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Orgalutran
Last reviewed: 04.07.2025
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Orgalutran helps to reduce gonadotropin levels. The drug is used in treatment programs for infertility - to prevent premature increases in lutropin levels during controlled ovulation.
The drug for stimulating the superovulation process should be used for a short time, during the period when the follicles are at the final stage of growth, when there is a possibility of premature release of the said hormone (often this occurs on the 6th day of stimulation). This effect is reversible, the pituitary gland activity is restored after 2 days.
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Pharmacodynamics
Orgalutran is a gonadorelin antagonist that slows the release of gonadotropins through the pituitary gland.
The therapeutic effect develops when blocking the action of the pituitary endings of GnRH. The drug is firmly synthesized with these endings, providing an immediate effect - a significant decrease in the gonadotropin indicator (mainly LH). The intensity of gonadotropin suppression is determined by the dosage.
Pharmacokinetics
After 1-2 hours from the moment of drug administration, the blood Cmax indicator is recorded. The bioavailability level is 91%. With repeated use, the Css values are noted after 2-3 days. There is an inverse relationship between the serum values of the drug and the woman's weight.
Metabolic processes are carried out with the formation of peptide elements. The half-life is approximately 13 hours.
Excretion is carried out by the intestines (by 75%), as well as by the kidneys (by 22%). Due to the accelerated excretion of drugs from the body, gonadotropin levels are restored fairly quickly. Due to this effect of Orgalutran, it is possible to control the activity of the pituitary gland - suppressing and restoring it in time.
Dosing and administration
The medication is used daily – through subcutaneous injections into the thigh area. Injections should be given at the same time, constantly changing the injection area. The medication has a high rate of reversibility of action, which is why the intervals between injections should be a maximum of 30 hours. If used in the morning, the drug should also be administered on the day when hCG is used, and in the case of evening injections, the last injection should be given in the evening, before the day of hCG. If a procedure is missed, a second dose should not be administered.
Control of ovulation activity stimulation should be started with the FSH substance (for example, Puregon) on the 2nd-3rd day of the course, and Orgalutran in a 0.25 mg dose is used on the 6th day of FSH drug administration. In case of an increased reaction to the stimulation process, the drug is administered earlier, and in case of slow follicular growth - later than the 6th day.
It is prohibited to use liquid that is opaque or contains impurities. Before performing the procedure, you need to wash your hands and also treat the injection site with a cotton swab soaked in alcohol.
Use Organutran during pregnancy
It is prohibited to use the drug during pregnancy.
Contraindications
Main contraindications:
- severe intolerance to the components of the drug;
- postmenopause;
- renal failure;
- breastfeeding period.
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Side effects Organutran
General side effects develop only occasionally: headaches, nausea, epidermal rashes, malaise, dyspnea, dizziness, systemic weakness and pain in the abdominal area.
Sometimes OHSS develops, which is characterized by enlarged ovaries, lower abdominal pain, oliguria, diarrhea, breathing problems, and weight gain.
Local symptoms include redness, swelling and itching in the area where the injection was administered.
Storage conditions
Orgalutran must be stored at temperatures no higher than 30°C.
Shelf life
Orgalutran can be used within a 24-month period from the date of manufacture of the therapeutic substance.
Attention!
To simplify the perception of information, this instruction for use of the drug "Orgalutran" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.