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Pyremol
Last reviewed: 03.07.2025
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Pyremol (synonyms: Paracetamol, Panadol, Paramol, Tylenol, Aminodol, Dimindol, Dolanex, Myalgin, Cetadol, etc.) is an analgesic-antipyretic drug, similar to non-steroidal anti-inflammatory drugs.
Indications Pyremol
The analgesic, antipyretic, and minor anti-inflammatory properties of Pyremol make it appropriate to use it to relieve mild to moderate pain of various etiologies, including:
Indications for the use of this drug as an antipyretic are diseases accompanied by febrile conditions.
Release form
The drug is available in film-coated tablets containing 500 mg of the active ingredient (paracetamol).
Pharmacodynamics
Pharmacodynamics Pyremol is based on the action of paracetamol (N-4-hydroxyphenylacetamide), which by blocking the isoform of cyclooxygenase COX-3 synthesized in the central nervous system inhibits the production of the prostaglandin mediator in the brain. As a result, pain is relieved. The antipyretic effect is achieved as a result of the fact that paracetamol reduces the excitability of thermoreceptors that transmit a signal to the hypothalamus heat production center. However, paracetamol has almost no effect on the process of synthesizing inflammation conductors, since its effect on cytokines, endothelial cells and platelet aggregation is neutralized by cellular enzymes that accelerate oxidative reactions in cells.
Pharmacokinetics
The active substance Pyremol has a high absorption rate and is adsorbed in the small intestine, entering the tissues with the bloodstream. About 20% of paracetamol binds to plasma proteins. The drug penetrates the BBB (and gets into breast milk). About 25 minutes after taking a therapeutic dose of Pyremol, its maximum concentration is reached.
The drug is metabolized in the liver, and inactive metabolites are excreted from the body by the kidneys. The half-life is three hours on average. Some of the active substance Pyrenol is metabolized by removing the acetyl group from the molecule, resulting in the formation of an easily oxidized isomer of aminophenol (para-aminophenol), which, at significant doses of the drug, has a toxic effect on the liver.
Dosing and administration
Pyremol tablets are taken orally - after meals, with a sufficient amount of liquid. A single therapeutic dose for adults is 1 tablet (0.5 g), the maximum single dose is 1.5 g, the maximum daily dose is 3 g.
The maximum permissible daily dose for children is: 3-6 years old - 1-2 g (based on 60 mg per 1 kg of the child's body weight), three times a day; 9-12 years old - 2 g (in 3-4 doses).
Use Pyremol during pregnancy
The use and administration of Pyremol during pregnancy and breastfeeding requires caution.
Contraindications
Contraindications to the use of Pyremol are: hypersensitivity to paracetamol, liver and kidney failure, children under three years of age.
Side effects Pyremol
Possible side effects of the drug include: allergic reactions (skin rash, itching, angioedema); nausea; pain in the stomach; decreased heart rate; renal colic; increased blood pressure associated with damage to the glomeruli of the kidneys (glomerulonephritis); the presence of pus in the urine in the absence of pathogenic microflora.
Negative effects on hematopoiesis may include anemia, decreased platelet count in the blood (thrombocytopenia), decreased granulocyte count in the blood (agranulocytosis), decreased white blood cell count (leukopenia), and increased methemoglobin in the blood (methemoglobinemia). A significant amount of methemoglobin (which cannot carry oxygen from the lungs to the tissues) leads to cyanosis and oxygen starvation.
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Overdose
Overdose of Pyremol (paracetamol) leads to toxic effects on the liver and is manifested by symptoms such as dizziness, nausea, vomiting, pale skin and mucous membranes. These symptoms require immediate hospitalization. As an antidote for overdose of paracetamol, the antitoxic agent acetylcysteine is used (intravenous injections or oral administration).
Interactions with other drugs
The interactions of this drug with other pharmacological drugs are as follows:
- paracetamol enhances the effect of vitamin K antagonists that increase blood clotting (indirect coagulants),
- paracetamol enhances the effect of salicylic acid, caffeine, codeine and antispasmodic drugs;
- Sleeping pills (barbiturates) and antiepileptic drugs reduce the antipyretic effect of paracetamol and increase its toxic effect on the liver.
Storage conditions
Pyrenol should be stored at a temperature not exceeding +25°C, out of the reach of children.
Shelf life
The shelf life is 2 years from the date of manufacture.
Attention!
To simplify the perception of information, this instruction for use of the drug "Pyremol" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.