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Paisin
The medicinal preparation of Paizin is used to treat such a serious disease as tuberculosis. The main active substance is pyrazinamide, an effective anti-tuberculosis drug that is active against persistent tuberculosis bacteria.
Indications Paisin
Paisin is used in the complex therapy of all forms of tuberculosis in conjunction with other anti-tuberculosis drugs.
Pharmacodynamics
The active substance has a good penetrating ability in focal lesions of tuberculosis bacteria. The effectiveness of the drug does not decrease in the acidic environment of necrotic tissues, so the drug is often prescribed for tuberculosis, caseous lymphadenitis, caseous-penevmonic processes. During treatment with the drug Paizin, mycobacterium tuberculosis rapidly develops resistance to it, therefore, almost always, the drug is prescribed together with other drugs of anti-tuberculosis therapy (3-4 drugs are usually used).
Pharmacokinetics
The drug Paizin is absorbed almost without residue in the digestive system. The level of the drug in the blood reaches 45 mcg / ml already two hours after taking 1g. In the body, the drug decomposes into pyrazinic acid, and then into an inactive metabolite. 70% of the main substance (pyrazinamide) is excreted by the kidneys, after a day the drug is completely removed from the body, mainly in the form of metabolites.
Side effects Paisin
The drug Paizin can provoke some disorders in the liver, nausea (vomiting), diarrhea. There may also be a variety of allergic manifestations (rash, itching, etc.), increased uric acid in the blood, in some cases, there is an increased sensitivity of the body to ultraviolet and clinical jaundice.
Dosing and administration
Payzina is taken orally, preferably after eating. The drug is taken at 20-35 mg per dose, and it is also possible to take a dose three times. On the prescription of the doctor, the drug can be taken once a week for 90 mg, three times a week for 2-2.5 mg or twice a week for 3-3.5 g. The appointment takes into account the weight of the patient (with a weight of more than 50 kg a single dose is 2 mg). The question of prescribing the drug to children under the age of 15 years, is decided by a specialist in each individual case. If the doctor finds the treatment with the help of Paisin expedient, then, as a rule, 0.02-0.03 mg per day is prescribed. In childhood, the daily dose of the drug should not exceed 1.5 mg.
Interactions with other drugs
Simultaneous administration of Paizin and ethionamide increases the likelihood of liver damage, especially in diabetic patients. During the treatment with a combination of these drugs, you must carefully monitor the work of the liver. If any signs of liver failure appear, treatment with these drugs is immediately stopped.
The main substance of the drug (pyrazinamide) lowers the concentration of cyclosporine in the blood, therefore, when treating with cyclosporine, it is necessary to control the level of the drug in the blood from the first days of the administration of Payzin, and after the end of the admission.
Treatment with pyrazinamide and phenytoin simultaneously increases the concentration of the latter in the blood of the patient, which can cause signs of poisoning the body with phenytoin.
Pyrazinamide lowers the therapeutic effect of drugs that are used in the treatment of gout, as well as remedies that help remove uric acid from the body (probenecid, alopurinol, etc.), which can lead to increased levels of uric acid in the blood. In this case, the specialist can adjust the dosage of the drugs.
Zidovudine significantly reduces the level of pyrazinamide in the blood, which increases the likelihood of anemia.
Admission Paisins prevents the conduct of such tests as Ketostix and Acetest, because the sample in this case will be a reddish-brown tint. With simultaneous admission with medications that block tubular secretion, problems can arise with the removal of substances from the body, and a toxic reaction can also become more vivid. Pyrazinamide increases the anti-tuberculosis effect of lemofloxacin and ofloxacin.
Medical expert editor
Portnov Alexey Alexandrovich
Education: Kiev National Medical University. A.A. Bogomolets, Specialty - "General Medicine"
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The latest research relating Paisin
WHO is concerned that the actions taken to eliminate the tuberculosis epidemic are not as effective as they should have been. According to new data, governments should improve preventive measures, methods of detection and treatment of the disease.
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Attention!
To simplify the perception of information, this instruction for use of the drug "Paisin" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.