 12 hours. Further, the dosage is allowed to gradually increase to 120 mg with an interval of 12 hours; or you can continue to administer the initial 80 mg at intervals of 8 hours. The maximum daily allowance is 240 mg. Each infusion should last at least 15 minutes.

During the treatment of bleeding ulcers, a bolus method is required to administer 80 mg of drugs. Injection is performed after 2-5 minutes after the procedure of hemostasis. Then immediately begins a drip IV infusion of the solution at a rate of 8 mg / h. This procedure lasts 72 hours. At the end of these activities, the patient is transferred to pantoprazole in tablets.

Often, the drug is administered iv in the drip method in a ratio of 3 mg / minute, but with a duration of more than 15 minutes.

When infusions are introduced, an infusion system is used, equipped with a special filter that prevents the penetration of precipitates (they can form inside the ready-made therapeutic solution) inside the circulatory system. It should be noted that the infusion system must be filled with the solvent used for the initial dilution of the lyophilizate before it is connected.

[34], [35], [36], [37]

Use of the pantose during pregnancy

Information on the safety of Pantose in pregnant or lactating mothers is not available. Because of this, it is possible to apply it during these periods exclusively for life indications, taking into account the ratio of benefits for the woman and the risk of negative consequences for the fetus.

For the period of therapy it is required to refuse breastfeeding.

Contraindications

It is forbidden to prescribe parenteral administration of the drug to people with hypersensitivity to pantoprazole. Also, the solution is contraindicated for administration to children.

[26], [27], [28]

Side effects of the pantose

In general, the drug is well tolerated. But using the solution in large doses (IV injection) can cause pain in the sternum, abdominal pain and itching with a rash on the skin. More rarely are headaches, dyspeptic manifestations, vomiting, various disorders at the site of injection, severe nausea, runny nose, diarrhea, and in addition dizziness.

[29], [30], [31], [32], [33]

Interactions with other drugs

It is forbidden to mix the drug with other agents for parenteral use.

In addition, Pantose is incompatible with therapeutic solutions that are used as a parenteral nutrition method.

[38], [39]

Storage conditions

Pantose should be kept in a dark and dry place, closed from children. The temperature is between 15-25 ° C.

[40], [41], [42], [43], [44],

Shelf life

Pantose can be used for 3 years after the release of the drug powder. A fully ready-to-use solution can be kept at 25 ° C for no more than 12 hours.

[45], [46], [47], [48]