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Orgalutran
Last reviewed: 23.04.2024
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Orgalutran helps reduce gonadotropin levels. The drug is used in treatment programs for infertility - to prevent a premature increase in the values of lyutropin during controlled ovulation.
It is necessary to use the medication to stimulate the process of superovulation for a short time, while the follicles are at the final stage of growth, when there is a probability of a premature release of this hormone (this often happens on the 6th day of stimulation). This effect is reversible, recovery of pituitary activity occurs after 2 days.
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Pharmacodynamics
Orgalutran is a gonadorelin antagonist that slows the release of gonadotropins through the pituitary gland.
The therapeutic effect develops when blocking the action of the pituitary endings of GnRH. The drug is strongly synthesized with these endings, providing an immediate effect - there is a significant decrease in the rate of gonadotropins (mainly LH). The intensity of the depression of gonadotropins is determined by the size of the dosage.
Pharmacokinetics
After 1-2 hours after the use of the drug, a blood index Cmax is recorded. The level of bioavailability is 91%. When reusing Css values are noted after 2-3 days. There is an inverse relationship between serum drug values and woman's weight.
Exchange processes are made with the formation of peptide elements. The term half-life is about 13 hours.
Excretion is carried out by the intestines (75%), as well as the kidneys (22%). In connection with the accelerated elimination of drugs from the body, the indicators of gonadotropins are restored fairly quickly. Thanks to this effect of Orgalutran, it is possible to control the activity of the pituitary gland - in time oppressing and restoring it.
Dosing and administration
The drug is used daily - through s / c injections into the thigh area. It is necessary to carry out injections at the same time, while constantly changing the area of the injection. The drug has a high rate of reversibility of exposure, which is why the intervals between the injections should be a maximum of 30 hours. In the case of use in the morning, the drug should be administered on the day when hCG is used, and in the case of evening injections, the last injection is given in the evening, before the day of hCG. When you skip the procedure, you can not enter the 2nd portion.
The control of ovulation stimulation should be started with an FSH substance (for example, purgona) on the 2-3rd day of the course, and Orgalutran in a 0.25 mg dose is used on the 6th day of the FSH administration. In the case of an enhanced response to the stimulation process, the administration of the drug is made earlier, and with slow follicular growth, later than the 6th day.
It is forbidden to use liquid having an opaque shape or containing impurities. Before performing the procedure, you need to wash your hands, and also treat the site of the injection with a cotton swab soaked in alcohol.
Use Orgalutrana during pregnancy
It is forbidden to use the drug during pregnancy.
Contraindications
The main contraindications:
- severe intolerance to the components of drugs;
- postmenopause;
- kidney failure;
- breastfeeding period.
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Side effects Orgalutrana
Common side effects develop only occasionally: headaches, nausea, epidermal eruptions, malaise, dyspnea, dizziness, systemic weakness and pain in the abdominal area.
OHS sometimes develops, with an increase in the size of the ovaries, pain in the lower abdomen, oliguria, diarrhea, breathing problems and weight gain.
Local symptoms include redness, swelling and itching in the area of the injection.
Storage conditions
Organalutran is required to be kept at temperature indices not exceeding the mark of 30 ° C.
Shelf life
Organalutran can be used within a 24-month term from the time the therapeutic substance is produced.
Attention!
To simplify the perception of information, this instruction for use of the drug "Orgalutran" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.