Ozol

Ozol belongs to the pharmacological group of antiulcer drugs-proton pump inhibitors used in acid-dependent diseases of the gastrointestinal tract. Other trade names of the drug are: Omeprazole, Omeprol, Omega, Omizak, Losek, Gasek, Ultop and others.

[1]

Indications Ozol

Ozole is used in complex therapy:

• peptic ulcer of the stomach and duodenum (including to prevent relapses);
• peptic ulcers of the digestive system;
• gastroesophageal reflux disease;
• ulcerogenic pancreatic adenoma (Zollinger-Ellison syndrome);
• other disorders of digestion (including iatrogenic gastropathies), taking place against a background of gastric hypersecretion.

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Release form

Form release: lyophilized powder for the preparation of solution for injection, in vials of 40 mg.

[3]

Pharmacodynamics

Pharmacodynamics Ozol is provided by the active substance - omeprazole (a benzimidazole derivative), which upon entering the acidic environment of the stomach turns into active metabolites - cyclic sulfenamides.

Accumulating in the secretory tubules of the lining of the gastric mucosa, the active substances (sulfonomeprazole) bind to the cell membrane protein H + / K + -ATPase (hydrogen-potassium adenosine triphosphatase or proton pump) and completely block the work of this enzyme. As a result, the transmembrane transfer (pumping) of sodium (Na +) and potassium (K +) protons ceases in the cells and the normal functioning of the cells that are synthesized by HCl is disrupted.

And thus the process of both spontaneous and stimulated production of hydrochloric acid by parietal cells of the stomach is reversibly reversed.

[4], [5], [6], [7], [8]

Pharmacokinetics

After entering the body, Ozol is absorbed into the small intestine and enters the bloodstream; the maximum content of the drug in blood plasma is observed on average in 0,5-3 hours; systemic bioavailability with intravenous administration is at 98%.

The degree of connection with plasma proteins reaches 90%, part of the drug penetrates through the hematoplacental barrier.

Metabolism Ozole occurs in the liver; 80% of metabolites is excreted from the body by the kidneys - with urine, the rest - by the intestine with excrement. Half-life is about 45-50 minutes. The drug does not accumulate in the body.

[9], [10], [11], [12], [13], [14]

Dosing and administration

The lyophilized powder should be mixed with the diluent applied to the preparation (10 ml); the resulting solution is administered intravenously (slowly). The maximum storage term for the prepared solution is 4 hours.

Dose and duration of therapy are assigned individually, depending on the diagnosis. The standard dosage for exacerbation of peptic ulcer of the stomach and duodenum (in cases of difficulties with taking generic drugs in tablet form) is 40 mg once a day; with gastroesophageal reflux disease - 40 g (once); with Zollinger-Ellison syndrome - 60 mg per day.

[22], [23], [24], [25], [26]

Use Ozol during pregnancy

Use of Ozol during pregnancy is contraindicated.

Contraindications

Contraindications for this drug are hypersensitivity to the drug, oncological diseases of the gastrointestinal tract, lactation period, children's age.

[15], [16], [17], [18]

Side effects Ozol

Possible side effects of Ozol are expressed in headache, pain in the abdomen, joints or muscles; dry mouth and taste disorders; diarrhea or constipation, sleep disorders.

There may also be local swelling, urticaria, flushing and itching of the skin; increased sweating and fever; deterioration of vision; a decrease in the level of leukocytes and platelets in the blood; kidney inflammation.

[19], [20], [21]

Overdose

Ozol overdose is possible if the dosage of the drug is violated and is expressed in a visa of symptoms such as headache, dry mouth, increased heart rate, abdominal pain, convulsions, hypothermia, dyspnea.

[27], [28]

Interactions with other drugs

The use of Ozol simultaneously with clarithromycin increases the concentration of both drugs in the blood plasma; simultaneously with diazepam, warfarin or phenytoin - increases the concentration of these drugs and reduces the rate of their elimination.

Also, Ozol is able to impair the absorption of ketoconazole, itraconazole, and iron preparations.

[29], [30], [31], [32], [33], [34]

Storage conditions

Storage conditions Ozol: in a place protected from light and moisture, at a temperature of + 15-25 ° C.

Shelf life

Shelf life - 24 months. 

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