The main pharmacokinetic properties of clavuline acid and amoxicillin are quite similar. Both these substances are well absorbed when taken orally, and food intake does not affect the degree of absorption. The peak plasma level is observed about 1 hour after drug use.
These substances have a good distribution volume inside tissues and liquids (in the middle ear with the lungs, peritoneal, as well as pleural fluids, ovaries with the uterus, etc.). Amoxicillin is able to pass into synovia, liver, prostate, muscle tissue, palatine tonsils, discharge of bronchi and appendages of nasal sinuses, as well as gall bladder and saliva.
Amoxicillin with clavulinic acid does not pass through the BBB (if the membranes of the brain are not inflamed), but they are able to pass through the placenta and excrete with the mother's milk.
The active components of the drug are poorly synthesized with a plasma protein. Amoxicillin undergoes a partial metabolic process, but the metabolism of clavulic acid is likely to be more intense.
The half-life of active substances is 1-1.5 hours. This indicator is increased in people with kidney failure in severe form - in amoxyllicin it is 7.5 hours, and for clavulic acid 4.5 hours.
Excretion of amoxicillin is carried out in the kidneys - by filtering the glomeruli and tubular secretions. The substance is almost unchanged. Excretion of clavulic acid is carried out through glomerular filtration, and the substance is partially excreted as disintegration products. Small parts of substances can be excreted through the lungs or the intestines.
Both substances can be withdrawn by hemodialysis. With peritoneal dialysis, only a small amount of the drug can be excreted.