Simultaneous administration of Paizin and ethionamide increases the likelihood of liver damage, especially in diabetic patients. During the treatment with a combination of these drugs, you must carefully monitor the work of the liver. If any signs of liver failure appear, treatment with these drugs is immediately stopped.
The main substance of the drug (pyrazinamide) lowers the concentration of cyclosporine in the blood, therefore, when treating with cyclosporine, it is necessary to control the level of the drug in the blood from the first days of the administration of Payzin, and after the end of the admission.
Treatment with pyrazinamide and phenytoin simultaneously increases the concentration of the latter in the blood of the patient, which can cause signs of poisoning the body with phenytoin.
Pyrazinamide lowers the therapeutic effect of drugs that are used in the treatment of gout, as well as remedies that help remove uric acid from the body (probenecid, alopurinol, etc.), which can lead to increased levels of uric acid in the blood. In this case, the specialist can adjust the dosage of the drugs.
Zidovudine significantly reduces the level of pyrazinamide in the blood, which increases the likelihood of anemia.
Admission Paisins prevents the conduct of such tests as Ketostix and Acetest, because the sample in this case will be a reddish-brown tint. With simultaneous admission with medications that block tubular secretion, problems can arise with the removal of substances from the body, and a toxic reaction can also become more vivid. Pyrazinamide increases the anti-tuberculosis effect of lemofloxacin and ofloxacin.