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Preparations
Padeviks
It is recommended to take padeviks for treatment of colds or flu. The drug has two active substances: dextromethorphan and paracetamol.
Paracetamol - has an analgesic effect, reduces temperature, facilitates the state of fever, has a slight anti-inflammatory effect. Dextromethorphan is an antitussive.
Pharmacodynamics
Padeviks is a combined remedy that effectively helps to cope with cold symptoms. One of the main components of the drug, paracetamol reduces temperature, eliminates fever, well helps to cope with pain in muscles, joints, headache, which often appear in the flu. Dextromethorphan helps to cope with a dry cough by suppressing the corresponding centers in the brain, and it also helps to reduce the excitability of the cough center.
Pharmacokinetics
Paracetamol, which is one of the main active ingredients of Padeviks, is well absorbed into the digestive tract. After taking the drug, after 15 - 50 minutes the maximum concentration is observed in the blood. The distribution of the agent through the tissues proceeds uniformly, binding to plasma proteins is weak. Paracetamol is excreted by the kidneys, the half-life of substances in the body is observed from one to three hours. Completely the drug is excreted from the body every other day.
Dextromethorphan is the second active substance, it is also well absorbed in the digestive system, unchanged and the form of metabolites is excreted by the kidneys.
Use Padeviks during pregnancy
Padeviks are not used during pregnancy, especially in the first trimester, and the drug is contraindicated during breastfeeding. In the second and third trimester, the drug is used with caution, only by the appointment of a specialist, when the expected therapeutic effect exceeds the possible risks to the fetus.
Contraindications
Padeviks are not used for increased susceptibility of some components of the drug, with severe forms of renal and hepatic insufficiency, bronchial asthma, blood diseases, respiratory depression, certain forms of bronchitis (obstructive, chronic, etc.), pneumonia, epilepsy, at the age of 16 years.
The drug is cautiously prescribed for cough with an abundance of sputum, some congenital hyperbilirubinemia, simultaneous administration of monoamine oxidase inhibitors.
Side effects Padeviks
Admission Padeviks can provoke a strong feeling of fatigue, dizziness, a feeling of nausea or vomiting. All these sensations immediately after stopping the drug take place.
In some cases, drug dependence, redness of the skin can develop (extremely rarely allergic reactions occur). Also, after taking the drug, it is possible to disrupt the function of hematopoiesis (leukopenia, thrombocytopenia, etc.).
In patients with a predisposition to bronchospasm, reactions of hypersensitivity to the drug (dyspnea, sweating, angioedema, lowering of blood pressure, shock) are possible.
Dosing and administration
Padeviks is intended for internal reception. The drug is taken once a day for 30 ml, preferably taken before bedtime. If renal or hepatic insufficiency exists, the recommended dose should be reduced. The course of treatment with Padevics is 3 to 4 days, it is not recommended to exceed the duration of treatment without the recommendation of a specialist.
Overdose
Padeviks in case of overdose causes an increased sense of excitement, dizziness, lower blood pressure, palpitations, increased muscle tone, respiratory depression, impaired coordination of arbitrary muscles.
Elevated doses of paracetamol cause intoxication of the body. Lethalization of liver cells leads to a disruption of its functions, incl. Coma (even a lethal outcome is possible). There is also a risk of necrosis of the renal tubules, which can lead to death of the patient. Symptoms of an overdose on the first day are manifested by a feeling of nausea, severe sweating, a general malaise. The next day there is some improvement in health, a slight pain in the abdomen. The liver increases in size, the activity of bilirubin increases, the daily amount of urine decreases. On the third day, jaundice of the skin appears, the function of blood coagulability is disrupted, blood sugar is reduced, and a hepatic coma sets in.
In case of drug overdosage, gastric lavage is necessary in the first six hours, then symptomatic treatment, introduction of SH-group donors, dialysis (removal of the end products of metabolism and excess fluid from the body) is required.
Interactions with other drugs
Padeviks, when taken concomitantly with monoamine oxidase inhibitors and other drugs that depress the central nervous system, increases their toxicity and therapeutic effect.
Drugs that stimulate microsomal oxidation in the liver (rifampicin, ethanol, classical antidepressants, etc.) can lead to severe intoxication even with a slight overdose of paracetamol.
Paracetamol together with zidovudine increases the likelihood of developing neutropenia (a disease in which the number of cells that destroy foreign bacteria in the body is reduced in the blood).
Myelotoxic drugs increase the likelihood of impaired hematopoiesis.
When taking anticoagulants, strict medical supervision is necessary.
The excretion of chloramphenicol slows down when taken with paracetamol.