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Panangin
Last reviewed: 03.07.2025
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Indications Panangin
Among the indications:
- cardiac arrhythmias, which occur mainly as a result of disturbances in the electrolyte balance (ion composition) – primarily this concerns hypokalemia (that is, a decrease in the concentration of potassium in the blood);
- cardiac arrhythmia caused by intoxication with digitalis-based drugs, and also due to paroxysms of atrial fibrillation (atrial arrhythmia) or recently developed ventricular extrasystole (ventricular arrhythmia);
- as a treatment for coronary insufficiency (an imbalance between the heart's need to saturate itself with oxygen and its actual delivery).
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Pharmacodynamics
The most important cations found inside cells (K+ and Mg2+) are the main participants in the functioning of various enzymes, and in addition, they help form bonds between different macromolecules, as well as structures inside cells, and contribute to the process of muscle contractility.
The ratio of Ca, calcium ions, Mg and Na outside and inside the cells affects the contractile function of the myocardium. Aspartate, which has an external origin, is an ion mediator. It has significant cellular affinity, and in addition, weak salt dissociation, due to which it allows ions in the form of complex structures to pass into the cells. Potassium and magnesium aspartates contribute to the improvement of metabolic processes in the myocardium.
Pharmacokinetics
The drug is absorbed fairly quickly. Excretion occurs through the kidneys.
Dosing and administration
The medicine is taken orally after meals (because its properties are weakened in the acidic environment of the stomach). Before starting treatment, a consultation with a doctor is required.
The dosage is usually 1-2 tablets three times a day. The maximum allowed per day is 9 tablets (3 pieces three times a day).
The duration of therapy, as well as the need for a repeat course, can only be determined by a doctor.
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Use Panangin during pregnancy
During pregnancy, the drug should be prescribed with great caution (especially during the 1st trimester).
Contraindications
Among the contraindications:
- individual intolerance to any component included in the drug;
- renal failure in acute or chronic form;
- hyperkalemia or hypermagnesemia;
- hypocorticism;
- atrioventricular block 1-3 degrees;
- state of cardiogenic shock (blood pressure is <90 mm);
- amino acid metabolism disorder;
- severe myasthenia;
- erythrocytolysis;
- acute form of non-respiratory acidosis;
- dehydration of the body.
Side effects Panangin
The following side effects may occur when taking the medication:
- vomiting with nausea and diarrhea;
- burning or discomfort in the pancreas (in patients with cholecystitis or anacid gastritis);
- AV block;
- increase in the number of extrasystoles;
- development of hyperkalemia or hypermagnesemia (in this case, symptoms such as a feeling of thirst, a decrease in blood pressure, suppression of the respiratory process, facial flushing, hyporeflexia, and the appearance of convulsions are observed).
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Overdose
Manifestations of overdose include: conduction disorder (especially if the patient previously had problems with the cardiac conduction system).
To get rid of these symptoms, intravenous administration of CaCl2 solution is used. If necessary, hemodialysis is performed, as well as peritoneal dialysis.
Interactions with other drugs
When combined with potassium-sparing diuretics (such as triamterene and spironolactone), heparin and cyclosporine, as well as with β-blockers, ACE inhibitors and NSAIDs, the risk of developing hyperkalemia increases, which can lead to asystole or arrhythmia.
Potassium drugs in combination with GCS help eliminate hypokalemia, which is provoked by the latter. The effect of potassium weakens the side effects that occur when using cardiac glycosides. In combination with Panangin, the negative bathmotropic properties of antiarrhythmic drugs are enhanced.
Painkillers increase the suppressive effect of magnesium on the central nervous system. When combined with drugs such as atracuronium, succinyl chloride, decamethonium, and suxamethonium, the blockade of the neuromuscular system may be enhanced. When combined with calcitriol, the plasma concentration of magnesium increases. The simultaneous use of calcium and magnesium drugs weakens the effectiveness of the latter.
Medicines with enveloping and astringent properties reduce the absorption of Panangin in the gastrointestinal tract, so it is necessary to observe an interval between the use of these drugs - at least 3 hours.
Storage conditions
The medicine should be stored in standard conditions for medicinal products. The storage temperature should be within 15-30°C.
Shelf life
Panangin is permitted to be used for 5 years from the date of manufacture of the drug.
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Attention!
To simplify the perception of information, this instruction for use of the drug "Panangin" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.