Paisina

The drug Paizina is used to treat such a serious disease as tuberculosis. The main active ingredient is pyrazinamide, an effective anti-tuberculosis drug that is active against resistant tuberculosis bacteria.

Indications Paisina

Paizina is used in complex therapy of all forms of tuberculosis together with other anti-tuberculosis drugs.

Release form

Paizina is available as a tablet, flat cylindrical in shape, with a dividing line on one side.

Pharmacodynamics

The active substance has good penetrating ability into focal lesions of tuberculosis bacteria. The effectiveness of the drug does not decrease in the acidic environment of necrotic tissue, so the drug is often prescribed for tuberculoma, caseous lymphadenitis, caseous-peneumonic processes. During treatment with only Payzin, mycobacterium tuberculosis quickly develops resistance to it, so, almost always, the drug is prescribed together with other drugs for anti-tuberculosis therapy (usually 3-4 drugs are used).

Pharmacokinetics

The drug Payzina is absorbed in the digestive system almost completely. The drug level in the blood reaches 45 mcg/ml already two hours after taking 1g. In the body, the drug decomposes into pyrazinoic acid, and then into an inactive metabolite. 70% of the main substance (pyrazinamide) is excreted by the kidneys, after 24 hours the drug is completely excreted from the body, mainly in the form of metabolites.

Dosing and administration

Payzina is taken orally, preferably after meals. The drug is taken at 20-35 mg per dose, it is also allowed to take the dose in three doses. As prescribed by a doctor, the drug can be taken once a week at 90 mg, three times a week at 2-2.5 mg or twice a week at 3-3.5 g. When prescribing, the patient's weight is taken into account (for weight over 50 kg, a single dose is 2 mg). The question of prescribing the drug to children under 15 years of age is decided by a specialist in each individual case. If the doctor considers treatment with Payzina appropriate, then, as a rule, 0.02 - 0.03 mg per day is prescribed. In childhood, the daily dose of the drug should not exceed 1.5 mg.

[ 2 ]

Use Paisina during pregnancy

Paizina has a high toxic effect on the body, so its use during pregnancy and breastfeeding is contraindicated.

Contraindications

Paizina is contraindicated in case of hypersensitivity to the drug, liver diseases, gout. Also, the drug is not used to treat patients under 15 years of age.

Side effects Paisina

The drug Payzina can provoke some disorders in the liver, nausea (vomiting), diarrhea. Various allergic manifestations (rash, itching, etc.) may also appear, the content of uric acid in the blood may increase, in some cases, increased sensitivity of the body to ultraviolet radiation and clinical jaundice are noted.

[ 1 ]

Overdose

In case of overdose of the drug Paizina, increased excitability, disruption of the digestive organs, liver, increased manifestation of side effects are observed. In case of overdose, treatment is mostly symptomatic, in particular gastric lavage.

Interactions with other drugs

Concomitant use of Paizin and ethionamide increases the risk of liver damage, especially in patients with diabetes. During treatment with a combination of these drugs, liver function must be closely monitored. If any signs of liver failure are detected, treatment with these drugs should be stopped immediately.

The main substance of the drug (pyrazinamide) reduces the concentration of cyclosporine in the blood, therefore, when treating with cyclosporine, it is necessary to monitor the level of the drug in the blood from the first days of taking Paizin, as well as after the end of the course.

Treatment with pyrazinamide and phenytoin simultaneously increases the concentration of the latter in the patient's blood, which may result in signs of phenytoin poisoning.

Pyrazinamide reduces the therapeutic effect of drugs used to treat gout, as well as drugs that help remove uric acid from the body (probenecid, allopurinol, etc.), which can lead to increased uric acid levels in the blood. In this case, a specialist can adjust the dosage of drugs.

Zidovudine significantly reduces the level of pyrazinamide in the blood, which increases the likelihood of developing anemia.

Taking Payzina interferes with such tests as Ketostix and Acetest, since the sample in this case will be red-brown. When taken simultaneously with drugs that block tubular secretion, problems with the elimination of substances from the body may arise, and a toxic reaction may also manifest itself more clearly. Pyrazinamide increases the anti-tuberculosis effect of lemofloxacin and ofloxacin.

[ 3 ], [ 4 ], [ 5 ]

Storage conditions

The drug Paizina should be stored in a place well away from sunlight, the storage temperature should not exceed 25 ⁰ C. The drug should be kept out of reach of children.

Shelf life

The shelf life of Paizin is five years from the date of manufacture, subject to proper storage conditions. It is not recommended to use the drug after its expiration date.