Paisin

The medicinal preparation of Paizin is used to treat such a serious disease as tuberculosis. The main active substance is pyrazinamide, an effective anti-tuberculosis drug that is active against persistent tuberculosis bacteria.

Indications Paisin

Paisin is used in the complex therapy of all forms of tuberculosis in conjunction with other anti-tuberculosis drugs.

Release form

Paisin is produced in the form of tablets, flat cylindrical, with a dividing strip on one side.

Pharmacodynamics

The active substance has a good penetrating ability in focal lesions of tuberculosis bacteria. The effectiveness of the drug does not decrease in the acidic environment of necrotic tissues, so the drug is often prescribed for tuberculosis, caseous lymphadenitis, caseous-penevmonic processes. During treatment with the drug Paizin, mycobacterium tuberculosis rapidly develops resistance to it, therefore, almost always, the drug is prescribed together with other drugs of anti-tuberculosis therapy (3-4 drugs are usually used).

Pharmacokinetics

The drug Paizin is absorbed almost without residue in the digestive system. The level of the drug in the blood reaches 45 mcg / ml already two hours after taking 1g. In the body, the drug decomposes into pyrazinic acid, and then into an inactive metabolite. 70% of the main substance (pyrazinamide) is excreted by the kidneys, after a day the drug is completely removed from the body, mainly in the form of metabolites.

Dosing and administration

Payzina is taken orally, preferably after eating. The drug is taken at 20-35 mg per dose, and it is also possible to take a dose three times. On the prescription of the doctor, the drug can be taken once a week for 90 mg, three times a week for 2-2.5 mg or twice a week for 3-3.5 g. The appointment takes into account the weight of the patient (with a weight of more than 50 kg a single dose is 2 mg). The question of prescribing the drug to children under the age of 15 years, is decided by a specialist in each individual case. If the doctor finds the treatment with the help of Paisin expedient, then, as a rule, 0.02-0.03 mg per day is prescribed. In childhood, the daily dose of the drug should not exceed 1.5 mg.

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Use Paisin during pregnancy

Paizin has a high toxic effect on the body, so it is contraindicated during pregnancy and breastfeeding.

Contraindications

Paisin is contraindicated with increased susceptibility to the drug, with liver diseases, gout. Also, the drug is not used to treat patients under the age of 15 years.

Side effects Paisin

The drug Paizin can provoke some disorders in the liver, nausea (vomiting), diarrhea. There may also be a variety of allergic manifestations (rash, itching, etc.), increased uric acid in the blood, in some cases, there is an increased sensitivity of the body to ultraviolet and clinical jaundice.

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Overdose

When an overdose of the drug Paizin noted increased excitability, disruption of the digestive system, liver, increased manifestation of adverse reactions. In case of an overdose, treatment is mostly symptomatic, in particular gastric lavage.

Interactions with other drugs

Simultaneous administration of Paizin and ethionamide increases the likelihood of liver damage, especially in diabetic patients. During the treatment with a combination of these drugs, you must carefully monitor the work of the liver. If any signs of liver failure appear, treatment with these drugs is immediately stopped.

The main substance of the drug (pyrazinamide) lowers the concentration of cyclosporine in the blood, therefore, when treating with cyclosporine, it is necessary to control the level of the drug in the blood from the first days of the administration of Payzin, and after the end of the admission.

Treatment with pyrazinamide and phenytoin simultaneously increases the concentration of the latter in the blood of the patient, which can cause signs of poisoning the body with phenytoin.

Pyrazinamide lowers the therapeutic effect of drugs that are used in the treatment of gout, as well as remedies that help remove uric acid from the body (probenecid, alopurinol, etc.), which can lead to increased levels of uric acid in the blood. In this case, the specialist can adjust the dosage of the drugs.

Zidovudine significantly reduces the level of pyrazinamide in the blood, which increases the likelihood of anemia.

Admission Paisins prevents the conduct of such tests as Ketostix and Acetest, because the sample in this case will be a reddish-brown tint. With simultaneous admission with medications that block tubular secretion, problems can arise with the removal of substances from the body, and a toxic reaction can also become more vivid. Pyrazinamide increases the anti-tuberculosis effect of lemofloxacin and ofloxacin.

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Storage conditions

The drug Paizin must be stored well from the sun's rays, the storage temperature should not exceed 25 ^° C. The drug should be protected from children.

Shelf life

The shelf life of Payzin is five years from the date of manufacture, subject to proper storage conditions. It is not recommended to use the drug after the end of its useful life.