Oxampicin

Oxampsin is a combined broad-spectrum antibiotic that is used to treat various types of infectious diseases. The international name of this drug is Ampicillin + Oxacillin - in accordance with its active substances, ampicillin and oxacillin. Oxampsin refers to the pharmacological group of penicillins in combinations and, together with some medicines, has a strong bactericidal effect on the human body. The spectrum of the action of Oxampticin is quite wide, but also the side reactions to the drug may turn out to be diverse.

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Indications Oxampicin

Oxampicin is indicated for the therapy of various bacterial infections, the cause of which was a sensitive pathogen. These are diseases of the human respiratory system: from sinusitis to pneumonia; and otitis media, cystitis, cholecystitis, urethritis, gonorrhea, etc. Treating semisynthetic antibiotic Oxampicin skin diseases: face, impetigo, frequent recurrent dermatosis. It is part of a comprehensive recovery after surgery, including rehabilitation against opportunistic infections resulting from HIV infection. Oxampicin is used to treat postpartum complications: infection of amniotic fluid, infectious complications of the respiratory system of the newborn, for which resuscitative measures are necessary, the risk of aspiration pneumonia of the newborn. Oxampsin is also indicated for certain diseases with a severe clinic: meningitis, sepsis, endocarditis.

Release form

Combined antibiotic Oxampicin is produced in several dosage forms: in capsules, in powder for the preparation of solution for injection, both intramuscular and intravenous, as well as in lyophilate for injections. In one capsule of Oxampicin 125 mg of active antibiotic ampicillin and 125 mg of oxacillin. In the powder for the solution, 333.5 ml of ampicillin sodium salt and 166.5 oxacillic sodium salt. The daily dose of Oxampicin is calculated taking into account the age and weight of the patient, and is divided into several receptions.

Pharmacodynamics

Oxampsin is a combined semi-synthetic antibiotic, the main active ingredients of which are ampicillin sodium and oxacillin sodium salts. Ampicillin is a semi-synthetic penicillin of bactericidal action resistant to an acidic environment. Suppresses the multiplication of gram-negative, as well as gram-positive microorganisms that do not form penicillinase. Oxacillin is a semi-synthetic component that is resistant to gram-positive microorganisms forming penicillylase, as well as gram-negative cokes. Oxacillin is also resistant to acidic conditions. It does not extend to non-fermenting Gram-negative bacteria, as well as Pr.vulgaris, Progeneation rettgeri.

Pharmacokinetics

The maximum dose of Oxampicin in the blood is reached in half an hour - an hour after entering the human body. The antibiotic, injected, is concentrated in the blood for a shorter period of time than the capsules of Oksampicin. And the most effective are intravenous injections, after which the maximum dose of active substances is achieved in half an hour. Both active substances of the drug are absorbed equally well. The antibiotic is excreted by urine through the work of the kidneys, and partially with bile. With the following administration of a polysynthetic antibiotic, Oxampicine is not characterized by cumulation.

Dosing and administration

The daily dose of the drug required for therapy depends on the patient's age, weight, and also on the oxampicin form used. Capsules are indicated for children who have reached the age of 3, while the dosage of the drug per day for babies up to 7 years is 100 mg per kg of body weight. For children from 7 to 14 years - 50 mg per kg of body weight. A single dose of Oksampicin, intended for adults and adolescents over the age of 14 years - from 0.5 to 1 g, and daily - 2-4 g. In severe disease clinic, the dosage can increase several times. The dose of Oxampicin per day is divided into 4-6 receptions or injections, the minimum interval between which is 6-8 hours. The injection solution must be prepared immediately before the injection itself. It is prepared in accordance with the attribution to the drug, depending on its dosage and the nature of the injection. The course of treatment Oxampicin takes from 5-7 days to three weeks, which is determined by the degree of infection in the body, the severity of the disease.

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Use Oxampicin during pregnancy

Oxampicin can be used for pregnant women and nursing mothers. However, the benefit of using this medication should exceed the possibility of risk for a child in a pregnant woman. Even at the smallest concentrations, Oxampicin can be absorbed into breast milk, so in the case of a nursing mother it is worthwhile to raise the issue of the complete or temporary cessation of lactation (depending on the duration of treatment of the nursing mother). With caution you need to take oxampicin to women with sensitivity to penicillin substances, as a possible manifestation of various allergic reactions and complications on their background.

Contraindications

Contraindications to treatment with antibiotic Oxampicin is an increased sensitivity to its constituent components. For example, with poor tolerance of penicillins, allergic reactions may appear in the patient. Contraindicated Oxampsin for people suffering from infectious mononucleosis and lymphocytic leukemia. With caution, it is worth taking medicine for patients with bronchial asthma and hay fever, as well as various types of allergies. Patients with such problems Oksampicin treatment is carried out together with the reception of desensitizing agents. During the entire period of antibiotic treatment it is necessary to systematically monitor the functioning of the patient's kidneys, as well as his blood test.

Side effects Oxampicin

During treatment with Oksampitsinom possible occurrence of various allergies: from the skin - hives, swelling, rashes; from the respiratory system - rhinitis, as well as angioedema. There may be conjunctivitis, nausea and vomiting, fever, changes in taste, dysbiosis. In some cases, an anaphylactic shock may occur, at the first sign of which urgent measures must be taken to remove the patient from this condition. When Oxampicin is injected into the body in the form of injections, pain can be felt on the site of the injections, as well as swelling, phlebitis, periphlebitis, and infiltration.

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Overdose

During an overdose of Oxampicin, the possible occurrence or increased side effects of the drug: allergies, intolerance on the part of the digestive system, as well as the development of anaphylactic shock. In case of an antibiotic overdose, it should be stopped immediately, and consult a doctor so that he can take the necessary measures to eliminate the negative consequences. The nature of reactions from overdose determines and symptomatic treatment. If an anaphylactic shock occurs, immediate measures should be taken to bring the patient to a normal state.

Interactions with other drugs

Oxampicin should be taken together with any medication with a doctor, since some of them, such as ascorbic acid, increase absorption, while others - laxatives, glucosamines - lower it. Oxampicin inhibits the synthesis of vitamin K, and also has a negative effect on the microflora of the intestine, so its use should be combined with drugs to restore microflora. Women who use oral contraceptives need to be especially careful, as the action of Oxampicin reduces their effectiveness. The antibiotic enhances the effect on the body of oral anticoagulants, and its combination with probenecid increases the toxic effect of oxampicin on the human body.

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Storage conditions

Combined semisynthetic drug Oxampicin must be stored in a place covered both from exposure to direct sunlight and bright light, and from moisture. Optimal temperature index for storage of Oxampicin does not rise above the 25 degree mark. Well, and, of course, for curious children's eyes and hands, the medicine package must be out of reach and visibility, as, indeed, all the medicinal substances in the house.

Special instructions

With caution should take Oksampitsin people suffering from allergic reactions of different types, because the drug can trigger allergies. To minimize the effect of the antibiotic on the intestinal microflora, Oxampicin treatment must be combined with good antibacterial therapy. The toxic effect of the drug on the central nervous system may occur in the treatment of large doses of patients suffering from kidney failure. Particular attention should also be paid to the reactions of Oxampicin for the treatment of newborns whose mothers have hypersensitivity to penicillins. During the passage of therapy, it is necessary to monitor the general state of the body, in particular the functioning of the kidneys and liver, changes in the blood of the patient.

Shelf life

Semisynthetic antibiotic Oxampicin retains its medicinal properties for 2 years, it is this period that is the period of storage of capsules, powder or lyophilate in dry form. With all the conditions of storage of the drug, it retains its medicinal properties until the end of the period of use. However, it is worth remembering that the shelf life of the prepared injection solution is not extended. The diluted solution for injection should be used immediately after preparation.